Approach Phytochemistry of Secondary Metabolites of Maytenus Guianensis Klotzsch ex Reissek (Celastraceae)
DOI:
https://doi.org/10.5902/2179460X22021Keywords:
Chichuá. Celastraceae. Triterpenes.Abstract
The Brazilian Amazon rainforest, even for its richness and biological diversity, can offer the oppotunity for innovative and efficient discovery of molecules with potential use in large scale. The interest in secondary metabolites have grown tremendously in recent amazonian essential oils and plant extracts, the Maytenus guianensis is a shrub native to our region, being popularly known as fruit-werewolf. The leaves are used as anti-inflammatory and infections is also indicated in the treatment of arthritis and hemorrhoids. Thus, the present study aimed to identify the classes of secondary metabolites from the ethanol extract of the fruits, leaves and shell of M. guianensis. We carried out the identification of secondary metabolites with plant extract using specific reagents alkaloids, glycosides cardiotonic, coumarins, flavonoids, tannins, saponins and triterpenes, based on coloration and precipitation. It was found that all the studied structures show botanical alkaloids, coumarins, flavonoids and tannins using any specific reagents. However, the absence of a secondary metabolite which can serve as raw material for synthesis of bioactive substances, particularly drugs and are used in many preparations to benefit human health, such as in the production of food and biological activity against microrganisms.Downloads
References
ALHO, C.J.R. Importância da biodiversidade para a saúde humana: uma perspectiva ecológica. Estudos avançados, v.26, n.74, p.156-164, 2012.
ALMEIDA, M.R.; LIMA, J.A.; SANTOS, N.P.; PINTO, A.C. Pereirina: o primeiro alcaloide isolado no Brasil? Revista Brasileira de Farmacognosia, v.19, n.4, p.54-60, 2009.
ANDRADE, S.F.; CARDOSO, L.G.V.; CARVALHO, J.C.T.; BASTOS, J.K. Anti-inflammatory and antinociceptive activities of extract, fractions and populnoic acid from bark wood of Austroplenckia populnea. Journal of Ethnopharmacology, v.109, p.464-471, 2007.
ANDRADE, J.I.A. Atividade antibacteriana dos extratos dos frutos de Coussapoa asperifolia magnifolia (Trécul) contra Aeromonas hydrophila e fracionamento do extrato metanólico. 2009. Dissertação (Mestrado em Biotecnologia) – Universidade Estadual do Amazonas, Manaus.
BOBBIO, F.O.; BOBBIO, P.A. Introdução à Química dos Alimentos. 3ed. São Paulo: Varela, 2003.
BORRÁS, M.R.L. Plantas da Amazônia: medicinais ou mágicas – Plantas comercializadas no Mercado Municipal Adolpho Lisboa. Manaus: Valer, 2003. 322p.
BULL, L.B.; CULVENOR, C.C.; DICK, A.J. The Pyrrolizidine Alkaloids: Their Chemistry, Pathogenicity and Other Biological Properties. Amsterdam: North-Holland, 1968.
CAZAROLLI, L.H.; ZANATTA, L.; ALBERTON, E.H.; FIGUEIREDO, M.S.R.B. Mini-Revisão sobre metabólitos secundários. Medicinal Chemical, v.8, n.1, p.1429, 2008.
CORSINO, J.; CARVALHO, P.R.F.; KATO, M.J.; LATORRE, L.R.; OLIVEIRA, O.M.M.F.; ARAÚJO, A.R.; BOLZANI, V.S.; FRANÇA, S.C.; PEREIRA, A.M.S.; FURLAN, M. Biosynthesis of friedelane and quinonemethide triterpenoids is compartmentalized in Maytenus aquifolium and Salacia campestres. Phytochemistry, v.55, p.741-748, 2000.
COUTINHO, M.R. Extração de tanino em folhas, sementes e frutos verdes de cinamomo (Melia azedarach L.) com diferentes tipos de solventes. 2013. 42f. Trabalho de conclusão de curso de graduação: Tecnologia em Alimentos da Coordenação dos Cursos de Tecnologia e Engenharia de Alimentos, da Universidade Tecnológica Federal do Paraná – UTFPR. 42f.
CUNHA, A.P.; SALGUEIRO, L.; ROQUE, O.R. Metilxantinas. In: CUNHA, A. P. (Org). Farmacognosia e Fitoquímica. 3. ed. Lisboa: Fundação Calouste Gulbenkian, 2010.
DAS, B. K.; SAHU, S.; PRADHAN, J.; MOHAPATRA, B.C.; MISHRA, B.K.; SARANGI, N. Effect of Magnifera indica kernel as a feed additive on immunity and resistance to Aeromonas hydrophila in Labeo rohita fingerlings. Fish & Shellfish Immunology, v.23, p.109-118, 2007.
DUARTE, L.P.; VIEIRA-FILHO, S.A.; SILVA, G.D.F.; SOUSA, J.R.; PINTO, A.S. Anti-trypanosomal activity of pentacyclic triterpenes isolated from Austroplenckia populnea (Celastraceae). Revista do Instituto de Medicina Tropical de São Paulo, v.44, n.1, p.109-112, 2006.
DUKE, J.A.; VÁSQUEZ, R. Amazonian ethnobotanical dictionary. CRC Press, Boca Raton, Florida, USA, 1994. 114p.
FONSECA, A.P.N.D.; SILVA, G.D.F.; CARVALHO, J.J.; SALAZAR, G.D.C.M.; DUARTE, L.P.; SILVA, R.P.; TAGLIATI, C.A.; ZANI, C.L.; NEVES, T.M.A.; PERES, V.; VIEIRA-FILHO, S.A. (2007). Estudo fitoquímico do decocto das folhas de Maytenus truncata Reissek e avaliação das atividades antinociceptiva, antiedematogênica e antiulcerogênica de extratos do decocto. Química Nova, v.30, n.4, p.842-847.
FRACARO, S.N.; DECONTO, I.; NAKASHIMA, T. Potencial de toxicidade reprodutiva do extrato de Tillandsia usneoides Linnaeus, 1762 (barba-de-pau) em coelhas gestantes. Tese (Mestrado em Ciências Veterinárias), Universidade Federal do Paraná. Curitiba, 2004, 60p.
GONÇALVES, A. L.; ALVES-FILHO, A.; MENEZES, H. Estudo comparativo da atividade antimicrobiana de extratos de algumas árvores nativas. Arquivos do Instituto Biológico, v.72, n.3, p.353-358, 2005.
HOSTETTMAN, K.; QUEIROZ, E.F.; VIEIRA, P.C. Princípios ativos de plantas superiores. São Carlos: EdUFSCar. 2003.
HOWES, L.G.; JAMES, M.J.; FLORIN, T.; WALKER, C. Expert Opin. Invest. Drugs v.16, n.1, p.1255, 2007.
HURTADO, F.B. Contribuição ao estudo fitoquímico e biológico da entrecasca da espécie Maytenus guianensis Klotzsch ex Reissek. 2013. 170 f. Doutorado em Biologia Experimental. Universidade Federal de Rondônia, Porto Velho.
MACARI, P.A.T.; PORTELA, C.N.; POHLIT, A.M. Antioxidant, cytotoxic and UVB-absorbing activity of Maytenus guianesis Klotzsch (Celastraceae) bark extracts. Acta Amazônica, v.36, n.4, p.513-518, 2006.
MATOS, F.J. Introdução à fitoquímica experimental. 3.ed. Fortaleza: Edições UFC, 2009. 141p.
MENA-REJÓN, G.J.; PÉREZ-ESPADAS, A.R.; MOO-PUC, R.E.; CEDILLO-RIVERA, R.; BAZZOCCHI, I.L.; JIMÉNEZ-DIAZ, I.A.; QUIJANO, L. Antigiardial activity of triterpenoids from root bark of Hippocratea excelsa. Journal of Natural Products, v.70, p.863-865, 2007.
MICHELIN, D.C.; MORESCHI, P.E.; LIMA, A.C.; NASCIMENTO, G.G.F.; PAGANELLI, M.O.; CHAUD, M.V. Avaliação da atividade antimicrobiana de extratos vegetais. Revista Brasileira de Farmacognosia, v.15, n.4, p.316-320, 2005.
MORITA, H.; HIRASAWA, Y.; MUTO, A.; YOSHIDA, T.; SEKITAB, S.; SHIROTAB, O. Antimitotic quinoid triterpenes from Maytenus chuchuhuasca. Bioorganic Medicinal Chemistry Letters, v.18, p.1050-1052, 2008.
NIJVELDT, R.J.; NOOD, E.; HOORN, D.E.C.; BOELENS, P.G.; NORREN, K.; LEEUWEN, P.A.M. Flavonoids: a review of probable mechanisms of action and potential applications. Am. J. Clin. Nutr., v.74, n.1, p.418, 2001.
NUÑEZ, M.J.; REYES, C.P.; JIMÉNEZ, I.A.; MOUJIR, L.; BAZZOCCHI, I.L. Lupane triterpenoids from Maytenus species. Journal of Natural Products, v.68, n.7, p.1018-1021, 2005.
OLIVEIRA, D.M.; SILVA, G.D.F.; DUARTE, L.P.; VIEIRA, S.A. Chemical constituents isolated from roots of Maytenus acantophylla Reissek, Celastraceae. Biochemical Systemy Ecology, v.34, p.661-665, 2006.
REVILLA, J. Apontamentos para a cosmética Amazônica. SEBRAE-INPA, Manaus, Amazonas, 2002. 445p.
RIBEIRO, C.V.C.; KAPLAN, M.A.C. Tendências evolutivas de famílias produtoras de cumarinas em Angiospermae. Química Nova, v.25, n.4, p.533-538, 2002.
SCHIMIDT, D. Palmeira Juçara: exploração ecológica dos frutos. Agroecologia e Saúde, 2009.
SIMÕES, C.M.O.; SCHENKEL, E.P.; GOSMANN, G.; MELLO, J.C.P.; MENTZ, L.A.; PETROVICK, P.R. Farmacognosia: da Planta ao Medicamento, 5.ed. Editora da UFSC: Santa Catarina, 2004.
TANAKA, J.C.A.; SILVA, C.C.; FILHO, B.P.D.; NAKAMURA, C.V.; CARVALHO, J.E.; FOGLIO, M.A. Constituintes químicos de Luehea divaricata Mart. (Tiliaceae). Química Nova, v.28, n.5, p.834-837, 2005.
TORRES-ROMERO, D.; KING-DIAZ, B.; JIMÉNEZ, I.A.;. LOTINA-HENNSEN, B.; BAZZOCCHI, I.L. Sesquiterpenes from Celastrus vulcanicola as photosynthetic inhibitors. Journal of Natural Products, v.71, p.1331-1335, 2008.
YANG, C. R. et al. Antifungal activity of C-27 steroidal saponins. Antimicrobial agents and chesmotherapy. .50 (5). p. 1710-1714, 2006.
WINK, M. Evolution of secondary metabolites from anecological and molecular phylo genetic perpective. Phytichemistry, v.64, n.1, p.3-19, 2003.
ZILBERG, D.; ABUTBUL, S.; GOLAN-GOLDHIRSH, A.; BARAZANI, O. Use of Rosmarinus officinalis as a treatment against Streptococcus iniae in tilapia (Oreochromis sp.). Aquaculture, v.238, p.97-105, 2004.
Downloads
Published
How to Cite
Issue
Section
License
To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.
Ethical Guidelines for Journal Publication
The Ciência e Natura journal is committed to ensuring ethics in publication and quality of articles.
Conformance to standards of ethical behavior is therefore expected of all parties involved: Authors, Editors, Reviewers, and the Publisher.
In particular,
Authors: Authors should present an objective discussion of the significance of research work as well as sufficient detail and references to permit others to replicate the experiments. Fraudulent or knowingly inaccurate statements constitute unethical behavior and are unacceptable. Review Articles should also be objective, comprehensive, and accurate accounts of the state of the art. The Authors should ensure that their work is entirely original works, and if the work and/or words of others have been used, this has been appropriately acknowledged. Plagiarism in all its forms constitutes unethical publishing behavior and is unacceptable. Submitting the same manuscript to more than one journal concurrently constitutes unethical publishing behavior and is unacceptable. Authors should not submit articles describing essentially the same research to more than one journal. The corresponding Author should ensure that there is a full consensus of all Co-authors in approving the final version of the paper and its submission for publication.
Editors: Editors should evaluate manuscripts exclusively on the basis of their academic merit. An Editor must not use unpublished information in the editor's own research without the express written consent of the Author. Editors should take reasonable responsive measures when ethical complaints have been presented concerning a submitted manuscript or published paper.
Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.
