A review of anatomical, physiological, biological characteristics and uses of Plectranthus neochilus





Extracts, Essential oil, Biological activity


Plectranthus neochilus’ tea is widely used for medicinal purposes like digestive disorders, liver problems, hangover and to a lesser extend, for treating respiratory infections. It is one type of “boldo” used in different corners of the world because it has a year-round growth, easy adaptation and environmental resistance, tolerating intense sun and demanding little manipulation. This review aims to compile the up-to-date information about P. neochilus obtained from scientific databases (ScienceDirect, Springer, Google Scholar and PubMed). The plant was recently identified and differentiated anatomically and microscopically from anothers also called “boldo”. Many compounds were identified in their extracts (aqueous, ethanolic, hexane among others). The most recent studies point out the importance of its essential oil, rich in mono and sesquiterpenes. Some activities presented by these extracts or essencial oil are: antioxidant, insecticidal, antibacterial, antifungal, anticancer and antischistosomal activity. In relation to the non-traditional use of the plant, it is used to promote phytoremediation or to be used in green roof. P. neochilus has versatility use and high valuable biological character therefore, more studies are necessary with more extracts and formulations of their oil in order to verify activities in different experimental models.


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Author Biographies

Bruna Piaia Ramborger, Universidade Federal do Pampa, Uruguaiana, RS

Aluna de doutorado em Bioquímica pelo programa de Pós-Graduação em Bioquímica da UNIPAMPA 

Maria Elisabeth Gomes Paz, Universidade Federal do Pampa, Uruguaiana, RS

Acadêmica do curso de Ciências da Natureza na Universidade Federal do Pampa (UNIPAMPA)

Elton Luiz Gasparoto Denardin, Universidade Federal do Pampa, Uruguaiana, RS

Professor Associado I da Universidade Federal do Pampa (UNIPAMPA)/Campus Uruguaiana e docente permanente do Programa de Pós-Graduação em Bioquímica

Jefferson de Jesus Soares, Universidade Federal do Pampa, Uruguaiana, RS

Técnico de Laboratório/Área: Química da Universidade Federal do Pampa - UNIPAMPA

Rafael Roehrs, Universidade Federal do Pampa, Uruguaiana, RS

Professor no curso de Ciências da Natureza-Licenciatura e no Programa de Pós-Graduação em Bioquímica e no Programa de Pós-Graduação em Educação em Ciências: Química da Vida e Saúde da Universidade Federal do Pampa. 


ABREU DBO, SANTORO FR, DE ALBUQUERQUE UP, LADIO AH, DE MEDEIROS PM. Medicinal plant knowledge in a context of cultural pluralism: A case study in Northeastern Brazil. Journal of Ethnopharmacology. 2015; 175, 124–130. https://doi.org/10.1016/j.jep.2015.09.019.

AGUIAR GP, LIMA KA, SEVERIANO ME, GROPPO M, AMBRÓSIO SR, CREVELIN EJ. Antifungal activity of the essential oils of Plectranthus neochilus (Lamiaceae) and Tagetes erecta (Asteraceae) cultivated in Brazil. Int J Complement Alt Med. 2018; 11, 31‒35. 10.15406/ijcam.2018.11.00343.

ANTINARELLI LMR, PINTO NC, SCIO E, COIMBRA ES. Antileishmanial activity of some Brazilian plants, with particular reference to Casearia sylvestris. An. Acad. Bras. Ciênc. 2015; 87, 733-742. http://dx.doi.org/10.1590/0001-3765201520140288.

ARCANJO DDR, ALBUQUERQUE ACM, MELO-NETO BB, SANTANA LCLR, MEDEIROS MGF, CITÓ AMGL. Bioactivity evaluation against Artemia salina Leach of medicinal plants used in Brazilian Northeastern folk medicine. Braz. J. Biol. 2012; 72, 505-509. http://dx.doi.org/10.1590/S1519-69842012000300013.

ASCENSÃO L, FIGUEIREDO AC, BARROSO JG, PEDRO LG, SCHRIPSEMA J, DEANS SG, SCHEFFER JJC. Plectranthus madagascariensis: morphology of the glandular trichomes, essential oil composition, and its biological activity. J. Plant Sciences. 1998; 159, 31-38. 10.1086/297518.

ASCENSÃO L, MOTA L, CASTRO M. Glandular trichomes on the leaves and flowers of Plectranthus ornatus: morphology, distribution and histochemistry. Ann. Bot. 1999; 84, 437-447. https://doi.org/10.1006/anbo.1999.0937

BALDIN EL, CROTTI AEM, WAKABAYASHI KAL, SILVA JPGF, AGUIAR GP, SOUZA EF, VENEZIANI RCS, GROPPO M. Plant derived essential oils affecting settlement and oviposition of Bemisia tabaci (Genn.) biotype B on tomato. J Pest Sci. 2013; 86, 301–308. https://doi.org/10.1007/s10340-012-0462-x.

BANDEIRA JM, BIANCHI VJ, RUBIN S, PETERS JA, BRAGA EJB. Genetic similarities among four species of the Plectranthus (L'Hér.) genus. Acta Sci. Biol. Sci. 2010; 32, 43-48 10.4025/actascibiolsci.v32i1.880.

BANDEIRA JM, BARBOSA FF, BARBOSA LMP, RODRIGUES ICS, BACARIN MA, PETERS JA, BRAGA EJB. Composição do óleo essencial de quatro espécies do gênero Plectranthus. Revista Brasileira de Plantas Medicinais. 2011; 13, 157-164. http://dx.doi.org/10.1590/S1516-05722011000200006.

BORGES GA, FERREIRA JF, ELIAS ST, GUERRA ENS, SILVEIRA D, SIMEONI LA. Cytotoxic effect of Plectranthus neochilus extracts in head and neck carcinoma cell lines. African Journal of Pharmacy and Pharmacology. 2016; 10, 157-163. 10.5897/AJPP2015.4355.

BRITO E, GOMES E, FALÉ PL, BORGES C, PACHECO R, TEIXEIRA V, MACHUQUEIRO M, ASCENSÃO L, SERRALHEIRO MLM. Bioactivities of decoctions from Plectranthus species related to their traditional use on the treatment of digestive problems and alcohol intoxication. Journal of Ethnopharmacology. 2018; 28, 147-154. https://doi.org/10.1016/j.jep.2018.04.006.

CAIXETA SC, MAGALHÃES LG, DE MELO NI, WAKABAYASHI KA, AGUIAR GDEP, AGUIAR DDEP. Chemical Composition and in vitro Schistosomicidal Activity of the Essential Oil of Plectranthus neochilus Grown in Southeast Brazil. Chemistry & Biodiversity. 2011; 8, 149-157. http://dx.doi.org/10.1590/S0102-695X2013000600004.

CAMPOS NV, AZEVEDO AA, SANT'ANNA-SANTOS BF. Acúmulo e efeitos fitotóxicos do flúor em folhas de boldo-gambá e capim-cidreira utilizadas para chás. Pesquisa Agropecuária Brasileira. 2010; 45, 646-653. https://dx.doi.org/10.1590/S0100-204X2010000700003.

CODD LE. Lamiaceae, in: Leistner, O.A. (Ed.)., Flora of southern Africa. Botanical Research Institute. Pretoria, 1985.; pp 137–172.

COELHO MFB, ARRUDA RDAS, PEREIRA ED, BOMFIM AB, GERMANO EB. Propagation of Plectranthus neochilus. Schlechter. Journal of Global Biosciences. 2014; 3, 494-498, 2014.

CORREA JC, SCHEFFER MC, MING LC. Cultivo agroecológico de plantas medicinais, aromáticas e condimentares. In, Ministério do Desenvolvimento Agrário, Brasília. 2006.

COUTO MEO. Coleção de plantas medicinais, aromáticas e condimentares. In: Embrapa, Documentos. CPACT/Embrapa. Brasília, 2006.

CREVELIN EJ, CAIXETA SC, DIAS HJ, GROPPO M, CUNHA WR, MARTINS CHG, CROTTI AEM. Antimicrobial activity of the essential oil of Plectranthus neochilus against cariogenic bacteria. Evidence-Based Complementary and Alternative Medicine. 2015, 1-6. http://dx.doi.org/10.1155/2015/102317.

CUNNINGHAM SD, BERTI WR. Remediation of contaminated soils with green plants: An overview. In Vitro Cell Dev-Pl. 1993; 29:207–212.

DUARTE MR, LOPES JF. Stem and leaf anatomy of Plectranthus neochilus Schltr., Lamiaceae. Rev. Bras. Farmacogn. 2007; 17, 549-556. http://dx.doi.org/10.1590/S0102-695X2007000400013.

EPA. United States Environmental Protection Agency - USEPA, 2019. Using Green Roofs to Reduce Heat Islands. https://www.epa.gov/heat-islands/using-green-roofs-reduce-heat-islands (accessed 20 June 2019).

FANELA TL, BALDIN EL, PANNUTI LE, CRUZ PL, CROTTI AE, TAKEARA R, KATO MJ. Lethal and inhibitory activities of plant-Derived essential oils against Bemisia tabaci gennadius (Hemiptera: aleyrodidae) biotype B in tomato. Neotrop. Entomol. 2016; 45, 201–210 DOI 10.1007/s13744-015-0356-8.

GUPTA SK, BHATT P, JOSEPH JS, NEGI PS, VARADARAJ MC. Phenolic constituents and biological activities of leaf extracts of traditional medicinal plant Plectranthus amboinicus Benth (Lamiaceae). Tang. 2013; 3, 1-6. http://dx.doi.org/10.5667/tang.2013.0027.

GURGEL AP, DA SILVA JG, GRANGEIRO AR, OLIVEIRA DC, LIMA CM, DA SILVA ACP, OLIVEIRA RAG, SOUZA IA. In vivo study of the antiinflammatory and antitumor activities of leaves from Plectranthus amboinicus (Lour.) Spreng (Lamiaceae). Journal of Ethnopharmacology. 2009; 125, 361-363. http://dx.doi.org/10.1016/j.jep.2009.07.006.

ISLAM E, YANG X, LI T, LIU D, JIN X, MENG F. Effect of Pb toxicity on root morphology, physiology and ultrastructure in the two ecotypes of Elsholtziaargyi. J Hazard Mater1. 2007; 47, 806–816. 10.1016/j.jhazmat.2007.10.121.

KAPEWANGOLO P, MEYER D. Plectranthus barbatus; Antioxidant, and Other Inhibitory Responses Against HIV/AIDS. In: HIV/AIDS Oxidative Stress and Dietary Antioxidants. USA, 2018 pp 149-159. https://doi.org/10.1016/B978-0-12-809853-0.00013-4.

LARA-FERNÁNDEZ L, DE LA GARZA-TOLEDO H, WONG-PAZ JE, BELMARES R, RODRÍGUEZ-HERRERA R, AGUILA CN. Separation conditions and evaluation of antioxidant properties of “boldo” (Peumus boldus) extracts. J. Med. Plants Res. 2013; 15, 911-917. 10.5897/JMPR13.2562.

LAWAL OA, HUTCHINGS AH, OYEDEJI O. Chemical Composition of the Leaf Oil of Plectranthus neochilus Schltr. J .Essent. Oil Res. 2010; 22, 546-547. 10.1080/10412905.2010.9700396.

LIMA NRW, SODRÉ GA, LIMA HRR, MANCEBO SSS, CAMPOS LV, GIBSON A, SOUZA V, COUTO W, GIACOMO L, DI NARCIZO A, LOBÃO AQ, DELOU CMC. The Efficacy of a Practical Activity in the Construction of Knowledge of the Concepts of Species and Phenotypic Plasticity Using the “BoldoMirim” (Plectranthus neochilus Schltr.). Creative Education. 2018; 8, 2036-2048. 10.4236/ce.2017.813138.

LOLIS MIGA, MILANEZE-GUTIERRE MA. Morfo-anatomia das folhas de Vernonia condensata Baker (Asteraceae), o "figatil". Rev Bras Farmacogn. 2003; 13, 68-71. http://dx.doi.org/10.1590/S0102-695X200300030002.

LORENZI, H, MATOS, FJA. Plantas medicinais no Brasil - nativas e exóticas 2.ed. Nova Odessa: Instituto Plantarum. 2002; pp 544.

LUKHOBA CW, SIMMONDS MS, PATON AJ. Plectranthus: A review of ethnobotanical uses. J. Ethnopharmacol. 2006; 103, 1-24. 10.1016/j.jep.2005.09.011.

MEDEIROS CH, RIBEIRO, LV, LÚCIO PDS, SCHIEDECK G. Enraizamento de Plectranthus neochilus em concentrações de húmus líquido. Rev. Cient. Rural. 2016; 18:18-28.

MORAU D, LIBELLE T, GARDE F. Performance evaluation of green roof for thermal protection of buildings in Reunion Island. Energy Procedia. 2012; 14, 1008 – 1016. 10.1016/j.egypro.2011.12.1047.

MOTA MS, BANDEIRA JM, BRAGA EJB, BIANCHI VJ, PETERS JA. In vitro shoot regeneration of “boldo” from leaf explants. Cienc. Rural. 2010; 40. http://dx.doi.org/10.1590/S0103-84782010005000173.

MOTA L, FIGUEIREDO AC, PEDRO LG, BARROSO JG, MIGUEL MG, FALEIRO ML, ASCENSÃO L. Volatile-oils composition, and bioactivity of the essential oils of Plectranthus barbatus, P. neochilus, and P. ornatusgrown in Portugal. Chem. Biodivers. 2014; 11, 719-732. http://dx.doi.org/10.1002/cbdv.201300161.

PEREIRA GC. Estudo de Viabilidade de Fitorremediação de Sulfentrazone (Boral 500) por “Boldo-Gambá” (Plectranthus neochilus) em Meio Aquoso. Dissertation (Master’s degre in Biochemistry). Universidade Federal do Pampa, Uruguaiana; 2018.

PILON-SMITS E. Phytoremediation. Annu Rev Plant Biol. 2005; 56, 15-39. 10.1146/annurev.arplant.56.032604.144214.

POOLEY EA. A field guide to wild flowers of KwaZulu-Natal and the eastern region. Natal Flora Publications Trust, Durban. 1998.

PROCÓPIO SO, PIRES FR, SANTOS JB, SILVA AA. Fitorremediação de solos com resíduos de herbicidas. In EMBRAPA Tabuleiros Costeiros. Aracaju, 2009.

RAMBORGER BP, GOULARTE CAO, RODRIGUES DT, GAYER MC, CARRIÇO MRS, BIANCHINI CM, PUNTEL RL, DENARDIN ELG, ROEHRS R. The phytoremediation potential of Plectranthus neochilus on 2,4-dichlorophenoxyacetic acid and the role of antioxidant capacity in herbicide tolerance. Chemosphere. 2017; 188, 231-240. http://dx.doi.org/10.1016/j.chemosphere.2017.08.164.

RICE LJ, BRITS GJ, POTGIETER CJ, VAN STADEN J. Plectranthus: a plant for the future? South African Journal of Botany. 2011; 77, 947–959. https://doi.org/10.1016/j.sajb.2011.07.001.

RIJO P, MATIAS D, FERNANDES AS, SIMÕES MF, NICOLAI M, REIS CP. Antimicrobial Plant Extracts Encapsulated into Polymeric Beads for Potential Application on the Skin. Polymers. 2014; 6,479-490. 10.3390/polym6020479.

ROSAL LF, PINTO JEBP, BERTOLUCCI SKV, BRANT RS, NOCULAU ES, ALVES BP. Effect of organic fertilizer sources on biomass and essential oil production of Plectranthus neochilus Schlechter. Rev. Ceres (Impr.). 2011; 58, 670-678. http://dx.doi.org/10.1590/S0034-737X2011000500020.

STIRTON CH. Broad-spectrum pollination of Plectranthus neochilus. Bothalia - African Biodiversity and Conservation. 1997; 12, 229-230 10.4102/abc.v12i2.1402.

SWAIN SS, LAPAMUDA S, BARIK DP, CHAND PK. Agrobacterium x plant factors influencing transformation of ‘Joseph’s coat’ (Amaranthus tricolor L.). Scientia Horticulturae. 2010; 125, 461-468. https://doi.org/10.1016/j.scienta.2010.04.034.

TADESSE D, EGUALE T, GIDAY M, MUSSA A. Ovicidal and larvicidal activity of crude extracts of Maesalan ceolata and Plectranthus punctatus against Haemonchus contortus. Journal of Ethnopharmacology. 2009; 122, 240-244. http://dx.doi.org/10.1016/j.jep.2009.01.014.

TEMPONE AG, SARTORELLI P, TEIXEIRA D, PRADO, FO, CALIXTO IARL, LORENZI H, MELHEM MSC. Brazilian flora extracts as source of novel antileishmanial and antifungal compounds. Mem. Inst. Oswaldo Cruz. 2008; 103, 443-449. http://dx.doi.org/10.1590/S0074-02762008000500006.

VAN JAARSVELD, E, THOMAS, V. South African Plectranthus and the art of turning shade to glade. Simon's Town: Fernwood Press, South Africa. 2006.

VIANA AJS. Estudo químico e de atividade biológica de Plectranthus neochilus Schltr. (Lamiaceae). Dissertation (Master’s degre in Organic Chemistry). Universidade Federal dos Vales do Jequitinhonha e Mucuri, Diamantina. 2011.

YORK T, DE WET H, VAN VUUREN SF. Plants used for treating respiratory infections in rural Maputaland, KwaZulu-Natal, South Africa. J Ethnopharmacol. 2011; 135, 696-710. 10.1016/j.jep.2011.03.072.

WALDIA S, JOSHI BC, PATHAK U, JOSHI MC. The genus Plectranthus in India and its chemistry. Chemistry & Biodiversity. 2011; 8, 244-252 10.1002/cbdv.201000048.




How to Cite

Ramborger, B. P., Paz, M. E. G., Denardin, E. L. G., Soares, J. de J., & Roehrs, R. (2020). A review of anatomical, physiological, biological characteristics and uses of Plectranthus neochilus. Ciência E Natura, 42, e12. https://doi.org/10.5902/2179460X40157



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