Antimicrobial and anti-biofilm activities of Alpinia zerumbet (Pers.) B.L. Burtt & R.M. Sm. essential oil against Corynebacterium ulcerans
DOI:
https://doi.org/10.5902/2179460X41095Keywords:
Antioxidant, Filamentation, AutoaggregationAbstract
Cepas multirresistentes de Corynebacterium ulcerans destacam a necessidade de pesquisas em novos medicamentos e o uso farmacológico de óleos essenciais (OE) pode ser uma alternativa terapêutica. Assim, este estudo teve como objetivo avaliar a atividade antibacteriana e o efeito da concentração subinibidora de AZEO na morfologia bacteriana e na formação de biofilme na superfície do poliestireno por C. ulcerans utilizados em cães. O AZEO foi usado por destilação a vapor das folhas da planta. Os testes de inibição de fosfomolibdênio e hemólise foram realizados para analisar, respectivamente, uma atividade antioxidante e toxicidade. Foram selecionados como inibidores e bactericidas mínimos (MIC e MBC) do AZEO emC. ulcerans e a partir desses resultados foram testados subinibidos dos testes do AZEO. A inatividade do complexo fosfomolibdênio pelo AZEO foi menor que 1% e a capacidade hemolítica foi baixa. Os resultados do estudo antimicrobiano mostram que o AZEO inibiu o crescimento de fundos como cepas microbianas testadas. Os filamentos bacterianos foram observados na presença do AZEO , bem como uma bactéria de controle automático. Houve diferença significativa na inibição do biofilme. Sugerimos que A. zerumbet pode usar uma terapia alternativa para controlar infecções bacterianas induzidas por C. ulcerans .
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