EFEITOS ANTINOCICEPTIVO E ANTI-INFLAMATÓRIO DO EXTRATO DAS FOLHAS DE PIPTADENIA GONOACANTHA (MART.) MACBR. EM MODELOS EXPERIMENTAIS ANIMAIS
DOI:
https://doi.org/10.5902/2179460X13555Keywords:
Analgésico, plantas medicinais, inflamação.Abstract
http://dx.doi.org/10.5902/2179460X13555
Este estudo teve como objetivo avaliar os efeitos anti-inflamatórios e antinociceptivos do extrato das folhas de P. gonoacantha (EPG). O efeito tóxico de EPG foi testado contra A. salina, a fim de determinar a dosagem segura para os ensaios subsequentes. A antinocicepção em ratos Wistar foi avaliada utilizando o modelo de contorções abdominais induzidas por ácido acético e testes em placa aquecida. O efeito anti-inflamatório de EPG foi avaliada por testes de edema da pata induzido por carragenina em ratos. O bioensaio com A. salina mostrou uma baixa toxicidade do EPG (LC50 = 1,508 mg.L-1). A administração oral de EPG (50, 100 e 150 mg.kg-1) reduziu significativamente o número de contorções induzidas por ácido acético, em torno de 61,3%, 71,8% e 64,9%, respectivamente. No entanto, o EPG não prolongou o tempo de latência no teste da placa quente, o que sugere que EPG iniba predominantemente os mecanismos de dor periférica. A administração oral de EPG, em doses de 50 e 100mg.kg-1 inibiu significativamente o edema de pata após 3 h de administração do agente flogístico em 34,5% e 37,5%, respectivamente. Estes dados sugerem que a EPG possui atividade tanto antinociceptiva como anti-inflamatória, podendo estes efeitos ser atribuídos à inibição da COX-2 e libertação de prostaglandinas.
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