Anti-inflammatory and antioxidant potential of silver nanoparticles synthesized using Cinnamomum verum essential oil nanoemulsion
DOI:
https://doi.org/10.5902/2179460X88050Keywords:
Antioxidant, Trans-Cinnamaldehyde, FormulationAbstract
This study evaluated the chemical profile, antioxidant, and anti-inflammatory activity, in an unprecedented way, of silver nanoparticles (AgNPs) synthesized from the essential oil nanoemulsion (NEO) of Cinnamomum verum. For essential oil extraction (EO), the hydrodistillation technique was used, and the chemical constituents were identified by Gas Chromatography Coupled to Mass Spectrometry (GC-MS). The nanoemulsions were prepared using the phase inversion method, and the synthesis of the AgNPs was performed by the Ag reduction method of AgNO3 using NEO. The AgNPs were characterized in terms of chemical profile by UV-Vis Spectrophotometry and particle size by DLS. Antioxidant activity was evaluated using the ABTS radical discoloration method and anti-inflammatory activity by protein denaturation. The majority constituent of the EO was trans-Cinnamaldehyde (82.12%). The maximum SPR band was centered at 420 nm indicanting the characteristic peak of AgNPs. The best IC50 59.46 mg L-1 for antioxidant activity was obtained for AgNP pH 10. The best IC50 for anti-inflammatory activity was 0.3183 mg mL-1. This study brought in an unprecedented way results for AgNPs of C. verum, demonstrating to be efficient in improving the activities tested in this study, and also demonstrating the effect of pH in these formulations.
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