Chemical profile and biotechnological potential larvicidal of a nanoemulsion (o/w) of the essential oil of Salvia officinalis L

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DOI:

https://doi.org/10.5902/2179460X73725

Keywords:

Larvicide, Nanotechnology, Salvia officinalis

Abstract

This study aims to evaluate the chemical profile and biotechnological larvicidal potential of the nanoemulsion of the essential oil of Salvia officinalis L. The leaves of the plant were collected in São Luís, MA, from January to May 2021. The essential oil was extracted by hydrodistillation at 100°C for 3h. Chemical characterization was obtained by GC-MS. The oil-in-water nanoemulsion was formulated by the low-energy phase inversion method and subjected to thermodynamic stability tests. Antioxidant activity is performed by the spectrophotometric method of scavenging hydroxyl radicals from salicylic acid. For larvicidal activity, Aedes aegypti larvae were subjected to EO solutions and nanoemulsions in concentrations (10-100 mg L-1), larval mortality was evaluated, and the LC50 was determined by the Probit method. The majority compounds of the EO were: eucalyptol with 65.14%, camphor (30.63%), and α-Terpineol (1.53%). The formulations were characterized as nanoemulsions with a droplet size <200 nm. The PDI was <0.200, indicating a narrow size distribution. The antioxidant activity exhibited EC50 of 136.29 mg L-1 and 51.59 mg L-1. The nanoemulsion with larvicidal potential showed an LC50 of 71.17 mg L-1. The nanoemulsion showed bioactive potential for larvicidal action, which may be related to the presence of its chemical compounds, and its use is encouraged in the fight against Aedes aegypti.

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Author Biographies

Ana Patrícia Matos Pereira, Universidade Federal do Maranhão

Master's Degree in Health and Environment (PPGSA/UFMA): Biotechnology applied to health; Laboratório de Pesquisa de Pesquisa e Aplicação de Óleos Essenciais (LOEPAV/UFMA); Universidade Federal do Maranhão (UFMA)

Brendha Araújo de Sousa, Universidade Federal do Maranhão

Graduated in Chemistry from Universidade Federal do Maranhão - UFMA (2022). Researcher at the Laboratório de Pesquisa e Aplicação de Óleos Essenciais (LOEPAV/UFMA). Postgraduate in Chemistry Teaching Methodology and Environment and Sustainability from Centro Universitário Leonardo da Vinci - UNIASSELVI (2023).

Thaylanna Pinto de Lima, Universidade Federal de Minas Gerais

Graduating in Industrial Chemistry at Universidade Federal do Maranhão, UFMA, Brasil. Has experience in the field of Chemistry, with an emphasis on Organic Chemistry.

João Pedro Mesquita Oliveira, Universidade Federal do Maranhão

Graduating in Industrial Chemistry at Universidade Federal do Maranhão, UFMA, Brasil.

Cassiano Vasques Frota Guterres, Universidade Federal do Maranhão

Graduating in Chemistry at Universidade Federal do Maranhão, UFMA, Brasil.

Ana Paula Serejo Muniz, Universidade Federal do Maranhão

Degree in Pharmacy- Biochemistry at Universidade Federal do Maranhão (2007). Postgraduate in Clinical Cytology. PhD in Biotechnology (RENORBIO) at Universidade Federal do Maranhão, UFMA, Brasil.

Victor Elias Mouchrek Filho, Universidade Federal do Maranhão

Degree in Industrial Chemistry at Universidade Federal do Maranhão (1994). Master's degree in Chemistry and PhD in Chemistry at Universidade de São Paulo. Professor at the Department of Chemical Technology at UFMA.

Gustavo Oliveira Everton, Universidade Federal do Maranhão

Degree in Chemical Engineering and Master's degree in Health and Environment at Universidade Federal do Maranhão, UFMA. Researcher UFMA. PhD in progress in Chemistry at UFMA - IFMA.

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Published

2024-09-06

How to Cite

Pereira, A. P. M., Sousa, B. A. de, Lima, T. P. de, Oliveira, J. P. M., Guterres, C. V. F., Muniz, A. P. S., Mouchrek Filho, V. E., & Everton, G. O. (2024). Chemical profile and biotechnological potential larvicidal of a nanoemulsion (o/w) of the essential oil of Salvia officinalis L. Ciência E Natura, 46, e73725. https://doi.org/10.5902/2179460X73725

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Vol. 46 (2024): Publicação contínua

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Chemistry

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