INCORPORATION OF CURCUMIN INTO NANOSTRUCTURED SYSTEMS: A REVIEW
DOI:
https://doi.org/10.5902/2179460X19744Keywords:
Curcumin. Nanotechnology. Physicochemical characterization.Abstract
Curcumin is a polyphenolic compound extracted from the rhizome of Curcuma longa Linn with diverse pharmacological properties, such as anti-inflammatory, antioxidant, anticancer, antimicrobial, hepatoprotective, hypoglycemic, among others, being interesting to the development of products containing curcumin, which will bring health benefits. Curcumin can be used as a natural additive to replace the synthetic, as colorants, antioxidants and antimicrobials, and also due to its pharmacological properties. However, their incorporation into functional foods or food supplement is hampered by its low water solubility, susceptibility to alkaline conditions, light, heat and oxidation. Nanotechnology is an emerging field to improve the poor solubility, stability and bioavailability of curcumin. Several types of nanoparticles have been found to be suitable for the encapsulation of curcumin. This article reviews the nanostructured systems containing curcumin, like polymeric nanoparticles, solid lipid nanoparticles, liposome and nanoemulsions. Besides the nanoencapsulation techniques and physicochemical characteristics of these carriers.
Downloads
References
Anandharamakrishnan, C. (2014). Techniques for Nanoencapsulation of Food Ingredients, Springer.
Akbik, D., Ghadiri, M., Chrzanowski, W., Rohanizadeh, R. (2014). Curcumin as a wound healing agent. Life Sciences, 116, 1-7.
Basnet, P., Skalko-Basnet, N. (2011). Curcumin: An Anti-Inflammatory Molecule from a Curry Spice on the Path to Cancer Treatment. Molecules, 16, 4567-4598.
Batista, C. M., Carvalho, C. M. B., Magalhães, N. S. (2007). Lipossomas e suas aplicações terapêuticas: Estado da arte. Revista Brasileira de Ciências Farmacêuticas, 43(2), 167-179.
Bernal, J., Mendiola, J. A., Ibánez, E., Cifuentes, A. (2011). Advanced analysis of nutraceuticals. Journal of Pharmaceutical and Biomedical Analysis 55, 758-774.
Bonifácio, B. V., Silva, P. B., Ramos, M. A. S., Negri, K. M. S., Bauab, T. M., Chorilli, M. (2014). International Journal of Nanomedicine, 9, 1-15.
Bortnowska, G. (2015). Multilayer Oil-in-Water Emulsions: Formation, Characteristics and Application as the Carriers for Lipophilic Bioactive Food Components – a Review. Polish Journal of Food and Nutrition Sciences, 65(3), 157-166.
Calvo, P., Remunan-López, C., Vila-Jato, J. L., Alonso, M. J. (1997). Novel Hydrophilic Chitosan–Polyethylene Oxide Nanoparticles as Protein Carriers. Journal of Applied Polymer Science, 63, 125-132.
Cho, E. J., Holback, H., Liu, K. C., Abouelmagd, S. A., Park, J. Yeo, Y. (2013). Nanoparticle Characterization: State of the Art, Challenges, and Emerging Technologies. Molecular Pharmaceutics, 10, 2093-2110.
Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., Patravale, V. (2010). Curcumin-Loaded Hydrogel Nanoparticles: Application in Anti-Malarial Therapy and Toxicological Evaluation. Journal of Pharmaceutical Sciences, 99(12), 4992-5010.
Ezhilarasi, P. N., Karthik, P., Chhanwal, N., Anandharamakrishnan, C. (2013). Nanoencapsulation Techniques for Food Bioactive Components: A Review. Food and Bioprocess Technology, 6, 628–647.
Ghalandarlaki, N., Alizadeh, A., Ashkani-Esfahani, S. (2014). Nanotechnology-Applied Curcumin for Different Diseases Therapy. BioMed Research International, 2014, 1-23.
Ghosh, S., Banerjee, s., Sil, p. c. (2015). The beneficial role of curcumin on inflammation, diabetes and neurodegenerative disease: A recent update. Food and Chemical Toxicology, 83, 111-124.
Gómez-Estaca, J., Gavara, R., Hernández-Muñoz, P. (2015). Encapsulation of curcumin in electrosprayed gelatin microspheres enhances its bioaccessibility and widens its uses in food applications. Innovative Food Science and Emerging Technologies, 29, 302-307.
Guterres, S. S., Alves, M. P., Pohlmann, A. R. (2007). Polymeric Nanoparticles, Nanospheres and Nanocapsules for Cutaneous Applications. Drug Target Insights, 2, 147-157.
Hong, W., Chen, D. H., Zhao, X. L., Qiao, M. X., Hu, H. Y. (2008). Preparation and study in vitro of long-circulating nanoliposomes of curcumin. Zhongguo Zhong Yao Za Zi, 33(8), 889-892.
Huang, YS., Hsieh, TJ., Lu, CY. (2015). Simple analytical strategy for MALDI-TOF-MS and nanoUPLC–MS/MS: Quantitating curcumin in food condiments and dietary supplements and screening of acrylamide-induced ROS protein indicators reduced by curcumin. Food Chemistry, 174, 571-576.
IM, K., Maliakel, A., Kumar, D., Maliakel, B., Kuttan, R. (2015). Improved blood–brain-barrier permeability and tissue distribution following the oral administration of a food-grade formulation of curcumin with fenugreek fibre. Journal of functional foods, 14, 215-225.
Kakkar, V., Singh, S., Singla, D., Kaur, I. P. (2011). Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Molecular Nutrition & Food Research, 55, 495-503.
Karewicz, A., Bielska, D., Gzyl-Malcher, B., Kepczynski, M., Lach, R., Nowakowska, M. (2011). Interaction of curcumin with lipid monolayers and liposomal bilayers. Colloids and Surfaces B: Biointerfaces, 88, 231- 239.
Li, M., Ma, Y., Cui, J. (2014). Whey-protein-stabilized nanoemulsions as a potential delivery system for water-insoluble curcumin. LWT - Food Science and Technology, 59, 49-58.
Li, Z., Jiang, H., Xu, C., Gu, L. (2015). A review: Using nanoparticles to enhance absorption and bioavailability of phenolic phytochemicals. Food Hydrocolloids, 43, 153-164.
Lin, YL., Liu, YK., Tsai, NM, Hsieh, JH., Chen, CH., Lin, CM., Liao, KW. (2012). A Lipo-PEG-PEI complex for encapsulating curcumin that enhances its antitumor effects on curcumin-sensitive and curcumin-resistance cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 8, 318-327.
Livney, Y. D. (2015) Nanostructured delivery systems in food: latest developments and potential future directions. Current Opinion in Food Science, 3, 125-135.
May, A., Cecílio Filho, A.B., Cavarianni, R.L., Barbosa, J.C. (2005). Desenvolvimento e produtividade da cúrcuma (Curcuma longa L.) em função de doses de nitrogênio e potássio. Revista Brasileira de Plantas Medicinais, 7(3), 72-78.
Mehnert, W., Mader, K. (2001). Solid lipid nanoparticles Production, characterization and applications. Advanced Drug Delivery Reviews, 47, 165-196.
Mohanraj, V. J., Chen, Y. (2006). Nanoparticles – A Review. Tropical Journal of Pharmaceutical Research, 5(1), 561-573.
Noack, A., Hause, G., Mäder, K. (2012). Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles. International Journal of Pharmaceutics, 423, 440- 451.
Pathak, L., Kanwal, A., Agrawal, Y. (2015). Curcumin loaded self assembled lipid-biopolymer nanoparticles for functional food applications. Journal of Food Science and Technology, 52(10), 6143-6156.
Pinheiro, A. C., Coimbra, M. A., Vicente, A. A. (2016). In vitro behaviour of curcumin nanoemulsions stabilized by biopolymer emulsifiers e Effect of interfacial composition. Food Hydrocolloids, 52, 460-467.
Prasad, S., Gupta, S. C., Tyagi, A. K., Aggarwal , B. B. (2014). Curcumin, a component of golden spice: Frombedside to bench and back. Biotechnology Advances, 32, 1053-1064.
Rao, P. J., Khanum, H. (2016). A green chemistry approach for nanoencapsulation of bioactive compound e Curcumin. LWT - Food Science and Technology, 65, 695-702.
Ravichandran, R. (2013). Studies on Dissolution Behaviour of Nanoparticulate Curcumin Formulation. Advances in Nanoparticles, 2, 51-59.
Sari, T. P., Mann, B., Kumar, R., Singh, R. R. B., Sharma, R., Bhardwaj, M., Athira, S. (2015). Preparation and characterization of nanoemulsion encapsulating curcumin. Food Hydrocolloids, 43, 540-546.
Sharma, R. A., Gescher, A. J., Steward, W. P. (2005). Curcumin: The story so far. European Journal of Cancer, 41, 1955-1968.
Silva-Buzanello, R. A., Ferro, A. C., Bona, E., Cardozo-Filho, L., Araújo, P. H. H., Leimann, F. V., Gonçalves, O. H. (2015). Validation of an Ultraviolet–visible (UV–Vis) technique for the quantitative determination of curcumin in poly(L-lactic acid) nanoparticles. Food Chemistry, 172, 99-104.
Sun, M., Su, X., Ding, B., He, X., Liu, X., Yu, A., Lou, H., Zhai, G. (2012). Advances in nanotechnology-based delivery systems for curcumin. Nanomedicine, 7(7), 1085-1100.
Tiyaboonchai, W., Tungpradit, W., Plianbangchang, P. (2007). Formulation and characterization of curcuminoids loaded solid lipid nanoparticles. International Journal of Pharmaceutics, 337, 299-306.
Torres-Escribano, S., Denis, S., Blanquet-Diot, S., Calatayud, M., Barrios, L., Vélez, D., Alric, M., Montoro, R. (2011). Comparison of a static and a dynamic in vitro model to estimate the bioaccessibility of As, Cd, Pb and Hg from food reference materials Fucus sp. (IAEA-140/TM) and Lobster hepatopancreas (TORT-2). Science of the Total Environment, 409, 604-611.
Yallapu, M. M., Gupta, B. K., Jaggi, M., Chauhan, S. C. (2010). Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. Journal of Colloid and Interface Science, 351, 19-29.
Yao, M., McClements, D. J., Xiao, H. (2015). Improving oral bioavailability of nutraceuticals by engineered nanoparticle-based delivery systems. Current Opinion in Food Science, 2, 14-19.
Wang, S., Marcone, M F., Barbut, S., Lim, L. T. (2012). Fortification of dietary biopolymers-based packaging material with bioactive plant extracts. Food Research International, 49, 80-91.
Zlotogorski, A., Dayan, A., Dayan, D., Chaushu, G., Salo, T., Vered, M. (2013). Nutraceuticals as new treatment approaches for oral cancer – I: Curcumin. Oral Oncology, 49, 187-191.
Zou, L., Zheng, B., Liu, W., Liu, C., Xiao, H., McClements, D. J. (2015). Enhancing nutraceutical bioavailability using excipient emulsions: Influence of lipid droplet size on solubility and bioaccessibility of powdered curcumin. Journal of functional foods, 15, 72-83.
Downloads
Published
How to Cite
Issue
Section
License
To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.
Ethical Guidelines for Journal Publication
The Ciência e Natura journal is committed to ensuring ethics in publication and quality of articles.
Conformance to standards of ethical behavior is therefore expected of all parties involved: Authors, Editors, Reviewers, and the Publisher.
In particular,
Authors: Authors should present an objective discussion of the significance of research work as well as sufficient detail and references to permit others to replicate the experiments. Fraudulent or knowingly inaccurate statements constitute unethical behavior and are unacceptable. Review Articles should also be objective, comprehensive, and accurate accounts of the state of the art. The Authors should ensure that their work is entirely original works, and if the work and/or words of others have been used, this has been appropriately acknowledged. Plagiarism in all its forms constitutes unethical publishing behavior and is unacceptable. Submitting the same manuscript to more than one journal concurrently constitutes unethical publishing behavior and is unacceptable. Authors should not submit articles describing essentially the same research to more than one journal. The corresponding Author should ensure that there is a full consensus of all Co-authors in approving the final version of the paper and its submission for publication.
Editors: Editors should evaluate manuscripts exclusively on the basis of their academic merit. An Editor must not use unpublished information in the editor's own research without the express written consent of the Author. Editors should take reasonable responsive measures when ethical complaints have been presented concerning a submitted manuscript or published paper.
Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.
