Circadian rhythm synchronization under the influence of pain: PIM model with memory
DOI:
https://doi.org/10.5902/2179460X89844Keywords:
Circadian rhythms, Synchronization, Couple oscillators, MemoryAbstract
In this work, we propose and analyze the existence of synchronization/dissynchronization states of in-phase and coupled oscillators that model the influence of external factors such as pain on the biological rhythms of sleep-wakefulness and body temperature under the memory effect. We show the well-posedness of the proposed model and derive analytical solutions for the oscillator system in the synchronized state. The theoretical results are accompanied by some numerical simulations that indicate that the existence of memory contributes to the synchronization of the oscillator system.
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Bard, E., Youngmin, P., & Dan, W. (2019). Recent advances in coupled oscillator theory. Recent advances in coupled oscillator theory, 377:1 – 16. DOI: https://doi.org/10.1098/rsta.2019.0092
Bick, C., Goodfellow, G., Laing, C. R., & Martens, E. A. (2019). Understanding the dynamics of biological and neural oscillator networks through mean-field reductions: a review. arXiv, 10(9):1–43. DOI: https://doi.org/10.1186/s13408-020-00086-9
Bumgarner, J. R., Walker, W. H., & Nelson, R. J. (2021). Circadian rhythms and pain. Neuroscience Biobehavioral Reviews, 129:296–306. DOI: https://doi.org/10.1016/j.neubiorev.2021.08.004
Cai, Z., Zheng, Z., & Xu, C. (2022). Exact dynamics of phase transitions in oscillator populations with nonlinear coupling. Communications in Nonlinear Science and Numerical Simulation, 107:106–129. DOI: https://doi.org/10.1016/j.cnsns.2021.106129
Contessa, N. & Cezaro, A. (2017). Derivadas fracion´arias na modelagem do ritmo circadiano. Scientia Plena, 13(4):1–43. DOI: https://doi.org/10.14808/sci.plena.2017.049909
Diethelm, K. (2004). The analysis of fractional differential equations. (Lectutes Notes in Mathematics). Springer.
D¨orfler, F. & Bullo, F. (2014). Synchronization in complex networks of phase oscillators: A survey. Automatica, 50(6):1539–1564. DOI: https://doi.org/10.1016/j.automatica.2014.04.012
Glaeser, S. S., Cezaro, F., & Cezaro, A. (2023a). Analysis of circadian rhythm synchronization under the influence of pain. Ciˆencia e Natura, 45(16):1–14.
Glaeser, S. S., Cezaro, F., & Cezaro, A. (2023b). Synchronization of the circadian rhythms with memory: A simple fractional-order dynamical model based on two coupled oscillators. Trends in Comput. Appl. Mathematics, 1(1):1–15.
Glaeser, S. S., Santos, A. T., Cezaro, A., Machado, C. M. d. S., & Adamatti, D. F. (2018). Modeling of circadian rhythm under influence of pain: an approach based on multi-agent simulation. ADCAIJ: Advances in Distributed Computing and Artificial Intelligence Journal, 7(2):17–25. DOI: https://doi.org/10.14201/ADCAIJ2018721725
Hasting, M., Reddy, A., & Maywood, E. (2003). A clockwork web: circadian timing in brain and periphery, in health and disease. Nature Reviews Neuroscience, 4:649–661. DOI: https://doi.org/10.1038/nrn1177
Klerman, E. B. & Hilaire, M. S. (2007). Review: On mathematical modeling of circadian rhythms, performance, and alertness. Journal of Biological Rhythms, 22(2):91–102. DOI: https://doi.org/10.1177/0748730407299200
Kuramoto, Y. (1984). Chemical Oscillations, Waves, and Turbulence. Berlin: Springer. DOI: https://doi.org/10.1007/978-3-642-69689-3
Moore-Ede, M. C., Czeisler, C. A., & Richardson, G. S. (1983). Circadian timekeeping in health and disease. New England Journal of Medicine, 309(9):530–536. DOI: https://doi.org/10.1056/NEJM198309013090905
Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. (2022). Circadian rhythm and disease: Relationship, new insights, and future perspectives. Journal of Cellular Physiology, 237(8):3239–3256. DOI: https://doi.org/10.1002/jcp.30815
Palada, V., Gilron, I., Canlon, B., Svensson, C. I., & Kalso, E. (2020). The circadian clock at the intercept of sleep and pain. PAIN, 161(5):894–900. DOI: https://doi.org/10.1097/j.pain.0000000000001786
Pikovisky, A., Rosemblum, M., & Kurths, J. (2001). Synchronization: A Universal Concept in Nonlinear Sciences (1th ed). Cambridge University Press. DOI: https://doi.org/10.1017/CBO9780511755743
Rodrigues, F. A., Peron, T. K. D., Ji, P., & Kurths, J. (2016). The kuramoto model in complex networks. Physics Reports, 610:1–98. DOI: https://doi.org/10.1016/j.physrep.2015.10.008
Silverthorn, D. (2018). Human Physiology: An Integrated Approach (1th ed). Pearson.
Strogatz, S. H. (1987). Human sleep and circadian rhythms: a simple model based on two coupled oscillators. J. Math. Biol, 25:327–347. DOI: https://doi.org/10.1007/BF00276440
Strogatz, S. H. (2000). From kuramoto to crawford: exploring the onset of synchronization in populations of coupled oscillators. Physica D, 143:1–20. DOI: https://doi.org/10.1016/S0167-2789(00)00094-4
Tass, P. A. (1999). Phase Resetting in Medicine and Biology: Stochastic Modelling and Data Analysis. New York: Springer. DOI: https://doi.org/10.1007/978-3-540-38161-7
Walker, W., Walton, J., & DeVries, A. (2020). Circadian rhythm disruption and mental health. Transl Psychiatry, 10(28):1–13. DOI: https://doi.org/10.1038/s41398-020-0694-0
Wang, W., Yuan, R., & Mitchell, J. (2022). Desynchronizing the sleep-wake cycle from circadian timing to assess their separate contributions to physiology and behaviour and to estimate intrinsic circadian period. Nature Protocols, 10(28):1–15.
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