An overview of the healing potential of silver nanoparticles in the treatment of diabetic wounds
DOI:
https://doi.org/10.5902/2179460X86600Keywords:
Metallic nanoparticles, Antibacterial, Healing propertiesAbstract
Silver is a metal known for its antimicrobial and antibacterial properties, and when reduced to the nanoparticle scale, there is an increase in its surface area, which enhances these properties. As a result, silver nanoparticles have been widely studied and used in wound treatment, especially in cases of chronic infections and infected wounds, such as those found in people with diabetes. The purpose of this study was to provide an updated overview of the potential of silver nanoparticles and their applications in diabetic wound treatment. A search was conducted in the PubMed Database, ranging over the last five years, using the descriptors and Boolean markers: silver nanoparticles AND wound healing AND diabetes. The search resulted in 54 articles, of which 14 were selected to compose this review according to the proposed criteria. From the studies included in this review, it was possible to observe that among many nanostructures containing AgNPs, hydrogel and spray were the most used for topical application in vivo. Of the analyzed articles, AgNPs showed promising results for the healing of diabetic wounds, showing anti-inflammatory and antibacterial properties
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References
Balcucho, J. et al. (2023). Microbially Synthesized Polymer-Metal Nanoparticles Composites as Promising Wound Dressings to Overcome Methicillin-Resistance Staphylococcus aureus Infections. Polymers (Basel), 15(4).
Burgess, J. L. et al. (2021). Diabetic Wound-Healing Science. Medicina, 57(10).
Chai, C. et al. (2022). Regenerative antibacterial hydrogels from medicinal molecule for diabetic wound repair. Bioactive Materials, 25, 541–554.
Chen, C. Y. et al. (2020). Ångstrom-scale silver particle-embedded carbomer gel promotes wound healing by inhibiting bacterial colonization and inflammation. Science Advances, 6(43).
Fathil, M. A. M. & Katas, H. (2023). Antibacterial, Anti-Biofilm and Pro-Migratory Effects of Double Layered Hydrogels Packaged with Lactoferrin-DsiRNA-Silver Nanoparticles for Chronic Wound Therapy. Pharmaceutics, 15(3).
International Diabetes Federation – Diabetes Atlas. (2022). https://diabetesatlas.org/
Kumar, S. S. D., Houreld, N. N. & Abrahamse, H. (2020). Selective Laser Efficiency of Green-Synthesized Silver Nanoparticles by Aloe arborescens and Its Wound Healing Activities in Normal Wounded and Diabetic Wounded Fibroblast Cells: In vitro
Studies. International Journal of Nanomedicine, 15, 6855-6870.
Liu, M. et al. (2023). Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing. International Journal of Nanomedicine, 18, 1537-1560.
Mei, J. et al. (2022). An injectable photo-cross-linking silk hydrogel system augments diabetic wound healing in orthopaedic surgery through spatiotemporal immunomodulation. Journal of Nanobiotechnology, 20(1), 232.
Nagarjuna, R. V. et al. (2022). Gallocatechin-silver nanoparticles embedded in cotton gauze patches accelerated wound healing in diabetic rats by promoting proliferation and inhibiting apoptosis through the Wnt/β-catenin signaling pathway. PLOS ONE, 17(6).
Pereira, R. A. et al. (2022). The use of textile fibers impregnated with silver nanoparticles against infectious diseases, its health risks and health regulation. Research, Society and Development, 11(6).
Permyakova, E. S. et al. (2022). Ag-Contained Superabsorbent Curdlan–Chitosan Foams for Healing Wounds in a Type-2 Diabetic Mice Model. Pharmaceutics, 14(4), 724.
Ruffo, M. et al. (2022). Synthesis and evaluation of wound healing properties of hydro-diab hydrogel loaded with green-synthetized AGNPS: in vitro and in ex vivo studies. Drug Delivery and Translational Research, 12(8).
Scappaticci, R. A. F. et al. (2021). Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats. Antibiotics, 10(11).
Toczek, J. et al. (2022). Benefit of Silver and Gold Nanoparticles in Wound Healing Process after Endometrial Cancer Protocol. Biomedicines, 10(679).
Younis N. S., Mohamed M. E. & El Semary N. A. (2022). Green Synthesis of Silver Nanoparticles by the Cyanobacteria Synechocystis sp.: Characterization, Antimicrobial and Diabetic Wound-Healing Actions. Mar Drugs, 20(1).
Zeng, Q. et al. (2023). Tailoring Food Biopolymers into Biogels for Regenerative Wound Healing and Versatile Skin Bioelectronics. Nanomicro Lett, 15(1).
Zhang, D. et al. (2022). Effect of Silver Nanoparticles With Thermoplastic Polyurethane on Postoperative Rehabilitation of Diabetic Patients With Open Fracture of Lower Extremities. Front Surg, 9:954155.
Zhang, K. et al. (2021). Therapeutic Effect of Epidermal Growth Factor Combined With Nano Silver Dressing on Diabetic Foot Patients. Frontiers in Pharmacology, 12.
Zhang, R. et al. (2022). Clinical translation of gold nanoparticles. Drug Delivery And Translational Research, 13(2), 378-385.
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