Farmacology study of Heterothalamus brunioides: lethal dosis general activity and effects upon central nervcus system
DOI:
https://doi.org/10.5902/2179460X25467Abstract
Heterothalamus brunioides Less is a native herb in Santaninha da Boa Vista (RS), and it is used in popular medicine to decrease toxilogical effect caused by snake bites. The objective of this study was to evaluate the lethal dosis as well as the effects of the aquous extract of this plant upon the general activity and central nervous system. The lethal dosis on Wistar rats was 143,2 mg/kg of the cold aquous extract and when it was boiled none toxicological effect was observed. So, this substance is thermolabile. Since the general activity was not effects by the use of this drug, there is no non-indication for its recomendation. The effect upon the central nervous system is characterized by depression.
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ARRUDA, E.S. Atividade anti-inflamatória da Juecroton humilis, Fr Diedrichs nativo de Cuiabá. Monografia C. Especialização, CAPES, Cuiabá, M.T. 1985.
CABREIRA, A.J. Compuestos Bonacrenses. Tomo IV Seccion Botânica. La plata, 1941, 1-450 pp.
CARLINI, E.A. Farmacologia Prática sem Aparelhagem. Sanvier Ed. Livros. São Paulo, 1973, 199 pp.
CHAGAS, A.M.; MACHADO, E.K.; CATALDI, F.R.; BOELTER, R. & FRICK, W. - Farmacologia Geral, Edições UFSM. Santa Maria, 1978. 62pp.
CHAGAS, A.M.; SALDANHA, C.M.; CUNHA, C.M.; VIEIRA, H.; SITYÁ,J. & KURTZ, F. Mário. Leucograma, Eritograma, Hemoglobina e tempo de coagulação após o uso oral e intraperitoneal de Heterothalamus brunioides em Ratos Wistar. Ciência e Natul'a Vol.9, 1987.
COIMBRA, C.F. Atividade Farmacologica do "Paratudo" Tabebuia orchracea C. Stanley. Monografia do Curso Nacional de Especialização em Farmacologia dos Produtos Naturais, Cuiabá, MT. 1985.
DIXON, W.J. & MASSEY, F.J. Introdução to Statical Analysis. Mc. Graw-Hill, N.Y. Third. Edition, 1969,638 p.
FRANCESCHENE, G.A. Ações Farmacológicas da "Rawolfia weddelliana" (m. arg). Monografia do Curso Nacional de Especialização em Farmacologia dos Produtos Naturais, Cuiabá, MT. 1985.
HOENE, F. C. Plantas e substâncias vegetais tóxicas e medicinais. Ed. Graphicars. São Paulo, 1939, 268 p.
KRANYZ, J.C. & CARR, C.J. Pharmacological Principles of Medical Practice, The Willians & Willians Company, Baltimore 1961, 1498 p.
NAKAGAWA, M.; NAKANISHI, K. Strutures of cabenegrina A-I and A-lI potente anti-snake venouns. Tetrahedron Letters, Great Britain, 23 (38):3855-8,1974.
OVIEDO, C.A.; FRONCIANI, G.; MORENO, R. & MASS, L.C. Accion hipoglicemiante de la Stevia rebaudiana Bertoni (Kaa-hee). The ent. Congr. Exarpta Med, 209,1970.
VALTTE, G. Precis de Pharmacodynamic Zéme. Ed Masson & cie Edit. Paris, 1964, 187 p.
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