Effect of crude aqueous extract of Polygonum acre H.B.K. on the smooth muscle and their correlation with the chemical composition
DOI:
https://doi.org/10.5902/2179460X25536Abstract
Polygonum acre H.B.K. perennial native plant from humid and swampy places, very abundant in Brazil, is used in popular medicine as antihemorrhagic and as expectorant. The authors objective were to study the 20% crude aqueous extract of the vegetable leaves on smooth muscle using rats uterus in oestrus (stilboestrol) and to verify the correlaction of this effect with the chemical composition. For this purpose, we used rats uterus preparation in Magnus bath with De Jalon's solution aerated. Those concentration were choosen from pilot experiences and were 0,5; 1,0 and 2,0 ml (0,2 g/ml) of the crude aqueous extract of the P. acre H.B.K. and the adrenaline doses were 1,0 µg. The results showed that the contraction of the smooth muscle and the alteration of the frequence produced by the extract were not significant, this plant flavonoids, which could be responsable by the constriction effect on the smooth muscle, perhaps by one direct or indirect action. This suggests that the effect of the crude extract are possibly due to the indirect action.
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CLARK, W.G. and GEISSMAN, T.A. - Potentiation of .effects of epinephrine by flavonoid ("vitamin P-like") compounds. Relation of struture to activity. J. Pharmac. Exp. Ther, 95: 363-381, 1949, in: GOODMANN, L.S.M.A. and GILMAN, A. - As bases farmacológicas da terapêutica. 3a. ed., Ed. Guanabara Koogan, Rio de Janeiro, 1967, 1530 p.
DE JALON, B. - Experiments with other smooth muscle preparations, in: PERRY, .W. L. M. - Pharmacological: Experiments on Isolated Preparations, 2a. ed., E. & S. Livingstone, London, 1970,88-111 p.
DIXON, W.J. and MASSEY Jr., F.S.J. - Introduction to Statistical-Analyses. MacGraw Hill, New York, 1969, 122p.
FETKHULLINA, G.A. and BULENKOV, T. I. - Quantitative determination of flavonoids in the liquid extract of Polygonum hydropiper and Hypericum tincture. Farmatsiya, 33(5):38-40, 1984, in: Biol. Abst. 79(6): 53064, 1984.
FUKUYAMA, Y.; SATO, T.; ASAKAWA, Y. and TAKEMOTO, T. - A potente cytotoxic warburganal and related drimane-type sesquiterpenoids from Polygonum hydropiper. Phytochemistry. 21(12):2895-2898, 1982.
FUKUYAMA, Y.; SATO, T.; MIURA, I. and ASAKAWA, Y. - Drimane-type sesquiterpenoids and norsesquiterpenoids from Polygonum hydropiper. Phytochemistry, 24(7): 1521-1524, 1985.
FUKUYAMA, Y.; SATO, T.; MIURA, I.; ASAKAWA, Y. and TAKEMOTO, T. - Hydropiperoside, a novel coumaryl glycoside from the root of Polygonum hydropiper. - Phytochemistry, 22 (2): 549 - 552, 1983.
FURUTA, T.; FUKUYAMA, Y. and ASAKAWA, Y. - Polygonolide, an isocoumarin from Polygonum hydropiper possessing anti-inflammatory activity. Phytochemistry, 25(2):517-520,1986.
GOODMANN, L.S.M.A. and GILMAN, A. - As bases farmacológicas da terapêutica. 3a. ed., Ed. Guanabara Koogan, Rio de Janeiro, 1967,1529-1531 p.
HOEHNE, F.C. - Plantas e substâncias vegetais tóxicas e medicinais. 2a. ed., Novos Horizontes Ltda., São Paulo, 1978, 108-109 p.
PLUTA, J.; OLSZEWSKI, A. and ZABA, A. - Influence of physicochemical and technological agents on precipitate formation in the fluid extract of Polygonum hydropiper. Herba Pol., 31 (3/4): 201-208,1985 (1987), in: Biol. Abst., 85(11),114354, 1985 (1987).
SHALAMOVA, G.G.; YAKOVLEV, A.I. and CHURILOV, G.I. – Chemical composition of epigeal parts of 3 Polygonum spp. – Rastit Resur., 19(4): 526-529,1983, in: Biol, Abst., 28(9): 70800,
SWIATEK, L. and DOMBROWICZ, E. – Phenolic acids in medicinal plant drugs of Polygonum spp. – Farm. Pol.,43(7-8): 420-433,1987, Chem. Abst. 108, 156523g.
THOMSON, W.A.R. - Guia practico ilustrado de las plantas medicinales. Ed. Blume, Barcelona, 1981, 89 e 182p.
VYSOCHINA, G.I.; KUL'PINA, T.G. and BEREZOVSKAYA, T.P. - Flavonoid content in some Polygonum spp. of the section Persicari (Mill.) DC in the flora of Siberia. Rastit. Resur., 23 (2): 229-234,1987, in: Biol. Abst., 85(1):7746, 1987.
WILSON, R.H. and DE EDS, F. - The in vitro protection of epinephrine by flavonoids - J. Pharmac. Exp. Ther, 95,399-406, 1949, in: GOODMANN, L.S.M.A. and GILMAN, A. - As bases farmacológicas da terapêutica. 3a. ed., Ed. Guanabara Koogan, Rio de Janeiro, 1967, 1530p.
YAKOVL EV, A. I. and CHURILOV, G. I. - Characteristics and dynamics of polysaccharide content in Polygonum hydropiper epigeal parts. Rastit Resur., 19(1 ):68-71,1983, in: Biol. Abst. 77
(9): 70750,1983.
YUSIF, K.S. and BLINOVA, K.F. – Flavonol aglycons of Polygonum hydropiper. Khim. Frir. Soedin., (5), 658-659, 1984, in: Chem. Abstr. 102, 42886y, 1985.
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