Synergistic effect of Copaifera langsdorfii oil with essential oils for anti-inflammatory activity
DOI:
https://doi.org/10.5902/2179460X88048Keywords:
Copaifera langsdorffii, Synergism, Anti-inflammatoryAbstract
Copaifera langsdorffii essential oil belongs to the Leguminosae family and has anti-inflammatory, antibacterial, antifungal, analgesic, healing action, antiseptic, and antitumor potential, among others. Considering the importance of essential oils, this study aims to evaluate the total phenolic content, antioxidant and anti-inflammatory activity of Copaifera langsdorffii essential oil and its synergistic effect in association with essential oils of Aniba duckei Kostermans, Syzygium aromaticum (L.) Merr., Citrus limonia Osbeck, Citrus limettioides Tanaka, and Eucalyptus globulus Labill. Essential oils were extracted by hydrodistillation technique. The determination of the total phenolic compounds of the essential oil was performed by the Folin-Ciocalteu method. Antioxidant activity was assessed by the spectrophotometric method for eliminating hydroxyl radicals from salicylic acid, while anti-inflammatory activity was assessed by the protein denaturation method. The total phenolic content of Copaifera langsdorffii was 63.99 mg EAT g-1. The essential oil showed an antioxidant activity of EC50 16.67 mg L-1 being classified as active, as well as the anti-inflammatory potential, with EC50 52.46 mg L-1 also being classified as active. Finally, this study showed that the essential oil of Copaifera langsdorffii, as well as their synergies, have excellent antioxidant and anti-inflammatory potential.
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