Preliminary phytochemical study and antiproliferative activity of extracts from the plant Chloroleucon extortum Barneby & J. W. Grimes (Jurema Branca)
DOI:
https://doi.org/10.5902/2179460X88718Keywords:
Medicinal plants, Secondary metabolites, CytotoxicityAbstract
Due to the widespread use of medicinal plants and their derivatives in the daily lives of the world's population, a lack of knowledge about the bioactive compounds of many plant species still prevails because of the limited access to information and efforts to search for scientific evidence despite their widespread popular use. Therefore, the present work aims to conduct a phytochemical study of the species Chloroleucon Extortum Barneby & J. W. Grimes (Jurema Branca) and evaluate its cellular antiproliferative activity. As it is a plant native to the Brazilian Caatinga, phytochemical tests made it possible to observe the presence of secondary metabolites such as tannins, phenolic compounds, and coumarins extracted using different techniques. Cytotoxic activity was evaluated against cell lines such as HCT-116 (human colorectal cancer), HL-60 (acute promyelocytic leukemia), HeLa (human cervical cancer), and NCI-H292 (human mucoepidermoid carcinoma of the lung) and PBMC (human peripheral blood mononuclear cells). Thus, the extracts indicated moderate cytotoxic activity.
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