Plants from the Brazilian Cerrado with antimycobacterial effect

Authors

DOI:

https://doi.org/10.5902/2179460X35764

Keywords:

Cerrado, Public Health, Tuberculosis

Abstract

Tuberculosis constitutes a serious public health problem because it has multi-resistant forms that require treatment that is both difficult and extensive. There is a need to develop new antimycobacterial compounds, and plants represent a source of therapeutic resources. This study analyzed antimycobacterial action in eight extracts from plants found in the Brazilian Cerrado. The results showed significant inhibitory concentrations in relation to Mycobacterium tuberculosis, especially from the extracts of Apuleia molaris and Ouratea spectabilis, both of which presented reduced cytotoxic effects. Fractionation revealed a hexane fraction of A. molaris with significant and promising activity regarding future in vivo assays.

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Author Biographies

Franciano Dias Pereira Cardoso, Universidade Federal de Tocantins, Palmas, TO

Mestrado em Ciências do Ambiente, Universidade Federal de Tocantins, Palmas, TO

Marcio Galdino dos Santos, Universidade Federal do Tocantins, Porto Nacional, TO

Professor associado da Fundação Universidade Federal do Tocantins, Campus Porto Nacional

Sergio de Albuquerque, Universidade de São Paulo, Ribeirão Preto, SP

Professor Titular da Universidade de São Paulo

Zumira Aparecida Carneiro, Centro Universitário Estácio, Ribeirão Preto, SP

Professora titular em parasitologia nos cursos de medicina e enfermagem do Centro Universitário Estácio de Ribeirão Preto

Aparecido Osdimir Bertolin, Universidade Federal do Tocantins, Porto Nacional, TO

Professor na Universidade Federal do Tocantins, Porto Nacional, TO

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Published

2019-11-12

How to Cite

Cardoso, F. D. P., dos Santos, M. G., Albuquerque, S. de, Carneiro, Z. A., & Bertolin, A. O. (2019). Plants from the Brazilian Cerrado with antimycobacterial effect. Ciência E Natura, 41, e37. https://doi.org/10.5902/2179460X35764

Issue

CIÊNCIA E NATURA, V. 41, 2019

Section

Biology (Plant-microorganism Interaction)

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To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.

 

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