Cytotoxicity and genotoxicity of aqueous and hydroalcoholic extracts from Gallesia Integrifolia (Spreng) Harms

Authors

DOI:

https://doi.org/10.5902/2179460X84759

Keywords:

Medicinal plant, Cytogenotoxicity, Mutagenicity, Allium cepa, RAPD

Abstract

Gallesia integrifolia (Spreng) Harms is a medicinal plant commonly known in Brazil as pau-d'alho. This large tree species belongs to family Phytolaccaceae, which is widely distributed in several Brazilian states. Studies carried out with extracts deriving from different parts of this plant have evidenced its acaricidal, larvicidal, antifungal and bactericidal properties, among others. Thus, given its potential to be used as therapeutic alternative, the aim of the current study was to assess the cytogenetic and mutagenic effect of G. integrifolia, based on using the Allium cepa system and Random Amplified Polymorphic DNA (RAPD) as analysis tools, as well as on germination assay conducted with Lactuca sativa L. Results have indicated that aqueous and hydroalcoholic extracts from G. integrifolia leaves presented cytotoxic, genotoxic and mutagenic effects at the tested concentrations. The herein observed effects may be associated with phytochemical agents found in the tested extracts, as well as emphasize the importance of raising awareness about the indiscriminate use of medicinal plants. Thus, future research should be conducted to help isolating and better understanding the structure of components capable of inhibiting cell division.

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Author Biographies

Sthefany Pereira Duarte, Universidade Federal Rural do Rio de Janeiro

Academic in pharmacy at the Federal Rural University of Rio de Janeiro (UFRRJ)

Alexia Barreto da Silveira, Universidade Federal Rural do Rio de Janeiro

Academic in pharmacy at the Federal Rural University of Rio de Janeiro (UFRRJ)

Caroline de Almeida Azevedo, Universidade Federal Rural do Rio de Janeiro

Pharmacist, graduated in pharmacy at Federal Rural University of Rio de Janeiro (UFRRJ)

Brena Guerra Paixão, Universidade Federal do Rio de Janeiro

Academic in pharmacy at the Federal Rural University of Rio de Janeiro (UFRRJ)

Matheus de Lima Rodrigues, Universidade Federal do Rio de Janeiro

Academic in pharmacy at the Federal Rural University of Rio de Janeiro (UFRRJ)

Saulo Tavares Abreu, Universidade Federal do Rio de Janeiro

Pharmacist, graduated in pharmacy at Federal Rural University of Rio de Janeiro (UFRRJ) and master’s student at the postgraduate program in Pharmacology and Medicinal Chemistry at the Federal University of Rio de Janeiro (UFRJ)

Jennifer Vieira Gomes, Universidade do Estado do Rio de Janeiro

Biologist, graduated in biological sciences from Federal Rural University of Rio de Janeiro (UFRRJ), Master in Biosciences from the State University of Rio de Janeiro (UERJ) and doctoral student in the postgraduate program in Bioscience at the State University of Rio de Janeiro (UERJ)

Helcio Resende Borba, Universidade Federal do Rio de Janeiro

Biologist and Pharmacist, PhD in Veterinary Sciences (UFRRJ) and Full Professor form the Federal Rural University of Rio de Janeiro (UFRRJ)

Viviane Moreira Lima, Universidade Federal do Rio de Janeiro

Biologist, Douctor's in Biological Sciences (genetic) from the Federal University of Rio de Janeiro (UFRJ) and Associate Professor at the Federal Rural University of Rio de Janeiro (UFRRJ).

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Published

2024-07-29

How to Cite

Duarte, S. P., Silveira, A. B. da, Azevedo, C. de A., Paixão, B. G., Rodrigues, M. de L., Abreu, S. T., Gomes, J. V., Borba, H. R., & Lima, V. M. (2024). Cytotoxicity and genotoxicity of aqueous and hydroalcoholic extracts from Gallesia Integrifolia (Spreng) Harms. Ciência E Natura, 46, e84759. https://doi.org/10.5902/2179460X84759

Issue

Vol. 46 (2024): Publicação contínua

Section

Biology-Genetics

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