Oral Administration of N-acetylcysteine Improves Biochemical Parameters in Diabetic Rats

Jamile Fabbrin Gonçalves, Cinthia Melazzo Mazzanti, Alexssandro Geferson Becker, Rosilene Rodriguez Kaizer, Vanessa Battisti, Maísa de Carvalho Corrêa, Paula Acosta Maldonado, Roberta Schmatz, Gustavo Roberto Thomé, Vera Maria Morsch, Maria Rosa Chitolina Schetinger

Abstract


To evaluate the effect of N-acetylcysteine (NAC), a potent ROS scavenger and thiol group supplier, on normoglycemic and diabetic rats, the animals received 50 or 200 mg/kg NAC by gavage daily for 45 days. The results showed a lack of uniformity in acetylcholinesterase activity among the four cerebral structures. While neither dose of NAC produced significant hypoglycemic activity, 50 mg/kg NAC partially reverted the weight loss of diabetics and was effective in restoring aminolevulinate dehydratase activity and non-protein thiol content in liver, and in diminishing serum protein carbonylation. The dose of 200 mg/kg NAC presented some negative effects per se in both the antioxidant and cholinergic systems. In conclusion, 50 mg/kg NAC produced an improvement in some parameters suggesting NAC as a possible drug in antioxidant therapies against diabetic state. However, future studies are necessary to investigate the better dose of this compound to counteract its undesirable effects.




DOI: https://doi.org/10.5902/2179460X9356

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