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Mathematical modeling in quantification of [18F] FDG positron emission tomography images

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DOI:

https://doi.org/10.5902/2179460X66979

Palavras-chave:

Radiotracer, positron emission tomography (PET), reference region, kinetic modeling.

Resumo

Techniques for locating and quantifying brain glucose metabolism using compartmental modeling by solving systems of differential equations ordinary require an input function (input function), Ca(t). To avoid invasive procedures, such as collecting arterial blood samples, it is possible to obtain Ca(t) of the first order ordinary differential equation Cr´(t) = K1Ca(t)-K2Cr(t), where Cr(t) describes the concentration of the radiopharmaceutical in a reference region. Cr(t) is built from data obtained by processing images generated by positron emission tomography (PET) with radiotracers. In this work, the carotids were chosen as the reference region, and regression techniques were applied seeking to adjust the discrete activity curves (TAC) data obtained by PET imaging with the radiopharmaceutical fluorodeoxyglucose [18F]FDG. Aiming to find the same model type for all patients, the picewise linear function proved to be adequate to describe four stages of the behavior of the Cr(t) concentration: rapid growth and degrowth, intermediate and slow degrowths.

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Biografia do Autor

Nadine Skolaude Timm, Pontifícia Universidade Católica do Rio Grande do Sul - Escola Politécnica

Nadine Skolaude Timm, student of Chemical Engineering (PUCRS).

Eliete Biasotto Hauser, Pontifícia Universidade Católica do Rio Grande do Sul - Escola Politécnica

Eliete Biasotto Hauser, Master in Mathematics, PhD in Applied Mathematics, PhD in Mechanical Engineering (UFRGS). Full Professor at the School of Technology (PUCRS) . Researcher in Applied Mathematics of the Brain Institute of Rio Grande do Sul (BraIns). 

Referências

Borelli, W. V. (2019). Correlação Entre Neuroimagem Molecular, Estrutural e Funcional em Superidosos. 143 f. Thesis (Doctorate) Programa de Pós-Graduação de Medicina e Ciências da Saúde da Pontifícia Universidade Católica do Rio Grande do Sul. Porto alegre.

Hauser,E.B.,Venturini,G.T.,Greggio,S.,Borelli,W.V.,Costa,J.C.(2019).Carotidarterialinputfunctionasaninverseproblem in kinetic modeling of [18]2−fluoro−2deoxy−Dglucose(FDG). Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization, 8, 2168-1171.

Hauser, E. B., Borelli, W. V., Costa, J. C. (2020). Biomechanical Model Improving Alzheimer’s. Disease. In: Redha Taiar, editor. Recent Advances in Biomechanics 77–91.Intech Open.

Oliveira, F. (2019). Modelo Logístico para Descrever as Atividades de Curvas Discretas Obtidas de Imagens PET com Radiofármaco[18F]FDGnumVolumedeInteressedasCarótidas.. 28 f. Dissertation (Lato sensu) Pontifícia Universidade Católica do Rio Grande do Sul Porto Alegre.

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Publicado

2021-11-08 — Atualizado em 2022-04-06

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Timm, N. S., & Hauser, E. B. (2022). Mathematical modeling in quantification of [18F] FDG positron emission tomography images. Ciência E Natura, 43, e6. https://doi.org/10.5902/2179460X66979 (Original work published 8º de novembro de 2021)

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