Evaluation of the oxidative and inflammatory profile of patients with migraine

Autores

DOI:

https://doi.org/10.5902/2179460X43366

Palavras-chave:

Headaches, Migraine, Oxidative stress, Neutrophil/lymphocyte ratio

Resumo

Among one of the most commonly seen and primary headaches is migraine. Oxidative stress and inflammation is discussed to be implicated in the pathogenesis of migraine. However, further knowledge about this issue is necessary because data are in part controversial and the possible underlying mechanisms remain inconclusive to date. To evaluate and compare the oxidative and inflammatory profile of patients with migraine 47 volunteers were divided into 3 groups: 15 women with chronic migraine (WCM); 17 women with episodic migraine (WEM) and 15 men with migraine (MM) and enrolled in this study.Total antioxidant status; the enzymatic activity of the antioxidant agents Catalase (CAT), Glutathione S-transferase (GST) and Superoxide Dismutase (SOD); oxidative stress markers malondialdehyde (MDA) and carbonylated proteins; blood count and neutrophil/lymphocyte ratio; uric acid, c-reactive protein and cholesterol total and fractions were determined in pacients with migraine in the interictal phase. The group male participants (MM) displayed a reduction in total antioxidant status, as well as a lower value for antioxidant enzymes, but had no significant alterations in markers related to damage by oxidative stress compared to women. These findings suggest that there is a difference in the oxidative profile between the sexes among migraine patients. This may allow a better understanding of patients profile with different migraine phenotypes and identify new markers that might help understanding the pathophysiology and migraine patient management.

Downloads

Não há dados estatísticos.

Biografia do Autor

Aline Vasconcellos Martins Vaz, Divisão de Saúde Ambulatorial Universidade Federal de Viçosa

Mestre em Ciências da Saúde, programa de Pós-graduação em Ciências da Saúde, Departamento de Medicina e Enfermagem - DEM. Universidade Federal de Viçosa - UFV.

Silvia Almeida Cardoso, Departamento de Medicina e Enfermagem - DEM. Universidade Federal de Viçosa - UFV.

Professora da Universidade Federal de Viçosa, departamento de Enfermagem e Medicina (DEM-UFV).

Leandro Licursi de Oliveira, Departamento de Biologia Geral (DBG). Universidade Federal de Viçosa - UFV.

Professor da Universidade Federal de Viçosa, Departamento de Biologia Geral (DBG). 

Rodrigo de Barros Freitas, Departamento de Medicina e Enfermagem - DEM. Universidade Federal de Viçosa - UFV.

Boutor em Bioquímica pela Universidade Federal de Viçosa - UFV.

Palloma Porto Almeida, Instituto Nacional do Câncer (INCA) no Laboratório de Bioinformática e Biologia Computacional (LBBC).

Mestre em Bioquímica pela Universidade Federal de Viçosa

Paula Dutra Ribeiro, Departamento de Biologia Geral (DBG). Universidade Federal de Viçosa - UFV.

Graduada em Ciências Biológicas.

Daniel Silva Sena Bastos, Departamento de Biologia Geral (DBG). Universidade Federal de Viçosa - UFV.

Boutor em Biologia Celular e Estrutural pelo Universidade Federal de Viçosa - UFV.

Lucas Vilas Bôas Magalhães, Departamento de Medicina e Enfermagem - DEM. Universidade Federal de Viçosa - UFV.

Professor da Universidade Federal de Viçosa, departamento de Enfermagem e Medicina (DEM-UFV).

Referências

Abu Bakar N, Tanprawate S, Lambru G et al. (2016) Quality of life in primary headache disorders: a review. Cephalalgia 36(1):67-91. https://doi.org/10.1177/03331 0241558 0099.

Aebi H (1984) Catalase in vitro. Methods Enzymol 105:121-126. doi:10.1016/S0076-6879(84)05016-3.

Alp R, Selek S, Alp SI et al (2010) Oxidative and antioxidative balance in patients of migraine. Eur Rev Med Pharmacol Sci. 14(10):877-882.

Avijgan M (2011) Migraine Headache and Iron Deficiency Anemia. Nursing Faculty Journal of Iranian University of Medical Sciences. 23:37-43.

Aytaç B, Coşkun Ö, Alioğlu B et al. (2014) Decreased antioxidant status in migraine patients with brain white matter hyperintensities. Neurol Sci. 35(12):1925-1929.

Azab B, Bhatt VR, Phookan J et al. (2012) Use- fulness of the neutrophil-to-lymphocyte ratio in predicting short- and long- term mortality in breast cancer patients, Ann. Surg. Oncol. 19(1):217-224.

Bahadir A, Eroz R, Dikici S (2013) Investigation of MTHFR C677T Gene Polymorphism, Biochemical and Clinical Parameters in Turkish Migraine Patients: Association with Allodynia and Fatigue. Cell Mol Neurobiol. 33(8): 1055-1563. https://doi.org/10.1007/s10571-013-9972-1.

Bannister JV, Calabrese L (1987) Assays for SOD. Methods Biochem Anal 32:279–312. doi:10.1002/9780470110539.ch5.

Bernecker, C, Ragginer, C, Fauler, G et al. (2011). Oxidative stress is associated with migraine and migraine-related metabolic risk in females. European journal of neurology : the official journal of the European Federation of Neurological Societies. 18. 1233-9. 10.1111/j.1468-1331.2011.03414.x.

Borkum JM (2016) Migraine triggers and oxidative stress: a narrative review and synthesis. Headache 56(1):12-35. https://doi.org/10.1111/head.12725.

Bradford MM (1976) A rapid and sensitive methods for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem. 72:248-254.

Ceylan M, Bayraktutan OF, Becel S et al. (2016) Serum levels of pentraxin-3 and other inflammatory biomarkers in migraine: association with migraine characteristics. Cephalalgia 36(6):518-525. https://doi.org/10.1177/0333102415598757.

CHARLES, A. Migraine (1070) The New England Journal of Medicine 10:377:553-561. https://doi.org/10.1056/NEJMcp1605502.

Ciancarelli I, Tozzi-Ciancarelli MG, Spacca G et al. (2007) Relationship between biofeedback and oxidative stress in patients with chronic migrane. Cephalalgia 27:1136-1141.

Cordero MD, Cano-García FJ, Alcocer-Gómez E et al. (2012) Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement. PLoS One 7:e35677. https://doi.org/10.1371/journal.pone. 0035677.

Costa SC, Passos IC, Réus GZ et al (2016) The Comorbidity of bipolar disorder and migraine: the role of inflammation and oxidative and nitrosative stress. Curr. Mol. Med. 16(2):179-86.

Dodick DW (2018) Migraine. The Lancet. 31:391:1315-1330. https://doi.org/10. 1016/S0140-6736(18)30478-1.

Draper HH, Hadley M (1990) Malondialdehyde determination as index of lipid peroxidation. Methods Enzymol 186:421-431. doi:10.1016/0076-6879(90)86135-I.

ENGSTROM, M.; HAGEN, K.; BJORK, M. et al. (2013) Sleep-related and non-sleep-related migraine: interictal sleep quality, arousals and pain thresholds. J Head and Pain 14:68, 2013. doi: 10.1186/1129-2377-14-68.

Erel O. (2004) A novel automated method to measure total antioxidant response against potent free radical reactions. Clin Biochem. 37(2):112-119.

Eryigit U, Altunayoglu Cakmak V, Sahin A et al. (2017) The diagnostic value of the neutrophil-lymphocyte ratio in distinguishing between subarachnoid hemorrhage and migraine. Am J Emerg Med. 35(9):1276-1280.

https://doi.org/10.1016/j.ajem.2017. 03.063.

Fernández-de-las-Peñas C, Palacios-Ceña D, Salom-Moreno J et al (2014) Has the Prevalence of Migraine Changed over the Last Decade (2003-2012) A Spanish Population-Based Survey. PLoS One 9:e110530. https://doi.org/10.1371/journal. pone.0110530.

Geyik S, Altunisik E, Neyal AM et al (2016) Oxidative stress and DNA damage in patients with migraine. J Headache Pain 17:10. https://doi.org/10.1186/s10194-016-0606-0.

Goadsby P (2012) Pathophysiology of migraine. Ann Indian Acad Neurol. 15:15. https://doi.org/10.4103/0972-2327.99993.

Gomez D, Farid S, Malik H.Z et al. (2008) Preoperative neutrophil-to-lymphocyte ratio as a prognostic predictor after curative resection for hepatocellular carcinoma. World J. Surg. 32(8):1757-1762.

Gudmundsson LS, Aspelund T, Scher AI et al. (2009) C-reactive protein in migraine sufferers similar to that of non-migraineurs: the Reykjavik Study. Cephalalgia 29(12):1301-1310.

Gupta R, Pathak R, Bhatia MS et al. (2009) Comparison of oxidative stress among migraineurs, tension-type headache subjects, and a control group. Ann Indian Acad Neurol. 12(3):167-172.

Habig WH; Pabst MJ; Jackoby WB (1974) Glutathione-s-transferease. The first enzymatic step in mercapturic acid formation J. Biol Chem. 249:7130-7139.

Hayes JD, Strange RC (1995) Potential contribution of the glutathione S-transferase supergene family to resistance to oxidative stress. Free Radic Res 22:193-207.

Karabulut KU, Egercioglu TU, Uyar M et al. (2016) The change of neutrophils/lymphocytes ratio in migraine at- tacks: a case-controlled study. Ann Med Surg. (Lond)10:52–56. https://doi.org/10.1016/j.amsu.2016.07.023.

Kjersti Grøtta Vetvik and E Anne MacGregor, Sex differences in the epidemiology, clinical features, and pathophysiology of migraine, The Lancet Neurology, 10.1016/S1474-4422(16)30293-9, 16, 1,(76-87), (2017).

Levine RL, Garland D, Oliver CN et al. (1990) Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol 186:464-478. doi:10.1016/0076-6879(90)86141-H.

Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275.

Mannervik B (1985) The isozymes of glutathione transferase. Adv Enzymol Relat Areas Mol Biol. 57:357-417.

Moskowitz MA, Cutrer FM (1993) Sumatriptan: a receptor-targeted for migraine. Annu. Rev. Med. 44:145-154.

Neri M, Frustaci A, Milic M et al (2015) A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine. Cephalalgia 35:931937.

https://doi.org/10.1177/0333102414564888.

Neyal M, Yimenicioglu F, Aydeniz A et al (2013) Plasma nitrite levels, total antioxidant status, total oxidant status, and oxidative stress index in patients with tension-type headache and fibromyalgia. Clin Neuroleurosurg. 115(6):736-740. https://doi.org/10.1016/j.clineuro.2012.08.028.

Odegard SS, Engstrom M, Sand T, Stovner LJ et al. (2010) Associations between sleep disturbance and primary headaches: the third Nord-Trøndelag Health Study. J Headache Pain 11:197-206. https://doi.org/10.1007/s10194-010-0201-8.

Oh K, Cho S-J, Chung YK et al (2014) Combination of anxiety and depression is associated with an increased headache frequency in migraineurs: a population-based study. BMC Neurol. 14:238. https://doi.org/10.1186/s12883-014-0238-4.

Pamuk GE, Top MŞ, Uyanık MŞ et al (2015) Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression? Wien Klin Wochenschr. 128(8):576-580. https://doi.org/10.1007/s00508-015-0740-8.

Pizza V, Cassano D, Busillo V et al (2015) P073. Impaired oxidative balance in migraine: an open study. J Headache Pain 16:A115. https://doi.org/10.1186/1129-2377-16-S1-A115.

Rajendran P, Nandakumar N, Rengarajan T et al (2014) Antioxidants and human diseases. Clin Chim Acta 436:332-347. https://doi.org/10.1016/j.cca.2014.06.004.

Silberstein SD, Dodick DW, Bigal ME et al. (2017) Fremanezumab for the Preventive Treatment of Chronic Migraine. N Engl J Med 377:2113-22. DOI: 10.1056/NEJMoa1709038.

SONG, T.-J.; CHO. S.-J.; KIM, W.-J. et al. (2016) Anxiety and depression in probable migraine: A population-based study. Cephalalgia 37:845-854. https://doi. org/10.1177/0333102416653235.

Steiner TJ, Buse DC, Al Jumah M et al. (2018) The headache under-response to treatment (HURT) questionnaire, an outcome measure to guide follow-up in primary care: development, psychometric evaluation and assessment of utility. J Headache Pain 19:15. https://doi.org/10.1186/s10194-018-0842-6.

Stovner L, Hagen K, Jensen R et al. (2007) The Global Burden of Headache: A Documentation of Headache Prevalence and Disability Worldwide. Cephalalgia 27:193-210. https://doi.org/10.1111/j.1468-2982.2007.01288.x.

Turan H, Horasanli B, Ugur M et al. (2011) Procalcitonin levels in migraine patients, Can. J. Neurol. Sci. 38(1)124-128.

Vanmolkot FH, de Hoon JH (2007) Increased C-reactive protein in young adult patients with migraine. Cephalalgia 27:843-846.

Vos T, Allen C, Arora M et al. (2015) Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990-2015: a systematic analysis for the Global Burden of Disease Study. Lancet 388:1545-1602. https://doi.org/10.1016/S0140-6736(16)31678-6

Vurucu S, Karaoglu A, Paksu M et al. (2013) Relationship between oxidative stress and chronic daily headache in children. Hum Exp Toxicol. 32:113-119. https://doi.org/10.1177/0960327112459204

Yigit M, Sogut O, Tataroglu Ö et al. (2018) Oxidative/antioxidative status, lymphocyte DNA damage, and urotensin-2 receptor level in patients with migraine attacks. Neuropsychiatric Disease and Treatment 14:367-374. https://doi.org/10.2147/NDT.S156710

Yilmaz N, Aydin O, Yegin A et al. (2011) Increased levels of total oxidant status and decreased activity of arylesterase in migraineurs.

Publicado

2021-05-18 — Atualizado em 2022-04-06

Versões

Como Citar

Vaz, A. V. M., Cardoso, S. A., Oliveira, L. L. de, Freitas, R. de B., Almeida, P. P., Ribeiro, P. D., Bastos, D. S. S., & Magalhães, L. V. B. (2022). Evaluation of the oxidative and inflammatory profile of patients with migraine. Ciência E Natura, 43, e6. https://doi.org/10.5902/2179460X43366 (Original work published 18º de maio de 2021)

Artigos mais lidos pelo mesmo(s) autor(es)