The consumption of ora-pro-nobis and tamarillo improves which health indicators?
DOI:
https://doi.org/10.5902/2179460X87814Keywords:
Pereskia aculeata, Solanum betaceum, Unconventional food plants, Dietetics, Clinical practiceAbstract
Ora-pro-nobis and tamarillo are unconventional food plants (UFP) in Brazil rich in nutrients and fiber, which can exert positive effects on health. The objective was to analyze studies to verify the effectiveness and applicability of these UFPs in clinical practice. The Prisma protocol was used for data search. Four databases (PubMed, Cochrane, Embase, and Web of Science) were searched using compiled terms and Boolean operators “AND” / “OR.” Rayann was used to select the studies. The Joanna Briggs manual was adopted to assess the study's risk of bias. Thus, 17 studies were included in this review. Most studies (14/17) had a low, 2 moderate, and 1 high risk of bias. In conclusion, ora-pro-nobis and tamarillo exert beneficial effects on the lipid profile. Tamarillo improves antioxidant capacity, besides exerting positive effects on lipid and glycemic profiles, memory, and anticarcinogenic action, while ora-pro-nobis acted in gastrointestinal modulation, lipid profile, body weight reduction, satiety increase, and improving rheumatoid arthritis. To improve health indicators, we suggest daily consumption of 100 g of fresh leaves or 10 g of ora-pro-nobis flour; and/or 100 g of tamarillo.
Downloads
References
Abdul Kadir, N. A. A., Rahmat, A., & Jaafar, H. Z. (2015). Protective Effects of Tamarillo (Cyphomandra betacea) Extract against High Fat Diet Induced Obesity in Sprague‐Dawley Rats. Journal of obesity, 2015(1), 846041. doi: 10.1155/2015/846041 DOI: https://doi.org/10.1155/2015/846041
Agostini-Costa, T. S., Pêssoa, G. K. A., Silva, D. B., Gomes, I. S., & Silva, J. P. (2014). Carotenoid composition of berries and leaves from a Cactaceae–Pereskia sp. Journal of functional foods, 11, 178-184. doi: 10.1016/J.JFF.2014.09.015 DOI: https://doi.org/10.1016/j.jff.2014.09.015
Asih, I. A. R. A., Manuaba, I. B. P., Berata, K., & Satriyasa, B. K. (2018). The flavonoid glycosides antioxidant from terong Belanda (Solanum betaceum). Biomedical and Pharmacology Journal, 11(4), 2135-2141. DOI: https://doi.org/10.13005/bpj/1593
Bacchetti, T., Turco, I., Urbano, A., Morresi, C., & Ferretti, G. (2019). Relationship of fruit and vegetable intake to dietary antioxidant capacity and markers of oxidative stress: A sex-related study. Nutrition, 61, 164-172. doi: 10.1016/J.NUT.2018.10.034 DOI: https://doi.org/10.1016/j.nut.2018.10.034
Barbalho, S. M., Guiguer, É. L., Marinelli, P. S., Santos Bueno, P. C. dos., Pescinini-Salzedas, L. M., Santos, M. C. B. dos, Oshiiwa, M., Mendes, C. G., Menezes, M. L. de., Nicolau, C. C. T., Otoboni, A. M., & Alvares Goulart, R. de. (2016). Pereskia aculeata Miller flour: metabolic effects and composition. Journal of medicinal food, 19(9), 890-894. doi: 10.1089/JMF.2016.0052 DOI: https://doi.org/10.1089/jmf.2016.0052
Barbosa, D. M., Santos, G. M. C. dos, Gomes, D. L., Costa Santos, É. M. da, Silva, R. R. V. da, & Medeiros, P. M. de. (2021). Does the label ‘unconventional food plant ’influence food acceptance by potential consumers? A first approach. Heliyon, 7(4), e06731. doi: 10.1016/J.HELIYON.2021.E06731 DOI: https://doi.org/10.1016/j.heliyon.2021.e06731
Barreira, T. F., Paula, G. X. D. Filho, Priore, S. E., Santos, R. H. S., & Pinheiro-Sant’ana, H. M. (2020). Nutrient content in ora-pro-nóbis (Pereskia aculeata Mill.): unconventional vegetable of the Brazilian Atlantic Forest. Food Science and Technology, 41(suppl 1), 47-51. doi: 10.1590/fst.07920 DOI: https://doi.org/10.1590/fst.07920
Bianchi, F., Duque, A. L. R. F., Saad, S. M. I., & Sivieri, K. (2019). Gut microbiome approaches to treat obesity in humans. Applied microbiology and biotechnology, 103(3), 1081-1094. doi: 10.1007/S00253-018-9570-8 DOI: https://doi.org/10.1007/s00253-018-9570-8
Birari, R. B., & Bhutani, K. K. (2007). Pancreatic lipase inhibitors from natural sources: unexplored potential. Drug discovery today, 12(19-20), 879-889. doi: 10.1016/J.DRUDIS.2007.07.024 DOI: https://doi.org/10.1016/j.drudis.2007.07.024
Brasil, D. C. M., Val, R. M. M. D., Ramos, J. A. D. S. C., & Almeida, M. E. F. D. (2020). Juice from leaves of cacti of the genus Pereskia: effect on the physiological parameters of Wistar rats. Ciência Animal Brasileira, 21, e58061. doi: 10.1590/1809-6891v21e-58061 DOI: https://doi.org/10.1590/1809-6891v21e-58061
Chen, Y., Liu, K., Qin, Y., Chen, S., Guan, G., Huang, Y., Chen, Y., & Mo, Z. (2022). Effects of Pereskia aculeate miller petroleum ether extract on complete Freund’s adjuvant-induced rheumatoid arthritis in rats and its potential molecular mechanisms. Frontiers in Pharmacology, 9(13), 869810. doi: 10.3389/fphar.2022.869810 DOI: https://doi.org/10.3389/fphar.2022.869810
Chutkan, R., Fahey, G., Wright, W. L., & McRorie, J. (2012). Viscous versus nonviscous soluble fiber supplements: mechanisms and evidence for fiber-specific health benefits. Journal of the American Association of Nurse Practitioners, 24(8), 476-487. doi: 10.1111/J.1745-7599.2012.00758.X DOI: https://doi.org/10.1111/j.1745-7599.2012.00758.x
Cianciosi, D., Forbes-Hernández, T. Y., Regolo, L., Alvarez-Suarez, J. M., Navarro-Hortal, M. D., Xiao, J., Quiles, J. L., Battino, M., & Giampieri, F. (2022). The reciprocal interaction between polyphenols and other dietary compounds: Impact on bioavailability, antioxidant capacity and other physico-chemical and nutritional parameters. Food Chemistry, 375, 131904. doi: 10.1016/J.FOODCHEM.2021.131904 DOI: https://doi.org/10.1016/j.foodchem.2021.131904
Costamagna, M. S., Zampini, I. C., Alberto, M. R., Cuello, S., Torres, S., Pérez, J., Quispe, C., Schmeda-Hirschmann, G., & Isla, M. I. (2016). Polyphenols rich fraction from Geoffroea decorticans fruits flour affects key enzymes involved in metabolic syndrome, oxidative stress and inflammatory process. Food chemistry, 1(190), 392-402. doi: 10.1016/J.FOODCHEM.2015.05.068 DOI: https://doi.org/10.1016/j.foodchem.2015.05.068
Cruz, T. M., Santos, J. S., Carmo, M. A. V. do, Hellström, J., Pihlava, J. M., Azevedo, L., Granato, D., & Marques, M. B. (2021). Extraction optimization of bioactive compounds from ora-pro-nobis (Pereskia aculeata Miller) leaves and their in vitro antioxidant and antihemolytic activities. Food chemistry, 361, 130078. doi: 10.1016/J.FOODCHEM.2021.130078 DOI: https://doi.org/10.1016/j.foodchem.2021.130078
Demirci-Cekic, S., Özkan, G., Avan, A. N., Uzunboy, S., Çapanoğlu, E., & Apak, R. (2022). Biomarkers of oxidative stress and antioxidant defense. Journal of pharmaceutical and biomedical analysis, 209, 114477. doi: 10.1016/J.JPBA.2021.114477 DOI: https://doi.org/10.1016/j.jpba.2021.114477
Diep, T. T., Pook, C., & Yoo, M. J. Y. (2020). Physicochemical properties and proximate composition of tamarillo (Solanum betaceum Cav.) fruits from New Zealand. Journal of food composition and analysis, 92, 103563. doi: 10.1016/J.JFCA.2020.103563 DOI: https://doi.org/10.1016/j.jfca.2020.103563
Eberhardt, M. V., & Jeffery, E. H. (2006). When dietary antioxidants perturb the thiol redox. Journal of the Science of Food and Agriculture, 86(13), 1996–1998. doi: 10.1002/JSFA.2617 DOI: https://doi.org/10.1002/jsfa.2617
Farhat, G., Drummond, S., & Al‐Dujaili, E. A. (2017). Polyphenols and their role in obesity management: a systematic review of randomized clinical trials. Phytotherapy research, 31(7), 1005-1018. doi: 10.1002/PTR.5830 DOI: https://doi.org/10.1002/ptr.5830
Gannasin, S. P., Mustafa, S., Adzahan, N. M., & Muhammad, K. (2015). In vitro prebiotic activities of tamarillo (Solanum betaceum Cav.) hydrocolloids. Journal of Functional Foods, 19, 10-19. doi: 10.1016/J.JFF.2015.09.004 DOI: https://doi.org/10.1016/j.jff.2015.09.004
Garcia, J. A., Corrêa, R. C., Barros, L., Pereira, C., Abreu, R. M., Alves, M. J., Calhelha, R. C., Bracht, A., Peralta, R. M., & Ferreira, I. C. (2019). Phytochemical profile and biological activities of'Ora-pro-nobis' leaves (Pereskia aculeata Miller), an underexploited superfood from the Brazilian Atlantic Forest. Food chemistry, 294, 302-308. doi: 10.1016/J.FOODCHEM.2019.05.074 DOI: https://doi.org/10.1016/j.foodchem.2019.05.074
García, J. M., Giuffrida, D., Dugo, P., Mondello, L., & Osorio, C. (2018). Development and characterisation of carotenoid-rich microencapsulates from tropical fruit by-products and yellow tamarillo (Solanum betaceum Cav.). Powder technology, 339, 702-709. doi: 10.1016/J.POWTEC.2018.08.061 DOI: https://doi.org/10.1016/j.powtec.2018.08.061
Ghani, U. (2015). Re-exploring promising α-glucosidase inhibitors for potential development into oral anti-diabetic drugs: Finding needle in the haystack. European journal of medicinal chemistry, 103, 133-162. doi: 10.1016/J.EJMECH.2015.08.043 DOI: https://doi.org/10.1016/j.ejmech.2015.08.043
Grove, K. A., Sae‐Tan, S., Kennett, M. J., & Lambert, J. D. (2012). Epigallocatechin‐3‐gallate inhibits pancreatic lipase and reduces body weight gain in high fat‐fed obese mice. Obesity, 20(11), 2311-2313. doi: 10.1038/OBY.2011.139 DOI: https://doi.org/10.1038/oby.2011.139
Joanna Briggs Institute. (2020). JBI Manual for Evidence Synthesis. https://doi.org/10.46658/JBIMES-20-01 DOI: https://doi.org/10.46658/JBIMES-20-01
Khaerunnisa, S., Kusumastuti, K., Mustika, A., & Aminah, N. S. (2019). Mechanism of Solanum betaceum to prevent memory impairment in cigarette smoke-exposed rat. International Journal of Applied Pharmaceutics, 11(3), 25-29. doi: 10.22159/IJAP.2019.V11S3.M1024 DOI: https://doi.org/10.22159/ijap.2019.v11s3.M1024
Kou, M. C., Yen, J. H., Hong, J. T., Wang, C. L., Lin, C. W., & Wu, M. J. (2009). Cyphomandra betacea Sendt. phenolics protect LDL from oxidation and PC12 cells from oxidative stress. LWT-Food Science and Technology, 42(2), 458-463. doi: 10.1016/J.LWT.2008.09.010 DOI: https://doi.org/10.1016/j.lwt.2008.09.010
Kumar, C. S., Sivakumar, M., & Ruckmani, K. (2016). Microwave-assisted extraction of polysaccharides from Cyphomandra betacea and its biological activities. International Journal of Biological Macromolecules, 92, 682-693. doi: 10.1016/J.IJBIOMAC.2016.07.062 DOI: https://doi.org/10.1016/j.ijbiomac.2016.07.062
Lin, R., Li, D., Xu, Y., Wei, M., Chen, Q., Deng, Y., & Wen, J. (2021). Chronic cereulide exposure causes intestinal inflammation and gut microbiota dysbiosis in mice. Environmental Pollution, 1(288), 117814. doi: 10.1016/J.ENVPOL.2021.117814 DOI: https://doi.org/10.1016/j.envpol.2021.117814
Liu, F., Liu, J., Liu, Y., Zhang, Y., & Ding, X. (2021). Decoction could ameliorate intestinal permeability by regulating the intestinal expression of tight junction proteins and p-VASP in septic rats. Journal of Ethnopharmacology, 268, 113562. doi: 10.1016/J.JEP.2020.113562 DOI: https://doi.org/10.1016/j.jep.2020.113562
Maciel, V. B. V., Yoshida, C. M. P., Boesch, C., Goycoolea, F. M., & Carvalho, R. A. (2018). Iron uptake by Caco-2 cells from a Brazilian natural plant extract loaded into chitosan/pectin nano-and micro-particles. [Abstract]. Proceedings of the Nutrition Society, Cambridge University Press. doi: 10.1017/s0029665118000393 DOI: https://doi.org/10.1017/S0029665118000393
Mariutti, L. R. B., Rebelo, K. S., Bisconsin, A. Jr., Morais, J. S. de, Magnani, M., Maldonade, I. R., Madeira, N. R., Tiengo, A., Maróstica, M. R. Jr., & Cazarin, C. B. B. (2021). The use of alternative food sources to improve health and guarantee access and food intake. Food Research International, 149, 110709. doi: 10.1016/J.FOODRES.2021.110709 DOI: https://doi.org/10.1016/j.foodres.2021.110709
Martin, D., Lopes, T., Correia, S., Canhoto, J., Marques, M. P. M., & Carvalho, L. A. B. de (2021). Nutraceutical properties of tamarillo fruits: A vibrational study. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 252, 119501. doi: 10.1016/J.SAA.2021.119501 DOI: https://doi.org/10.1016/j.saa.2021.119501
Muliarta, M., Tirtayasa, K., Prabawa, P. Y., & Wiryadana, K. A. (2020). Tamarillo Consumption Associated with Increased Acetylcholinesterase Activity and Improved Oxidative Stress Markers in Farmers Exposed to Daily Pesticide-related Activities in Baturiti, Bali, Indonesia. Open Access Macedonian Journal of Medical Sciences, 8(E), 244-250. doi: 10.3889/oamjms.2020.3265 DOI: https://doi.org/10.3889/oamjms.2020.3265
Mutalib, M. A., Ali, F., Othman, F., Ramasamy, R., & Rahmat, A. (2016). Phenolics profile and anti-proliferative activity of Cyphomandra betacea fruit in breast and liver cancer cells. SpringerPlus, 5, 1205. doi: 10.1186/S40064-016-3777-X DOI: https://doi.org/10.1186/s40064-016-3777-x
Nascimento, G. E. do, Corso, C. R., Paula Werner, M. F. de, Baggio, C. H., Iacomini, M., & Cordeiro, L. M. (2015). Structure of an arabinogalactan from the edible tropical fruit tamarillo (Solanum betaceum) and its antinociceptive activity. Carbohydrate Polymers, 13(116), 300-306. doi: 10.1016/j.carbpol.2014.03.032 DOI: https://doi.org/10.1016/j.carbpol.2014.03.032
Nascimento, G. E. do., Hamm, L. A., Baggio, C. H., Paula Werner, M. F. de, Iacomini, M., & Cordeiro, L. M. (2013). Structure of a galactoarabinoglucuronoxylan from tamarillo (Solanum betaceum), a tropical exotic fruit, and its biological activity. Food chemistry, 141(1), 510-516. doi: 10.1016/j.foodchem.2013.03.023 DOI: https://doi.org/10.1016/j.foodchem.2013.03.023
Nascimento, G. E. do, Iacomini, M., & Cordeiro, L. M. (2016). A comparative study of mucilage and pulp polysaccharides from tamarillo fruit (Solanum betaceum Cav.). Plant physiology and biochemistry, 104, 278-283. doi: 10.1016/J.PLAPHY.2016.04.055 DOI: https://doi.org/10.1016/j.plaphy.2016.04.055
Orqueda, M. E., Rivas, M., Zampini, I. C., Alberto, M. R., Torres, S., Cuello, S., Sayago, J., Thomasp-Valdes, S., Jiménez-Aspee, F., Schmeda-Hirschmann, G., & Isla, M. I. (2017). Chemical and functional characterization of seed, pulp and skin powder from chilto (Solanum betaceum), an Argentine native fruit. Phenolic fractions affect key enzymes involved in metabolic syndrome and oxidative stress. Food Chemistry, 1(216), 70-79. doi: 10.1016/J.FOODCHEM.2016.08.015 DOI: https://doi.org/10.1016/j.foodchem.2016.08.015
Orqueda, M. E., Torres, S., Zampini, I. C., Cattaneo, F., Di Pardo, A. F., Valle, E. M., Jiménez-Aspee, F., Schmeda-Hierschmann, G., & Isla, M. I. (2020). Integral use of Argentinean Solanum betaceum red fruits as functional food ingredient to prevent metabolic syndrome: Effect of in vitro simulated gastroduodenal digestion. Heliyon, 6(2), e03387. doi: 10.1016/J.HELIYON.2020.E03387 DOI: https://doi.org/10.1016/j.heliyon.2020.e03387
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., ... & Moher, D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372. doi: 10.1136/BMJ.N71 DOI: https://doi.org/10.1136/bmj.n71
Philippi, S. T., Latterza, A. R., Cruz, A. T. R., & Ribeiro, L. C. (1999). Pirâmide alimentar adaptada: guia para escolha dos alimentos. Revista de nutrição, 12(1), 65-80. doi: 10.1590/S1415-52731999000100006 DOI: https://doi.org/10.1590/S1415-52731999000100006
Pinto, N. D. C. C., Duque, A. P. D. N., Pacheco, N. R., Mendes, R. D. F., Motta, E. V. D. S., Bellozi, P. M. Q., Ribeiro, A., Salvador, M. J., & Scio, E. (2015). Pereskia aculeata: A plant food with antinociceptive activity. Pharmaceutical biology, 53(12), 1780-1785. doi: 10.3109/13880209.2015.1008144 DOI: https://doi.org/10.3109/13880209.2015.1008144
Raka, I. A., Asih, I. A. R. A., Manuaba, I. B. P., Berata, K., Komang, B., & Satriyasa, I. (2018). Intake Flavonoid Glycosides of Fruit Solanum betaceum in Its Activity as a Candidate of Anti-Stress Oxidative. International Journal of Pharmaceutical and Phytopharmacological Research (eIJPPR), 8(6), 1-7. https://eijppr.com/yX1t1yo
Reagan‐Shaw, S., Nihal, M., & Ahmad, N. (2008). Dose translation from animal to human studies revisited. The FASEB journal, 22(3), 659-661. doi: 10.1096/FJ.07-9574LSF DOI: https://doi.org/10.1096/fj.07-9574LSF
Sihombing, J. R., Sidabutar, C. A. B. S., Fachrial, E., Almahdy, A., Chaidir, Z., & Dharma, A. (2017). Utilization of Fruit Peel Extracts of Persea americana, Cyphomandra betacea, Mangifera odorata and Archidendron pauciflorum as Antidiabetic in Experimental Rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 8(1), 1407-1410. http://repository.uhn.ac.id/handle/123456789/7185
Salazar-Lugo, R., Barahona, A., Ortiz, K., Chávez, C., Freire, P., Méndez, J., Bermeo, B., Santamaria, M., Salas, H., & Oleas, M. (2016). Efecto del consumo de jugo de tomate de árbol (Cyphomandra betacea) sobre el perfil lipídico y las concentraciones de glucosa en adultos con hiperlipidemia, Ecuador. Archivos Latinoamericanos de Nutrición, 66(2), 121-128. https://medes.com/publication/110362
Santoso, M., Ong, L. L., Aijijiyah, N. P., Wati, F. A., Azminah, A., Annuur, R. M., Fadlan, A., & Judeh, Z. M. (2022). Synthesis, α-glucosidase inhibition, α-amylase inhibition, and molecular docking studies of 3, 3-di (indolyl) indolin-2-ones. Heliyon, 8(3), e09045. doi: 10.1016/J.HELIYON.2022.E09045 DOI: https://doi.org/10.1016/j.heliyon.2022.e09045
Scortichini, S., Boarelli, M. C., Silvi, S., & Fiorini, D. (2020). Development and validation of a GC-FID method for the analysis of short chain fatty acids in rat and human faeces and in fermentation fluids. Journal of Chromatography B, 1143, 121972. doi: 10.1016/J.JCHROMB.2020.121972 DOI: https://doi.org/10.1016/j.jchromb.2020.121972
Silva, D. O., Seifert, M., Nora, F. R., Bobrowski, V. L., Freitag, R. A., Kucera, H. R., Nora, L., & Gaikwad, N. W. (2017). Acute toxicity and cytotoxicity of Pereskia aculeata, a highly nutritious cactaceae plant. Journal of Medicinal Food, 20(4), 403-409. doi: 10.1089/JMF.2016.0133 DOI: https://doi.org/10.1089/jmf.2016.0133
Silveira, M. G., Picinin, C. T., Cirillo, M. A., Freire, J. M., & Barcelos, M. D. F. P. (2020). Nutritional assay Pereskia spp.: unconventional vegetable. Anais da Academia Brasileira de Ciências, 92(1), e20180757. doi: 10.1590/0001-3765202020180757 DOI: https://doi.org/10.1590/0001-3765202020180757
Soobrattee, M. A., Neergheen, V. S., Luximon-Ramma, A., Aruoma, O. I., & Bahorun, T. (2005). Phenolics as potential antioxidant therapeutic agents: mechanism and actions. Mutation Research/Fundamental and Molecular mechanisms of mutagenesis, 579(1-2), 200-213. doi: 10.1016/J.MRFMMM.2005.03.023 DOI: https://doi.org/10.1016/j.mrfmmm.2005.03.023
Takeiti, C. Y., Antonio, G. C., Motta, E. M., Collares-Queiroz, F. P., & Park, K. J. (2009). Nutritive evaluation of a non-conventional leafy vegetable (Pereskia aculeata Miller). International Journal of Food Sciences and Nutrition, 60(1), 148-160. doi: 10.1080/09637480802534509 DOI: https://doi.org/10.1080/09637480802534509
Terra, S. B., & Viera, C. T. R. (2019). Plantas Alimentícias Não Convencionais (PANCs): levantamento em zonas urbanas de Santana do Livramento, RS. Ambiência, 15(1), 112-130. doi: 10.5935/ambiencia.2019.01.07 DOI: https://doi.org/10.5935/ambiencia.2019.01.07
Torres, T. M. S., Álvarez-Rivera, G., Mazzutti, S., Sánchez-Martínez, J. D., Cifuentes, A., Ibáñez, E., & Ferreira, S. R. S. (2021). Neuroprotective potential of extracts from leaves of ora-pro-nobis (Pereskia aculeata) recovered by clean compressed fluids. The Journal of Supercritical Fluids, 179, 105390. doi: 10.1016/J.SUPFLU.2021.105390 DOI: https://doi.org/10.1016/j.supflu.2021.105390
Vieira, C. R., da Silva, B. P., do Carmo, M. A. V., Azevedo, L., Nogueira, D. A., Duarte Martino, H. S., & Silva, R. R. (2019). Effect of Pereskia aculeata Mill. in vitro and in overweight humans: A randomized controlled trial. Journal of food biochemistry, 43(7), e12903. doi: 10.1111/JFBC.12903 DOI: https://doi.org/10.1111/jfbc.12903
Vieira, C. R., Grancieri, M., Martino, H. S. D., César, D. E., & Barra, R. R. S. (2020). A beverage containing ora-pro-nobis flour improves intestinal health, weight, and body composition: A double-blind randomized prospective study. Nutrition, 78, 110869. doi: 10.1016/J.NUT.2020.110869 DOI: https://doi.org/10.1016/j.nut.2020.110869
Wang, S., & Zhu, F. (2020). Tamarillo (Solanum betaceum): Chemical composition, biological properties, and product innovation. Trends in Food Science & Technology, 95, 45-58. doi: 10.1016/j.tifs.2019.11.004 DOI: https://doi.org/10.1016/j.tifs.2019.11.004
Wang, Y., Yang, M., Lee, S. G., Davis, C. G., Koo, S. I., & Chun, O. K. (2012). Dietary total antioxidant capacity is associated with diet and plasma antioxidant status in healthy young adults. Journal of the Academy of Nutrition and Dietetics, 112(10), 1626-1635. doi: 10.1016/J.JAND.2012.06.007 DOI: https://doi.org/10.1016/j.jand.2012.06.007
Williams, R. J., Spencer, J. P., & Rice-Evans, C. (2004). Flavonoids: antioxidants or signalling molecules? Free radical biology and medicine, 36(7), 838-849. doi: 10.1016/J.FREERADBIOMED.2004.01.001 DOI: https://doi.org/10.1016/j.freeradbiomed.2004.01.001
Zhou, J. F., Wang, W. J., Yin, Z. P., Zheng, G. D., Chen, J. G., Li, J. E., Chen, L. L. & Zhang, Q. F. (2021). Quercetin is a promising pancreatic lipase inhibitor in reducing fat absorption in vivo. Food Bioscience, 43, 101248. doi: 10.1016/J.FBIO.2021.101248 DOI: https://doi.org/10.1016/j.fbio.2021.101248
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Ciência e Natura

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.
Ethical Guidelines for Journal Publication
The Ciência e Natura journal is committed to ensuring ethics in publication and quality of articles.
Conformance to standards of ethical behavior is therefore expected of all parties involved: Authors, Editors, Reviewers, and the Publisher.
In particular,
Authors: Authors should present an objective discussion of the significance of research work as well as sufficient detail and references to permit others to replicate the experiments. Fraudulent or knowingly inaccurate statements constitute unethical behavior and are unacceptable. Review Articles should also be objective, comprehensive, and accurate accounts of the state of the art. The Authors should ensure that their work is entirely original works, and if the work and/or words of others have been used, this has been appropriately acknowledged. Plagiarism in all its forms constitutes unethical publishing behavior and is unacceptable. Submitting the same manuscript to more than one journal concurrently constitutes unethical publishing behavior and is unacceptable. Authors should not submit articles describing essentially the same research to more than one journal. The corresponding Author should ensure that there is a full consensus of all Co-authors in approving the final version of the paper and its submission for publication.
Editors: Editors should evaluate manuscripts exclusively on the basis of their academic merit. An Editor must not use unpublished information in the editor's own research without the express written consent of the Author. Editors should take reasonable responsive measures when ethical complaints have been presented concerning a submitted manuscript or published paper.
Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.


