Análise de sobrevivência através de um método não-paramétrico
DOI:
https://doi.org/10.5902/2179460X40479Keywords:
Análise de sobrevivência, Kaplan MeierAbstract
Partindo do interesse em estudar as técnicas de Análise de Sobrevivência, efetuou-se a revisão de literatura direcionada a estimação de curvas de sobrevivência através do estimador não-paramétrico de Kaplan-Meier e testes para comparação entre curvas: Log-rank e Qui-quadrado. Analisou-se os dados de pacientes com câncer no aparelho digestivo do Hospital Universitário de Santa Maria. Na comparação dos pacientes, quanto ao tipo de cirurgia, não houve diferença significativa entre as curvas de sobrevivência. Quanto aos estágios da doença (I, II, III e IV), houve diferença significativa entre as curvas de sobrevivência do estágio I em relação ao estágio III e IV e estágio II em relação ao IV. Quanto ao tipo de tratamento curativo e paliativo, houve diferença significativa entre as curvas. Conclui-se que esses resultados de probabilidade de sobrevivência podem auxiliar o profissional da área da saúde na decisão pelo melhor tratamento para os seus pacientes.
Downloads
References
ALLISON, PD. Event history analysis. London: Sage University Paper 46, 1984.
ARMITAGE, P, BERRY, G. Statistical methods in medical research. USA:3 ed. Blackwell Science Ltda., 1994.
BAILAR III, JC,MOSTELLER, F. Medical uses of statistics. Boston: 2 ed. NEJM Book, 1992.
CHIESA, EMF. Análise de Sobrevivência através de um método não paramétrico [monography]. Santa Maria: Curso de Especialização em Estatística e Modelagem Quantitativa /UFSM; 2002.
COLOSIMO, EA. Análise de Sobrevivência Aplicada. In: Anais 9°, SEAGRO, REUNIÃO ANUAL DA RBRAS, 46ª, Piracicaba, SP. Brasil. 2001.
COX, DR. Regression models and life tables. Journal of the Royal Statistical Society B, 1972; v. 34, p.187-220.
COX, DR; OAKES, D. Analysis of survival data. London: Chapman and Hall, 1984.
ECHEVESTE, SS. Análise de sobrevivência: um estudo na área educacional [monography]. Porto Alegre: Instituto de Matemática, Departamento de Estatística/ UFRGS;1997.
ELANDT-JOHNSON, RC, JOHNSON, NL. Survival models and data analysis. New York: John Wiley and Sons, 1980.
FISCHER, LD., BELLE, GV. Biostatistics – A methodology for the heath sciences. New York: John Wiley & Sons, Inc., 1995.
HOSMER, DW Jr, LEMESHOW, S. Applied survival analysis – Regression modeling of time to event data. New York: John Wiley & Sons, Inc, 1998.
KALBFLEISCH, JD, PRENTICE, RL. The statistical analysis of failure time data. New York: John Wiley and Sons, 1980.
KAPLAN, EL., MEIER, P. Nonparametric estimation for incomplete observations. Journal of the American Statistical Association, 1958; v. 53, n.282, p.457-481.
KLEINBAUM, DG. Survival analysis – A self learning text. New York: Verlag New York, Inc, 1996.
LAWLESS, JF. Statistical models and methods for lifetime data. New York: John Wiley and Sons, 1982.
LE, CHAP T., Applied survival analysis. John Wiley & Sons, Inc. New York, 1997.
Excel. Microsoft Corporation. Quito, versão 7, 2001.
NELSON, W., Accelerated life testing: statistical models, data analysis and test plans. New York: John Wiley and Sons, 1990.
RODRIGUES, PC. Bioestatística. Niterói: 2 ed EDUFF, 1993.
SOARES, JF., COLOSIMO, EA. Métodos estatísticos na pesquisa clínica. In: Anais 6o, SEAGRO, REUNIÃO ANUAL DA RBRAS, 40o, Ribeirão Preto, SP. Brasil.1995.
STATISTICA for windows. Statsoft. Tulsa, 1998, versão 5.1.
Published
How to Cite
Issue
Section
License
To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.
Ethical Guidelines for Journal Publication
The Ciência e Natura journal is committed to ensuring ethics in publication and quality of articles.
Conformance to standards of ethical behavior is therefore expected of all parties involved: Authors, Editors, Reviewers, and the Publisher.
In particular,
Authors: Authors should present an objective discussion of the significance of research work as well as sufficient detail and references to permit others to replicate the experiments. Fraudulent or knowingly inaccurate statements constitute unethical behavior and are unacceptable. Review Articles should also be objective, comprehensive, and accurate accounts of the state of the art. The Authors should ensure that their work is entirely original works, and if the work and/or words of others have been used, this has been appropriately acknowledged. Plagiarism in all its forms constitutes unethical publishing behavior and is unacceptable. Submitting the same manuscript to more than one journal concurrently constitutes unethical publishing behavior and is unacceptable. Authors should not submit articles describing essentially the same research to more than one journal. The corresponding Author should ensure that there is a full consensus of all Co-authors in approving the final version of the paper and its submission for publication.
Editors: Editors should evaluate manuscripts exclusively on the basis of their academic merit. An Editor must not use unpublished information in the editor's own research without the express written consent of the Author. Editors should take reasonable responsive measures when ethical complaints have been presented concerning a submitted manuscript or published paper.
Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.
