Tolerance to methylxanthines and interaction with Dopaminergic System clinical implications
DOI:
https://doi.org/10.5902/2179460X26502Abstract
Recent studies have suggested that methylxanthines could change neuroleptics efficiency, since haloperidol or chlorpromazine-induced catalepsy is reversed by methylxanthines. However, these studies were made with acute administration of the drugs, disregarding the possible development of tolerance to methylxanthines. In the present mini-review of the literature it was observed that few studies investigated the tolerance to methylxanthines, furthermore there is some controversy between them. In our laboratory we found no tolerance to caffeine in relation to the etfect on the rat locomotor activity and its ability in reversing chlorpromazine-induced catalepsy. These results suggest that well-controled clinical studies with psychiatric patients in current use of both kinds of drugs are necessary to establish if methylxanthines actually change neuroleptics antipsychotic efficacy.Downloads
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