Jacaranda micrantha Cham.: isolation and identification of 1-hidroxy-4-oxo-2,5-ciclohexadien-1-ethylacetate. antitumor, antibacterial and antifungal analysis
DOI:
https://doi.org/10.5902/2179460X24978Abstract
A phytotoquinol from chloroform extract of leaves of Jacaranda micrantha Cham, leaves was photoquinol was isolated and identified as a 1-hydroxy-4-oxo-2,5-cyclohexadien-1 ethyl acetate compound.
The composition was analysed to check for possible antifungi and antibacteria activity. The tests resulted negative on Aspergillus niger fungi (ATCC 16404) and Candida albicans (ATCC 10231) but uncovered antibacterial activity against Staphyloccocus aureus (ATCC6538P) and Staphyloccocus aureus (ATCC 25923).
Chloroformic extract was tested as to its antineoplasic activity. The test resulted negative.
Downloads
References
BOHLMANN, F. & KNOLL, K. New acetylenic compounds from Emilia species. Phytochemistry, Oxford, 17 (3): 577-8, 1978.
BOHLMANN, F. & SUWITA,A. Über die inhaltsstoffe von Senecio abrotanifolius L. Chemische Berischte, Berlin, 109 (6): 2014-20, 1976.
BORGES, P.A.L. Isolamento de 1-hidróxi-4-oxo-2,5-ciaclohexadien-1-acetato de etila de Jacaranda puberula Cham. Porto Alegre, Universidade Federal do Rio Grande do Sul, Curso de Pós-graduação em Farmácia, 1980, 49f. Diss. mestr. farmácia.
CODE of federal regulations, Titulo 21, Superintendent of Documents, U.S. Government Printing Office, Washington, D.C., 1978, p.223-35, 746.
GERAN, R.I. et alii. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemoterapy Reports; Part 3, Washington D.C., 3 (2): 1-103, 1972.
GOODWIN, S. & WITKOP, B. Quinol intermediates in the oxidation of phenols and their rearrangements. Journal of the American Chemical Society, Washington D.C., 79(1): 179-85, 1957.
HEGNAUER, R. Chemotaxonomic der pflanzen. Basel, Birkhäuser, 1964, v.3, p. 276.
JOSHI,K.C. et aZii. Components of the stem barks of Phyllarthron comorense and Jacaranda mimosaefolia and the roots of Desmodium pulchellum. Indian Journal of Chemistry, B, New Delhi, 13 (8): 869-70, 1975. Apud Chemical Abstracts, Columbus, 83 (17):144550r, 1975.
MINGOLA, Q. Química farmacêutica, São Paulo, Edgard Blücher, 1967. p. 677.
NATIONAL CANCER INSTITUTE. Drug Evaluation Branch. Screening date summary interpretation and outline of current screen; instruction 14. Bethesda, 1978-9. p. 1-28.
OGURA, M. et alii. Potential anticancer agents. III. Jacaranone, a novel phytoquinoid from Jacaranda caucana. Lloydia. Cincinnati, 39 (4): 255-7, 1976.
______________. Potential anticancer agents. IV. Constituints of Jacaranda caucana Pittier (Bignoniaceae). Lloydia, Cincinnati, 40 (2): 157-68, 1977.
______________. Jacoumaric acid, a new triterpene ester from Jacaranda caucana. Phytochemistry, Oxford, 16 (2): 286-7, 1977.
PARIS, R. R. & MOYSE, H. Precis de matière medicale. Paris, Masson, 197. V. 1, p. 78.
REITZ, R. et alii. Projeto madeira de Santa Catarina. Itajaí, Sudesul, 1978. P. 66-72.
SIEGEL, A. & KECKEIS, H. Über eine modifizierte form der reformatski-reaktion. Monatshefte fuer Chemie, Wien, 84: 910-8, 1953.
SILVA, M.C.M. da et alii, 1-hidróxi-4-oxo-2,5-ciclohexadieno-1-acetato de etila em Jacaranda mimosaefolia D. Don - Bignoniaceae. Ciência e Natura, Santa Maria, (3): 41-44, 1981.
SUBRAMANIAN, S.S. et alii, Flavonoids of eight bignoniaceus plants. Phytochemistry, Oxford, 11 (4): 1499, Apr. 1972.
ZIRVI, K.A. & AMIR, F. Chemical investigation of Jacaranda acutifolia. Pakistan Journal of Scientific and Industrial Research, Karachi, 16 (5): 178, 1973. APud Chemical: Abstracts, Columbus, 81 (3): 10958e, 1974.
Downloads
Published
How to Cite
Issue
Section
License
To access the DECLARATION AND TRANSFER OF COPYRIGHT AUTHOR’S DECLARATION AND COPYRIGHT LICENSE click here.
Ethical Guidelines for Journal Publication
The Ciência e Natura journal is committed to ensuring ethics in publication and quality of articles.
Conformance to standards of ethical behavior is therefore expected of all parties involved: Authors, Editors, Reviewers, and the Publisher.
In particular,
Authors: Authors should present an objective discussion of the significance of research work as well as sufficient detail and references to permit others to replicate the experiments. Fraudulent or knowingly inaccurate statements constitute unethical behavior and are unacceptable. Review Articles should also be objective, comprehensive, and accurate accounts of the state of the art. The Authors should ensure that their work is entirely original works, and if the work and/or words of others have been used, this has been appropriately acknowledged. Plagiarism in all its forms constitutes unethical publishing behavior and is unacceptable. Submitting the same manuscript to more than one journal concurrently constitutes unethical publishing behavior and is unacceptable. Authors should not submit articles describing essentially the same research to more than one journal. The corresponding Author should ensure that there is a full consensus of all Co-authors in approving the final version of the paper and its submission for publication.
Editors: Editors should evaluate manuscripts exclusively on the basis of their academic merit. An Editor must not use unpublished information in the editor's own research without the express written consent of the Author. Editors should take reasonable responsive measures when ethical complaints have been presented concerning a submitted manuscript or published paper.
Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.