Phytochemical, cytotoxic, antileishmania and antimicrobial potentials of Rhodes grass (Chloris gayana Kunth)

Authors

DOI:

https://doi.org/10.5902/2179460X72377

Keywords:

Antimicrobial, Poaceae, Antibacterial resistance, Antileishmania, Phytochemistry

Abstract

The present study aimed to analyze the cytotoxic and antimicrobial activity of the plant Chloris gayana Kunth (Poaceae) proceeding from the ethanol extract, taking into consideration its major secondary metabolites, such as alkaloids, triterpenes, steroids, flavonoids, and tannins. The ethanol extract showed no antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida krusei. However, the ethanol extract was able to potentiate the activity of amikacin against a strain of S. aureus MRSA (methicillin resistant S. aureus), suggesting a possible application of the extract itself or its isolated phytochemicals, as adjuvants of amikacin in the treatment of infections caused by MRSA strains resistant to this antibiotic. Potential antileishmanial activity was observed, but further research on the isolated action of these metabolites is needed.

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Author Biographies

Maria José Cândido de Oliveira, Universidade Federal de Campina Grande

Pharmacist by Universidade Federal de Campina Grande (UFCG). During my undergraduation, I have worked in research projects on Chemistry of Natural Products, focused on the phytochemical prospection of the species Chloris gayana Kunth (Poaceae).

Cíntia Régis da Silva Reis, Federal University of Piauí

Undergraduate student in Pharmacy at Universidade Federal do Piauí (UFPI). Collaboration in research projects on Pharmacology of Natural Products.

Paulo Sousa Lima Junior, Federal University of Piauí

Undergraduate student in Pharmacy at Universidade Federal do Piauí (UFPI). Experience in ​Organic Chemistry and ​​Microbiology of Natural Products, working on the modulation of antimicrobial substances against some microorganisms.

Jonas Nascimento de Sousa, Federal University of Piauí

Pharmacist, Master’s degree student at Universidade Federal do Piauí (UFPI). Experience in Microbiology of Natural Products, with focus on Staphylococcus aureus, Phyllanthus amarus, bacterial resistance, phyllanthin and fluoroquinolones.

Enoque Pereira Costa Sobrinho-Júnior, Federal University of Piauí

Veterinarian, Master’s degree in Biological Sciences at Northern Arizona University (NAU). During my undergraduation, I have worked in research projects on antileishmanial effects of natural products, collaborating with some research projects.

Michel Muálem de Moraes Alves, Federal University of Piauí

Veterinarian, Ph.D. in Tropical Zootechnics, Assistant Professor at Universidade Federal do Piauí (UFPI). Working on bioprospection of natural and synthetic products, natural polymers-based and semi-solid formulations with antileishmania activity.

Fernando Aécio de Amorim Carvalho, Federal University of Piauí

Veterinarian, Ph.D. in Biochemistry and Immunology, Full Professor at Universidade Federal do Piauí (UFPI). Experience in Biochemistry and Applied Immunology, focused on immunization, and treatment of visceral and cutaneous leishmaniasis.

Antonia Maria das Graças Lopes Citó, Federal University of Piauí

Pharmacist, Ph.D. in Organic Chemistry, Full Professor at Universidade Federal do Piauí (UFPI). Works in the area of Chemistry, with emphasis on Organic Synthesis and Chemistry of Natural Products, studying chemical composition and biological activity.

Carlos Alberto Garcia Santos, Universidade Federal de Campina Grande

Biologist, Ph.D. in Biological Sciences (Botany), Associate Professor at Universidade Federal de Campina Grande (UFCG). Currently developing the projects: “Flora do Curmataú Paraibano” and “Restoration of the Olho D'Água da Bica Forest Garden”. Curator of the Herbarium of the UFCG.

Humberto Medeiros Barreto, Federal University of Piauí

Biologist, Ph.D. in Biotechnology, Associate Professor at Universidade Federal do Piauí (UFPI). Experience in the following topics: natural and synthetic products as antimicrobial agents, modulators of antibiotic resistance and as photosensitizing agents.

Danielly Albuquerque da Costa, Federal University of Paraíba

Pharmacist, Ph.D. in Natural and Synthetic Bioactive Products, Associate Professor currently at Universidade Federal da Paraíba (UFPB), and formerly at Universidade Federal de Campina Grande (UFCG). Developing research and extension activities in the areas of Phytochemistry and Integrative Therapies.

Daniel Dias Rufino Arcanjo, Federal University of Piauí

PhD in Biotechnology (2016) from the Northeast Biotechnology Network (RENORBIO/UFPI), with Doctoral Internship (PDSE-CAPES) at Aarhus University, Denmark (2015). He was a Visiting Researcher at the Department of Biomedicine at Aarhus University, Denmark (2017) under the supervision of Prof. Ulf Simonsen. Pharmacist (2006) and Master in Pharmacology (2009) from the Federal University of Piauí (UFPI). He currently holds the positions of Adjunct Professor in the Department of Biophysics and Physiology at CCS/UFPI and Local Coordinator of the Postgraduate Program in Biotechnology-RENORBIO/UFPI (2019-Current). Permanent Professor of PPGs in Pharmaceutical Sciences-PPGCF (CCS/UFPI) and Biotechnology-RENORBIO/UFPI. He works as Associate Editor of the journal JOURNAL OF GLOBAL INNOVATION (JGI) (ISSN 2184-7738) and Reviewer for several periodicals with international circulation. He has experience in the areas of Pharmacology and Pre-clinical Toxicology of Natural and Synthetic Products, with an emphasis on prospecting bioactive molecules with action on the Cardiovascular System.

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2023-11-20

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Oliveira, M. J. C. de, Reis, C. R. da S., Lima Junior, P. S., Sousa, J. N. de, Costa Sobrinho-Júnior, E. P., Alves, M. M. de M., Carvalho, F. A. de A., Citó, A. M. das G. L., Santos, C. A. G., Barreto, H. M., Costa, D. A. da, & Arcanjo, D. D. R. (2023). Phytochemical, cytotoxic, antileishmania and antimicrobial potentials of Rhodes grass (Chloris gayana Kunth). Ciência E Natura, 45, e32. https://doi.org/10.5902/2179460X72377

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Vol. 45 (2023): Continuous Publication

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Chemistry

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Reviewers: Any manuscripts received for review must be treated as confidential documents. Privileged information or ideas obtained through peer review must be kept confidential and not used for personal advantage. Reviewers should be conducted objectively, and observations should be formulated clearly with supporting arguments, so that Authors can use them for improving the paper. Any selected Reviewer who feels unqualified to review the research reported in a manuscript or knows that its prompt review will be impossible should notify the Editor and excuse himself from the review process. Reviewers should not consider manuscripts in which they have conflicts of interest resulting from competitive, collaborative, or other relationships or connections with any of the authors, companies, or institutions connected to the papers.

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