Ketamine in the treatment of cocaine use disorders

Authors

DOI:

https://doi.org/10.5902/2179460X44077

Keywords:

Cocaine treatment, Ketamine, Motivation, URICA, EAS-40

Abstract

Introduction: ketamine is a dissociative anesthetic and, recently, its antidepressant properties has been described. Besides, its safety has been proven in the treatment of Stimulant Use Disorders. Objective: to evaluate the use of ketamine in the treatment of Stimulant Use Disorders (specially cocaine and its byproducts). Methods: patient's motivation for change was measured by URICA scale and psychiatric symptoms by EAS-40 score, both before and after the intervention. Results: it was verified, after the comparison between the Readiness Score means, an increase in the motivation for change after ketamine’s single administration, when compared to the moments before and after the intervention. Analyzing the Global Severity Index before and after ketamine administration, by EAS-40 score, we noticed a slight reduction of the psychiatric symptoms before and after the intervention. Conclusion: it was proven that ketamine's single administration led to a quick and lasting improvement on the user's motivation without worsening the mental health status.

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Author Biographies

Ronaldo Cascelli Schelb Scalla Pereira, Universidade Federal de Viçosa, Viçosa, MG

Mestre em Ciências da Saúde, programa de Pós-graduação em Ciências da Saúde, Departamento de Medicina e Enfermagem - DEM pela Universidade Federal de Viçosa. 

Emanuelle Emília Ferreira Parreiras, Universidade Federal de Viçosa, Viçosa, MG

Mestre em Ciências da Saúde, programa de Pós-graduação em Ciências da Saúde, Departamento de Medicina e Enfermagem - DEM, Universidade Federal de Viçosa. 

Davi Cascelli Schelb Scalla Pereira, Academia Brasileira de Neurologia, São Paulo, SP

Especialista em Neurologia, Academia Brasileira de Neurologia.

João Eduardo Schelb Scalla Pere Cascelli, Sociedade Brasileira de Nefrologia - SBN.

Possui graduação em Medicina pela Universidade Federal de Juiz de Fora. Especialista em Nefrologista, Sociedade Brasileira de Nefrologia - SBN.

Thaila Vidal de Oliveira, Sociedade Brasileira de Endocrinologia e Metabologia, Rio de Janeiro, RJ

Possui graduação em Medicina pela Faculdade de Ciências Médicas e da Saúde de Juiz de Fora. Residência médica em clínica médica e endocrinologia. Especialista em Endocrinologia e Metabologia, Hospital e Maternidade Therezinha de Jesus.

Leonardo de Paula Junqueira, Associação Brasileira De Psiquiatria, Casa de Caridade de Muriaé Hospital São Paulo, Muriaé, MG

Possui graduação em Medicina pela Universidade Iguaçu. Atualmente é psiquiatra do Hospital São Paulo. Especialista em Psiquiatria, Associação Brasileira De Psiquiatria.

Valdinei Godinho Pereira, Centro de Capacitação Profissional, Casa de Caridade de Muriaé Hospital São Paulo, Muriaé, MG

Técnico em Enfermagem, Centro de Capacitação Profissional - CECAP

Marcelo Barcellos da Rosa, Departamento de Química da Universidade Federal de Santa Maria, Santa Maria, RS

Professor do Departamento de Química da Universidade Federal de Santa Maria.

Tiago Ricardo Moreira, Departamento de Enfermagem e Medicina, Universidade Federal de Viçosa, Viçosa, MG

Professor da Universidade Federal de Viçosa. Departamento de Enfermagem e Medicina.

Marilane de Oliveira Fani Amaro, Departamento de Enfermagem e Medicina, Universidade Federal de Viçosa, Viçosa, MG

Professora da Universidade Federal de Viçosa. Departamento de Enfermagem e Medicina.

Bruno David Henriques, Departamento de Enfermagem e Medicina, Universidade Federal de Viçosa, Viçosa, MG

Professora da Universidade Federal de Viçosa. Departamento de Enfermagem e Medicina.

Camilo Amaro de Carvalho, Departamento de Enfermagem e Medicina, Universidade Federal de Viçosa, Viçosa, MG

Professor da Universidade Federal de Viçosa. Departamento de Enfermagem e Medicina.

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Published

2021-05-18 — Updated on 2022-04-06

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How to Cite

Pereira, R. C. S. S., Parreiras, E. E. F., Pereira, D. C. S. S., Cascelli, J. E. S. S. P., Oliveira, T. V. de, Junqueira, L. de P., Pereira, V. G., Rosa, M. B. da, Moreira, T. R., Amaro, M. de O. F., Henriques, B. D., & Carvalho, C. A. de. (2022). Ketamine in the treatment of cocaine use disorders. Ciência E Natura, 43, e22. https://doi.org/10.5902/2179460X44077 (Original work published May 18, 2021)

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