Redox signaling and inflammatory statuses of farmers exposed to agrochemicals
Keywords:Farmers, Intoxication, Oxidative stress
Physiological changes take place in the human body upon exposure to pesticides. These changes may be followed by oxidative stress, which is caused by imbalance between the antioxidant defense system and reactive oxygen species (ROS) generation. Pesticides can cause inflammatory changes, which alter the structure of some cytokines essential for the functioning of the human body. Therefore, the aim of the present study is to assess the oxidative and inflammatory status of farmers exposed to pesticides. Blood samples from 50 exposed farmers and 50 non-exposed individuals (Control Group - CG) were collected. Oxidative stress and inflammatory marker levels were assessed. The assessed farmers reported higher levels than the CG, as follows: TBARS (p <0.0001), IL-6 (p = 0.03700), IL-8 (p = 0.0011) and IL-10 (p = 0.0011) (p <0.001), GST (p <0.001), GST (p <0.001), GST (p <0.001) 0001) and BChE (p <0.0001). Farmers presented high oxidative stress, low antioxidant levels and inflammatory changes.
AGÊNCIA NACIONAL DE VIGILÂNCIA SANITÁRIA (ANVISA). Disponível em: http://portal.anvisa.gov.br/agrotóxicos. Acesso em: 11 set. 2017.
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