Structural characteristics and biotechnological applications of frutalin: lectin extracted from Artocarpus incisa

Authors

DOI:

https://doi.org/10.5902/2179460X30905

Keywords:

Artocarpus incisa, Frutalin, Toxicity

Abstract

Frutalin is a lectin extracted from the seeds of Artocarpus incisa, which belongs to the Moreacae family. This family consists of approximately 75 genera and 1,550 tropical species that commonly found in pan-tropical regions. Frutalin has attracted the attention of researchers due to its ability to recognize carbohydrates in cell membranes with modifications in the glycosylation pattern. Therefore, frutalin presents a striking potential to be used as biomarker of cancer cells. Despite having a great biotechnological potential, research involving this lectin is still limited. Thus, the aim of this review is to discuss the structural and functional characteristics of frutalin, properties, the mechanisms of action, as well as the biotechnological applications of this lectin.

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Author Biographies

Bianca Régia Silva, Núcleo de Biotecnologia de Sobral, Universidade Federal do Ceará, Sobral, Ceará, Brasil.

Possui graduação em Ciências Biológicas, pela Universidade Estadual Vale do Acaraú - UVA (2016). Mestranda em Biotecnologia pelo Programa de Pós-graduação em Biotecnologia da Universidade Federal do Ceará - UFC, campus Sobral.

Franscisco Léo Nascimento de Aguiar, Laboratório de Manipulação de Oócitos e Folículos Ovarianos Pré-antrais - LAMOFOPA, Universidade Estadual do Ceará, Fortaleza, Ceará, Brasil.

Possui graduação em Medicina Veterinária pela Universidade Estadual do Ceará (2003 - 2008), mestrado em Ciências Veterinárias pela Universidade Estadual do Ceará (2009 - 2010) e doutorado em Ciências Veterinárias pela Universidade Estadual do Ceará (2012 - 2016), vinculado ao Laboratório de Manipulação de Oócitos inclusos em Folículos Ovarianos Pré-Antrais - LAMOFOPA. Realizou Doutorado Sanduíche na Southern Illinois University - Carbondale, IL com realização de experimentos em parceria com a Mississipi State University (MSU). Como aluno de Iniciação Científica, realizou estágio no Laboratório de Fisiofarmacologia Cardio-Renal e foi monitor da disciplina de Terapêutica Veterinária. Durante estágio supervisionado obrigatório, realizou pesquisa com Leishmaniose Visceral (a campo) e Tegumentar (in vivo). Durante Mestrado, realizou pesquisa acadêmica no estudo de extratos de plantas com atividade antifúngica, possuindo experiência em Micologia Médica Veterinária. Durante doutorado, realizou pesquisa no cultivo in vitro de folículos pré-antrais equinos, possuindo experiência na área de reprodução com enfoque em equínos no cultivo in vitro de folículos pré-antrais e criopreservação de tecido ovariano.

José Roberto Viana Silva, Núcleo de Biotecnologia de Sobral, Universidade Federal do Ceará, Sobral, Ceará, Brasil.

Possui graduação em Medicina Veterinária pela Universidade Estadual do Ceará (1999), mestrado em Ciências Veterinárias pela Universidade Estadual do Ceará (2000), doutorado em Ciências Veterinárias pela Universidade Estadual do Ceará (2004) e em Reprodução Animal pela University of Utrecht (2005). Atualmente é professor associado da Universidade Federal do Ceará e está vinculado vinculado aos programas de pós-graduação em Biotecnologia da RENORBIO e também da UFC (PPGB), onde atuou com coordenador no ano de 2011. É consultor de vários periódicos internacionais ( e nacionais e tem experiência na área de reprodução animal, com ênfase em biologia celular, fisiologia e embriologia. Atua principalmente nos seguintes temas: cultivo in vitro de folículos ovarianos, maturação oocitária e biologia molecular.

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Published

2018-03-27

How to Cite

Silva, B. R., Aguiar, F. L. N. de, & Silva, J. R. V. (2018). Structural characteristics and biotechnological applications of frutalin: lectin extracted from Artocarpus incisa. Ciência E Natura, 40, e46. https://doi.org/10.5902/2179460X30905

Issue

CIÊNCIA E NATURA, V. 40, 2018

Section

Chemistry

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