Selênio: funções biológicas e efeitos tóxicos

Authors

  • Marcelo Farina Centro de Ciências da Saúde, Universidade Regional Integrada do Alto Uruguai e das Missões, Erechim, RS.

DOI:

https://doi.org/10.5902/2179460X27112

Abstract

Many studies have indicated the toxicological role of organic and inorganic species of selenium, inducing the appearance of a large variety of process that cause the injury of animals and humans tissues.
However, its well known that selenium is an essential trace element for man and its deficiency is the major cause of some mammalian pathologies like cardiac and muscular diseases. This review approach the chemical characteristics of selenium, relating them with their physiologic and toxicologic effects. Consideration about the absorption, metabolism and excretion of species of selenium are also showed.

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References

AMOR, A. J. & PRINGLE, P. A review of selenium as an industrial hazard.

BulI. Hyg. 20: 239 (1945).

ANUNDI, 1.; STAHL, A.; HOGBERG, J. Effects of selenite on O2 consumption, glutathione oxidation and NADPH levels in isolated hepatocytes and the role of redox changes in selenite toxicity. Chem. Biol. Interact. 50: 277-288 (1984).

BARBOSA, N. B. V.; ROCHA, J. B. T.; ZENI, G.; EMANUELLI, T.; BEQUE, M. C.; BRAGA, A. L. Effect of organic forms of selenium on 0-aminolevulinate dehydratase from liver, kidney, and brain of adult rats. Toxicol. Appl. Pharmacol. 149: 243-253 (1998).

BEHNE, D.; KYRIAKOPOULOS, A. Identification of type I iodothyronine 5'-deiodinase as a selenoenzyme. Biochem. Biophys. Res. Commun 173: 1143-1149 (1990).

BOOP, B. A.; SONDERS, R. C.; KESTERSON, J. W. Metabolic fate of selected selenium compounds in laboratory animals and mano Drug. Metabolism. Review. 13 (2): 271-318 (1982).

BROWN, D. G.; BURK, R F.; SEELY, R J.; KIKER, K. W. Effects of dietary selenium on the gastrointestinal absorption of (75Se)2 in rat. Int. J. Vitam. Nutr. Res. 42: 588-591 (1972).

BUCHAN, R F. Industrial selenosis. Occupational Medicine. 3: 439 (1947).

BUEL, D. N. Potential hazards of selenium as a chemopreventive agent. Seminars in Oncology. 10: 311-321 (1983).

CALDWELL, K. A. & TAPPEL, A. L. Acceleration of sulphydryl oxidations by selenocystine. Arch. Biochem. Biophys. 112: 196-200 (1965).

CALVERT, C. C.; NESHEIM, M. C.; SCOTT, M. L. Effectiveness of selenium in prevention of nutritional muscular dystrophy in the chick. Proc. Soc. Exp. Biol. Med. 109: 16-18 (1962).

CARTER, R F. Acute selenium poisoning. The Medical Journal of Australia. 26: 525-527 (1966).

CAVALlERI, R R In Goodhart, R S.; Shils, M. E., eds: Modem nutrition in health and disease re" ed). Philadelphia: Lea & Febiger, 395pp. (1980).

CAVALlERI, R R; SCOTT K. G.; SAIRENJI, E. Selenite (75Se) as a tumor-Iocalizing agent in manoJ. Nucl. Med. 7: 197-208 (1966).

CERWENKA, E. A. & COOPER, W. C. Toxicology of selenium and tellurium compounds. Arch. Environ. Health. 3: 189-199 (1961).

CHEN, G. & ZIEGLER, D.M. Liver microsomes and flavin-containing monooxygenase catalyzed oxidation of organic selenium compounds. Arch. Biochem. Biophys 312: 566-572 (1994)

COWIE, D. B. & CHOEN, G. N. Biosynthesis by Escherichia coli of altered proteins containing selenium instead of sulfur. Biochim. Biophys. Acta. 26: 252-261 (1957).

DIKSON, R C. & TAPPEL, A. L. Effects of selenocystine and selenomethionine on activation of sulphydryl enzimes. Arch. Biochem. Biophys. 131: 100-110 (1969).

DISKIN, C. J.; TOMASSO, C. L.; ALPER, J. C.; GLASER, M. L.; FIEGEL, S. E. Long-term selenium exposure. Arch. Intern. Med. 139: 824-826 (1979).

EGGERT, R G.; PATTERSON, E.; AKERS, W. T.; STOKSTAD, E. L. R. The role of vitamin E and selenium in the nutrition of the pig. J. Anim. Sei. 16: 1037 (1957).

FLOHE, L.; GUNZLER, W. A; SCHOCK, H.H. Glutathione peroxidase: A selenium enzyme. FEBS Lett 32: 132-134 (1973).

FRANKE, K. W. A new toxicant occurring naturally in certain samples of plant foodstuffs. I. Results obtained in preliminary feeding trials. J. Nutr. 8: 597-608 (1934).

GANTHER, H. E. Selenotrisulfides. Formation by reaction of thiols with selenious acid. Biochemistry. 10: 4089-4098 (1971).

GANTHER, H.E. Selenotrisulfides. Formation by reaction of thiols with selenious acid. Biochemistry. 7: 2898-2905 (1968).

GARBERG, P.; STAHL, A; WARHOLM, M.; HOGBERG, J. Studies of the role of DNA fragmentation in selenium toxicity. Biochem. Pharmacol. 37: 3401-3406 (1988).

GOEGER, D.E. & GANTHER, H. E. Oxidation of dimethyl selenide to dimethyl selenoxido by microssomes from rat liver and flavingcontaining monooxygenase from big liver. Arch. Biochem. Biophys. 310: 448-451 (1994).

GOLDMAN, I. & KANTROWITZ, N. E. Cardiomyiopathy associated with selenium deficiency. N. Engl. J. Med. 305: 701 (1981).

GÜNZLER, W. A; STEFFENS, G. J.; GROSSMANN, A; KIM, S. M.; OTTING, F.; WENDEL, A, FLOHE, L. The amino-acid sequence of bovine glutathiione peroxidase. Hoppe seyelers Z Physiol Chem. 365(2): 195-212 (1984).

HAMILTON, A. Industrial poisons in the United States. New York, Macmillan Co. (1925).

HARTLEY, W. J. & GRANT, A B. A review of selenium-responsive diseases of New Zealand livestock. Fed. Proc. 20: 679-688 (1961).

HELZLSOUER, K.; JACOBS, R; MORRIS, S. Acute selenium intoxication in the United States. Fed. Proc. Am. Soe. Exp. Biol. 44: 1670 (1985).

HOFFMAN, J. L. & McCONNELL, K. P. Periodate-oxidized adenosine inhibits the formation of dimethylselenide and trimethylselenium ion in mice treated with selenite. Areh. Biochem. Biophys. 254(2): 534-540 (1986).

HOJO, Y. Subject groups high and low in urinary selenium levels, workers exposed to heavy metals and patients with cancer and epilepsy. BulI. Environ. Contam. Toxicol. 26: 466-471 (1981).

HOLNES, D. L.; TARASCHUCK, I. G.; NETHERCOTT, J. R. Health status of cooper refiney workers with specific reference to selenium exposuro. Arch. Environ. Health. 44: 291-297 (1989).

HOPKINS, L. L.; POPE, A. L.; BAUMANN, C. A. Distribution of microgram quantities of selenium in tissues of the rat, and effects of previous selenium intake. J. Nutr. 88: 61-65 (1966).

HSIEH, H. S. & GANTHER, H. E. Effects of stock or purified diet on rat liver enzymes involved in the synthesis of dimethyl selenide. J. Nutr. 106(11): 1577-1582 (1976).

HUNT, D.; LANE, H.; BEESINGER, D.; GALLGHER, K.; ROWLANDS, B. J.; JOHNSTON, D. Selenium and glutathione peroxidase levels in hospitalized burn patients. Fed. Proc. 42; 927 (1983).

KICE, J. L. & LEE, W. S. Oxidation-reduction reactions of organoselenium compounds. 1. Mechanism of the reaction between seleninic acids and thiols. J. Am. Chem. Soe. 100(16): 5092-5102 (1977).

KITAHARA, J.; SEKO, Y.; IMURA, N. Possible involvement of active oxygen species in selenite toxicity in isolated rat hepatocytes. Arch. Toxicol. 67: 497-501 (1993).

KLAYMAN, D. L. IN: KLAYMAN, D. L.; GANTHER, W. H. (Eds.), Organic Selenium Compounds: Their Chemistry and Biology, John Wiley and sons, New York, 68-157pp (1973).

KUIKKA, J. & NORDMAN, E. Measurement of (75Se) sodium selenite in the human body. Int. J. Nucl. Med. Biol. 5: 30-34 (1978).

LEAVANDER, O. A. & BECK, M. A. Interacting nutritional and infectious etiologis of Keshan disease. Insights from coxsackie virus B-induced myocarditis in mice deficient selenium or vitamin E. Biol. Trace Elem. Res. 56: 5-21 (1997).

LEVANDER, O. A. & BAUMANN, C. A. Selenium metabolism VI: Effects of arsenic on the excretion of selenium in bile. Toxicol. Appl. Pharmacol. 9: 106-115(1966).

LlNDER, M. C. Nutrition and metabolism of the trace elements. 7: 216-277 (1990).

MARTIN, J. L. & GERLACK, M. Selenium metabolism in animals. Ann N Y Acad Sci. 192-193 (1972).

MARTIN, J. L. IN: KLA YMAN, D. L.; GANTHER, W. H. (Eds.), Organic Selenium Compounds: Their Chemistry and Biology, John Wiley and sons, New York, 663-691pp. (1973).

MOZIER, N. M.; McCONNELL, K. P.; HOFFMAN, J. L. S-adenosyl-Lmethionine: thioether S-methyltransferase, a new enzyme in sulfur and selenium metabolism. J. Biol. Chem. 263: 4527-4531 (1988).

MUTH, O. H.; OLDFIELD, J. E.; REMMERT, L. F.; SCHUBERT, J. R. Effects of selenium and vitamin E on white muscle disease. Science. 198: 1090 (1958).

OKAMOTO, Y. & GÜNTHER, W. H. H. Organic selenium and tellurium chemistry. Annals of the New Yor!

OLDFIELD, J.E. The two faces of selenium. J. Nutr 117: 2002-2008 (1987).

PAINTER, E. P & FRANKE, K. W. Selenium in proteins from toxic foodstuff. 11. The effect of acid hydrolysis. Cereal Chem. 13: 172-179 (1936).

PAINTER, E. P. The chemistry and toxicity of selenium compounds which special reference to the selenium problem. Chem. Rev 28: 179-213 (1941).

ROTRUCK, J.T.; POPE, A.L.; GANTHER, H.E.; SWANSON, A. B.; HAFEMAN, D. G.; HOESTRA, W. G. Selenium: Biochemical role as a component of glutatione peroxidase. Science. 179: 558-560 (1973).

SAlTO, Y.; HASHIMOTO, T.; SASAKI, M.; HANAOKA, S.; SUGAI, K. Effect of selenium deficiency on cardiac function of individuals with severe disabilities under long-term tube feeding. Devel. Med. & Child Neurol. 40: 743-748 (1998).

SCHONEICH, F. C.; NARAYANASWAMI, V.; ASMUS, K. D.; SIES, H. Reactitity ebselen and related selenorganic compounds with 1,2-dichloro ethane radical cations and halogenated peroxyl radicals. Arch. Biochem. Biophys. 288: 18-25 (1990).

SCHWARZ, K. & FOLTZ, C. M. Selenium as an integral part of factor 3 against dietary necrotic liver degeneration. J. Am. Chem. Soe. 79: 3292-3292 (1957).

SCHWARZ, K. & PORTER, A. L. Some regularites in the structurefunction relationship of organoselenium compounds effective against dietary liver necrosis. Annals of the New York Academy of Sciences. 192: 200-214 (1972).

SEKO, Y.; SAlTO, Y.; KITAHARA, J.; IMURA, N. Active oxygen generation by the reaction of selenite with reduced gluathione in vitro. In: Wendel, A (ed). Selenium in biology and medicine. Springer, Berlin Heldeiberg. New York. pp:70-73 (1989).

SHRIFT, A. & VIRUPAKSHA, T. K. Seleno-amino acids in selenium containing accumulator plant. Biochim. Biophys. Acta. 100: 65-75 (1965).

SMITH, M. I.; FRANKE, K. W.; WESTFALL, B. B. The selenium problem in relation to public health. Public. Health. Rep. 51; 1496 (1936).

SPALLHOLZ, J. E. On the nature of selenium toxicity and carcinostatic activity. Free Radical Biology & Medicine. 17: 45-64 (1993).

STADTMAN, T. C. Biosynthesis and function of selenocysteine-containing enzymes. J. Biol. Chem. 266: 16257-16260 (1991).

STADTMAN, T. C. Selenium-dependent enzymes. Annu Rev Biochem. 49: 93-110 (1980).

SUNDE, R. A. & EVENSON, J. K. Serine incorporation into the selenocysteine moiety of glutathione peroxidase. J. Biol. Chem. 262(2): 933-937 (1987).

THOMSON, C. D. & STEWART, R. D. H. Metabolic studies of (75Se) selenomethionine and (75Se) selenite in the rat. Sr. J. Nutr. 30: 139-147 (1973).

THOMSON, C. D. & STEWART, R. D. H. The metabolism of (75Se) selenite in young woman. Sr. J. Nutr. 32: 47-57 (1974).

TRELEASE, S. F.; DISOMMA, A. A.; JACOSS, A.L. Seleno-amino acids

found in Astragalus bisulcatus. Science. 132: 618 (1960).

TSEN, C.C. & TAPPEL, A. L. Catalytic oxidation of glutathione and other sulphydril compounds biselenite. J. Biol. Chem 233: 1230-1232 (1958).

URSINI, F. & BINDOLl, A. The role of selenium peroxidases in the protection against oxidative damage of membranes. Chemistry and Physics of lipids. 44: 255-276 (1987).

URSINI, F.; MAORINO, M.; VALENTE, M.; FERRI, K.; GREGOLlN, C. Purification of pig liver of a protein which protects lipossomes and biomembranes from peroxidative degradation and exhibits glutathione peroxidase activity on phosphatidylcholine hydroperoxidase. Biochem. Siophys. Acta. 710: 197-211 (1982).

VALENTINE, J. L.; KANG, H. K.; SPIVEY, G. H. Selenium levels in human blood, urine and hair in response to exposure via drinking water. Environ. Res. 17: 347-355 (1978).

WHANGER, P. D.; PEDERSEN, N. D.; HATFIELD, J.; WESWING, P. H. Absortion of selenite and selenomethionine from ligated digestive tract segments in rats. Proc. SocoExp. Biol. Med. 153: 295-297 (1976).

WILBER, C. G. Toxicology of selenium: A review. Clinical. toxicology. 17 (2): 171-230 (1980).

XU, G. L.; WANG, S. C.; GU, B. a.; YANG, Y. x.; SONG, H. B.; XUC, W. L.; LlANG, W. s.; ZHANG, P. Y. Further investigation on the role of selenium deficiency in the etiology and pathogenesis of Keshan disease. Biomed. Environ. Sci. 10: 316-326 (1997).

YAN, L. & SPALLHOLZ, J. E. Free radicals generation by selenium compounds. Fase B. J. 5: 581 (1991).

YANG G.; WARG, S.; ZHOU, R. Endemic selenium intoxication of humans. Am. J. Clin. Nutr. 37: 872-881 (1983).

YANG, G. a. Keshan disease: an endemic selenium-related deficiency disease. In: Trace Elements in Nutrition of Children. R. K. Chandra, Ed. New York, Raven Press, pp. 273-289 (1985).

YANG, G. Research on selenium-related problems in human health in China. In: Selenium in Biology and Medicine (Combs, G. F.; Spallholz, J. E.; Levander, O. A.; Oldfield, J. E., eds.), vol A, 9-32, Van Nostrand Reinhold, New York (1987).

YASUDA, K.; WATANABE, H.; YAMAZAKI, S.; TODA, S. Gluthatione peroxidase activity of D, L-selenocystine and selenocystamine. Biochem. Biophys. Res. Commun. 98: 243-249 (1980).

YOUNG, V. R.; NAHAPETIAU, A; JONGHORBONI, M. Selenium bioavailability wilh reference 10 human nutrition. American. J. Clinical. Nutrition. 35: 1076-1088 (1982).

ZIEGLER, D. M.; GRAF, P.; POULSEN, L. L.; STAHL, W.; SIES, H. NADPH-dependent oxidation of reduced ebselen, 2- selenylbenzaniline, and 2(methylseleno)benzanilide catalized by pig flavin-containing monooxigenase. Chem. Res. Toxicol. 5: 163-166 (1991).

Published

2000-12-11

How to Cite

Farina, M. (2000). Selênio: funções biológicas e efeitos tóxicos. Ciência E Natura, 22(22), 59–82. https://doi.org/10.5902/2179460X27112