Degradation of the pharmaceuticals nimesulide and ibuprofen using photo-Fenton process: toxicity studies, kinetic modeling and use of artificial neural networks
DOI:
https://doi.org/10.5902/2236117031563Keywords:
Ibuprofen, Nimesulide, Photo-FentonAbstract
The growth of pollution in aquatic environments increases every day, causing compounds like pharmaceuticas to be detected in surface waters. Thus, tecniques such as advanced oxidation processes (AOP) have been used to degrade this compounds. In this work, the efficiency of AOP in the degradation of nimesulide and ibuprofen pharmaceuticals was evaluated through chromatographic analysis as well as organic matter through the levels of chemical oxygen demand (COD) and total organic carbon (TOC). It was verified that the photo-Fenton process presented the bests results, degrading 89.70% of nimesulide and 93.35% of ibuprofen. This same process managed to reduce COD by 91.60% and mineralize 90.04% of the TOC. The kinetic study showed a good linear fit (R2=0.993) for the clustered kinetic model, as well as a good fit to the mathematical model of artificial neural networks (ANNs), with a value of R2=1.000 for the MLP4-4-1 BFGS 4567 model. Finally, the toxicity of the solution after treatment was verified against the seeds of Lactuta sativa, Cichorium endívia, Ocimum basilicum and American Hard grain. It was found that the seeds that received the solution before treatment had a lower germination amount than the ones where the post AOP treatment solution was added. Then, the root growth was evaluated, in which a relative toxic effect was observed.
Downloads
References
ALHARBI, S. K.; KANG, J.; NGHIEM, L. D.; van de MERWE, J. P.; LEUSCH, F. D. L.; PRICE, W. E. Photolysis and UV/H2O2 of diclofenac, sulfamethozazole, carbamazepine and trimethoprim: Identification of their major degradation products by ESI-LC-MS and assessment of the toxicity of reaction mixtures. Process Safety and Environmental Protection, v. 112, p. 222-234, 2017.
APHA: AMERICAN PUBLIC HEALTH ASSOCIATION. Standard Methods For The Examination of Water and Wastewater. 22 ed. Washington: APHA, 2012.
ARAÚJO, K. S.; ANTONEL, R.; GAYDECZKA, B.; GRANATO, A. C.; MALPASS, G. R. P. Processos oxidativos avançados: uma revisão de fundamentos e aplicações no tratamento de águas residuais urbanas e efluentes industriais. Revista Ambiente & Água, v. 11, n. 2, p. 387-401, 2016.
BIALK-BIELINSKA, A.; KUMIRSKA, J.; BORECKA, M.; CABAN, M.; PASZKIEWICZ, M.; PAZDRO, K.; STEPNOWSKI, P. Selected analytical challenges in the determination of pharmaceuticals in drinking/marine waters and soil/sediment samples. Journal of Pharmaceutical and Biomedical Analysis, v. 121, p. 271-296, 2016.
BRASIL. AGÊNCIA NACIONAL DE VIGILÂNCIA SANITÁRIA (ANVISA). Resolução nº 899, de 29 de maio de 2003. Guia para validação de métodos analíticos e bioanalíticos. Diário Oficial da União, Brasília, 02 de junho de 2003.
BRASIL. CONSELHO NACIONAL DO MEIO AMBIENTE (CONAMA). Resolução nº 430, de 13 de maio de 2011. Dispõe sobre as condições e padrões de lançamento de efluentes. Diário Oficial da República Federativa do Brasil, Brasília, DF, v. 13, 2011.
BRITO, N. N. D.; SILVA, V. B. M. Processos oxidativos avançados e sua aplicação ambiental. Revista Eletrônica de Engenharia Civil, v. 1, n. 3, p. 36-47, 2012.
CANDIDO, J. P. Remoção de ibuprofeno por fotocatálise heterogênea e avaliação ecotoxicológica de possíveis subprodutos. 2016. 72 f. Dissertação (Mestrado em Meio Ambiente e Recursos Hídricos) - Universidade Federal de Itajubá, Itajubá, MG, 2016.
CARLSON, J. C.; STEFAN, M. I.; PARNIS, M. P.; METCALFE, C. D. Direct UV photolysis of selected pharmaceuticals, personal care products and endocrine disruptors in aqueous solution. Water Research, v. 84, p. 350-361, 2015.
CHRISTOU, A.; KARAOLIA, P.; EVROULA, H.; MICHAEL, C.; FATTA-KASSINOS, D. Long-term wastewater irrigation of vegetables in real agricultural systems: Concentration of pharmaceuticals in soil, uptake and bioaccumulation in tomato fruits and human health risk assessment. Water Research, v. 109, p. 24-34, 2017.
COSTA, F. M.; CAMPOS, J. C.; FONSECA, F. V.; BILA, D. M. Tratamento de lixiviados de aterros de resíduos sólidos utilizando processos Fenton e foto-Fenton Solar. Revista Ambiente & Água, v. 10, n. 1, p. 107-116, 2014.
EBELE, A. J.; ABDALLAH, M. A-E.; HARRAD, S. Pharmaceuticals and personal care products (PPCPs) in the freshwater aquatic environment. Emerging Contaminants, v. 3, n. 1, p. 1-16, 2017.
ERAGA, S. O.; ARHEWOH, M. I.; CHIBUOGWU, R. N.; IWUAGWU, R. N. A comparative UV−HPLC analysis of ten brands of ibuprofen tablets. Asian Pacific Journal of Tropical Biomedicine, v. 5, p. 880-884, 2015.
FUNAI, D. H.; DIDIER, F.; GIMÉNEZ, J.; ESPLUGAS, S.; MARCO, P.; JUNIOR, A. M. Photo-Fenton treatment of valproate under UVC, UVA and simulated solar radiation. Journal of Hazardous Materials, v. 323, p. 537-549, 2017.
GIRI, A. S.; GOLDER, A. K.; Decomposition of drug mixture in Fenton and photo-Fenton processes: Comparison to singly treatment, evolution of inorganic ions and toxicity assay. Chemosphere, v. 127, p. 254-261, 2015.
GRUBBS, F. E.; BECK, G. Extension of sample sizes and percentage points for significance tests of outlying observations. Technometrics, v. 14, n. 4, p. 847-854, 1972.
INSTITUTO NACIONAL DE METROLOGIA, NORMALIZAÇÃO E QUALIDADE INDUSTRIAL (INMETRO). DOQ-CGCRE-008: Orientações sobre Validação de Métodos Analíticos. Rev. 04, 2011. 20 p.
JALIL, A.; ATA, E.; MILAD, A.; VAHID, R. Statistical process control using optimized neural networks: A case study. ISA Transactions, v. 53, p. 1489-1499, 2014.
LIMA, D. R. S.; ALMEIDA, I. L. A.; PAULA, V. I. Degradação do corante Azul Reativo 5G elo processo oxidativo avançado UV/H2O2. E-Xacta, v. 9, n. 2, p. 101-109, 2016.
LUAN, M.; JING, G.; PIÃO, Y.; LIU, D.; JIN, L. Treatment of refractory organic pollutants in industrial wastewater by wet air oxidation. Arabian Journal of Chemistry, v. 10, p. 769-776, 2017.
MALTESE, A.; MAUGERI, F.; BUCOLO, C. Rapid determination of nimesulide in rabbit aqueous humor by liquid chromatography. Journal of Chromatography B, v. 804, p. 441-443, 2004.
MORAES, S.C.G.; ZAIDAN, L.E.M.C.; NAPOLEÃO, D. C.; CARVALHO, F. O.; MONTENEGRO, M. C. B.; SILVA, V. L. Implementing artificial neural networks modelling after the treatment of oil refinery effluents using advanced oxidation processes. Brazilian Journal of Petroleum and Gas, v. 10, n. 1, p. 23-32, 2016.
NAPOLEÃO, D. C.; ZAIDAN, L. E. M. C.; DIAZ, J. M. R.; SANTANA, R. M. R.; MONTENEGRO, M. C. B.; ARAUJO, A. N.; BENACHOUR, M.; SILVA, V. L. Use of the photo-Fenton process to discover the degradation of drugs present in water from the Wastewater Treatment Plants of the pharmaceutical industry. Afinidad, v. 75, p. 19-27, 2018.
NAPOLEÃO, D. C.; ZAIDAN, L. E. M. C.; SALGADO, J. B. A.; SALES, R. V.; SILVA, V. L. Degradação do contaminante emergente paracetamol empregando processos oxidativos avançados. Electronic Journal of Management, Education and Environmental Technology (REGET), v. 19, n. 3, p. 725-734, 2015.
NAPOLEÃO, D. C.; PINHEIRO, R. B.; ZAIDAN, L. E. M. C.; SALES, R. V. L.; BENACHOUR, M.; SILVA, V. L. Avaliação de toxicidade após submissão de efluente oriundo de ETE ao processo foto-Fenton like frente à semente de Lactuta sativa e ao grão Americano hard. In: Congresso Brasileiro de Engenharia Química, Out 2014. Florianópolis.
NAPOLEÃO, D. C.; BRANDÃO, Y. B.; BENACHOUR, M.; SILVA, V. L. Estudo do processo Foto-Fenton para tratamento de fármacos: otimização e modelagem cinética. Scientia Plena, v. 9, n. 9, p. 1-9, 2013.
NAVARRO, P.; GABALDÓN, J. A.; GÓMEZ-LÓPEZ, V. M. Degradation of an azo dye by a fast and innovative pulsed light/H2O2 advanced oxidation process. Dyes and Pigments, v. 136, n. 1, p. 887-892, 2017.
PEAKE, B. M.; BRAUND, R.; TONG, A. Y. C.; TREMBLAY, L. A. The Life-Cycle of Pharmaceuticals in the Environment. Cambridge: ELSEVIER, UK, 2016.
PERLATTI, B.; SILVA, M. F. G. F.; FERNANDES, J. B.; FORIM, M.R. Validation and application of HPLC–ESI-MS/MS method for the quantification of RBBR decolorization, a model for highly toxic molecules, using several fungi strains. Bioresource Technology, v. 124, n. 1, p. 37-44, 2012.
PINTO, L. H.; CARDOZO, G.; SOARES, J. C.; ERZINGER, G. S. Toxicidade ambiental de efluentes advindo de diferentes laboratórios de uma farmácia magistral. Revista Ambiente & Água, v. 11, n. 4, p. 819-832, 2016.
RAJABI, M.; MIRZA, B.; MAHANPOOR, K.; MIRJALILI, M.; NAJAFI, F.; MORADI, O.; SADEGH, H., SHAHRYARI-GHOSHEKANDI, R.; ASIF, M.; TYAGI, I.; AGARWAL, S.; GUPTA, V. K. Adsorption of malachite green from aqueous solution by carboxylate group functionalized multi-walled carbon nanotubes: Determination of equilibrium and kinetics parameters. Journal of Industrial and Engineering Chemistry, v. 34, p. 130-138, 2016.
ROCHA, O. R. S.; DUARTE, M. M. M. B.; DANTAS, R. F.; DUARTE, M. M. L.; SILVA, V. L. Oil sludge treatment by solar Tio2-photocatalysis to remove polycyclic aromatic hydrocarbons (PAH). Brazilian Journal of Petroleum and Gas, v. 8, n. 3, p. 89-96, 2014.
ROMERO, V.; GONZÁLEZ, O.; BAYARRI, B.; MARCO, P.; GIMÉNEZ, J.; ESPLUGAS, S. Degradation of Metoprolol by photo-Fenton: Comparison of different photoreactors performance. Chemical Engineering Journal, v. 283, p. 639-648, 2016.
SANTANA, R. M. R.; NASCIMENTO, G. E.; NAPOLEÃO, D. C.; DUARTE, M. M. M. B. Degradation and kinetic study of Reactive blue BF-5G and Remazol red RB 133% dyes using Fenton and photo-Fenton process. Electronic Journal of Management, Education and Environmental Technology (REGET), v. 31, n. 2, p. 104-118, 2017.
SANTOS-JUANES, L.; SÁNCHEZ, G. J. L.; LÓPEZ, C. J. L.; OLLER, I.; MALATO, I.; PÉREZ, S. J. A. Dissolved oxygen concentration: A key parameter in monitoring the photo-Fenton process. Applied Catalysis B: Environmental, v. 104, n. 3, p. 316-323, 2011.
SILVA, J. M.; MENDONÇA, P. P.; PARTATA, A. K. Anti-inflamatórios não-esteróides e suas propriedades gerais. Revista Científica do ITPAC, v. 7, n. 4, p. 1-15, 2014.
SKORONSKI, E.; FERRARI, A.; FERNANDES, M.; ELY, C.; JOÃO, J. J. Desempenho de um reator Fenton em escala industrial aplicado à remoção de fenóis em uma planta de recuperação de resíduos da indústria de papel e cellulose. Revista Ambiente & Água, v. 10, n. 4, p. 863-874, 2015.
SOUZA, R. R. Desenvolvimento e validação de metodologia analítica para determinação de desregulação endócrina resultante de atividades antrópicas nas águas do Rio Paraíba do Sul. 2011. 205 f. Dissertação (Mestrado em Tecnologia Nuclear – Materiais) - Universidade de São Paulo, São Paulo, SP, 2011.
STOYANOVA, K.; VINAROV, Z.; TCHOLAKOVA, S. Improving ibuprofen solubility by surfactant-facilitated self-assembly into mixed micelles. Journal of Drug Delivery Science and Technology, v. 36, n. 1, p. 208-215, 2016.
VALCÁRCEL, Y.; GONZÁLEZ, A. S.; RODRIGUEZ-GIL, J. L.; GIL, A.; CATALÁ, M. Detection of pharmaceutically active compounds in the rivers and tap water of the Madrid Region (Spain) and potential ecotoxicological risk. Chemosphere, v. 84, n. 1, p. 1336-1348, 2011.
YOUNG, B. J.; RIERA, N. I.; BEILY, M. E.; BRES, P. A.; CRESPO, D. C.; RONCO, A. E. Toxicity of the effluent from an anaerobic bioreactor treating cereal residues on Lactuca sativa. Ecotoxicology and Environmental Safety, v. 76, n. 2, p. 182-186, 2012.
ZAIDAN, L. E. M. C.; SILVA, A. M. R. B.; SALES, R. V.; SALGADO, J. B. A.; MORAES, S. C. G.; SOUZA, D. P.; GALVÃO, C. C.; RODRIGUEZ-DIAZ, J. M.; NAPOLEÃO, D. C.; BENACHOUR, B., SILVA, V. L. Optimization of phenol degradation and its derivatives using photo-Fenton and application industrial. Chemical and Process Engineering Research, v. 42, n. 1, p. 44-52, 2016.
ZANCHETA, P. G.; PENA, A.; GONÇALVES, R. F. Desenvolvimento e validação de método para quantificação simultânea de ofloxacina, norfloxacina e ciprofloxacina em urina humana. Engenharia Sanitária e Ambiental, v. 20, n. 2, p. 307-314, 2016.
ZHANG, Q.; CHUANG, K. T. Lumped kinetic model for catalytic wet oxidation of organic compounds in industrial wastewater. AIChE Journal, v. 45, n. 1, p. 145-150, 1999.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2018 Electronic Journal of Management, Education and Environmental Technology (REGET)
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
DECLARATION
