FUNCTIONAL AND NUTRACEUTICAL POTENTIAL OF PROTEINS FROM BOVINE MILK
DOI:
https://doi.org/10.5902/2236117012986Keywords:
bioactive peptides, functional foods, health, milk.Abstract
This review aims to characterize the effects of bioactive peptides (BAP) derived from bovine milk in the major body systems, including the cardiovascular, digestive, immune and nervous systems. To this end, we studied the main characteristics, ways of obtaining, composition and mechanisms of action of these protein fragments encoded in the primary region of milk proteins, as the peptide inhibitors of angiotensin- -converting enzyme (ACE) inhibitors, antithrombotics, opioids, immunomodulators, antimicrobials, and the caseinmacropeptides (CMP) and caseinophosphopeptides (CPP). Thus, with increasing demands by consumers and, consequently, the food industry, as the nutritional quality of foods and recent scientific and technological advances for the effects of PBA and production, have become excellent future prospects for this emerging market for functional dairy products.Downloads
References
AIHARA, K. et al. Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension. The Journal of the American College of Nutrition, v.24, n.4, p.257-265, 2005.
ALLESCHER, H.D. et al. Effect of opioid active therapeutics on the ascending reflex pathway in the rat ileum. Neuropeptides, v.34, n.3-4, p.181-186, 2000.
BELLAMY, W. et al. Identification of the bactericidal domain of lactoferrin. Biochimica et Biophysica Acta (BBA), v.1121, n.1-2, p.130-136, 1992.
BENKERROUM, N. Antimicrobial peptides generated from milk proteins: a survey and prospectus for application in the food industry. A review. International of Dairy Technology, v.63, n.3, p.320-338, 2010.
BEUCHER, S.et al. Effects of gastric digestive products from casein on CCK release by intestinal cells in rat. The Journal of Nutritional Biochemistry, v.5, n.12, p.578-584, 1994.
BODNAR, R.J. Endogenous opiates and behavior: 2008. Peptides, v.30, n.12, p.2432-2479, 2009.
BOUNOUS, G. et al. Whey protein as a food supplement in HIV-seropositive individuals. Clinical & Investigative Medicine, v.16, n.3, p.204-209, 1993.
BOUNOUS, G.; KONGSHAVN, P.; GOLD, P. The immunoenhancing property of dietary whey protein concentrate. Clinical & Investigative Medicine, v.11, n.14, p.271-278, 1998.
BOURTOURAULT, M. Effet des protéines du lactosérum bovin sur la multiplication de cellules cancéreuses humaines. Scholarly Societies Project, v.185, n.5, p.319-323, 1991.
CHMIEL, J.F. Anti-tumor effects of dietary whey protein and its value for head and neck cancer patients. In: International Dairy Federation: Proceedings of the 3rd International Whey Conference; 1997. Chicago. Brussels, Belgium: International Dairy Federation; 1998. p.310-314.
CLARE, D.A.; CATIGNANI, G.L.; SWAISGOOD, H.E. Biodefense properties of milk: The role of antimicrobial proteins and peptides. Current Pharmaceutical Design, v.9, n.16, p.1239-1255, 2003.
CLARE, D.A.; SWAISGOOD, H.E. Bioactive milk peptides: A prospectus. Journal of Dairy Science, v.83, n.6, p.1187-1195, 2000.
COLES, B., KETTERER, B. The role of glutathione and glutathione transferases in chemical carcinogenesis. Critical Reviews in Biochemistry and Molecular Biology, v.25, n.1, p.47-70, 1990.
FITZGERALD, R.J. Potential uses of caseinophosphopeptides.
International Dairy Journal, v.8, n.5-6, p.451-457, 1998.
FOX, P.F. et al. Fundamentals of cheese science. New York: Aspen, 2000. 587p.
HAQUE, E.; CHAND, R. Antihypertensive and antimicrobial bioactive peptides from milk proteins. European Food Research and Technology, v.227, n.1, p.7-15, 2008.
HARTMANN, R.; MEISEL, H. Food-derived peptides with biological activity: from research to food applications. Current Opinion in Biotechnology, v.18, n.2, p.163-169, 2007.
HATA, Y. et al. A placebo-controlled study of the effect of sour milk on blood pressure in hypertensive subjects. The American Journal of Clinical Nutrition, v.64, n.5, p.767-771, 1996.
IKEDA, K. et al. Urocortin, a newly identified corticotropin-releasing factor-related mammalian peptide, stimulates atrial natriuretic peptide and brain natriuretic peptide secretions from neonatal rat cardiomyocytes. Biochemical and Biophysical Research Communications, v.250, n.2, p.298-304, 1998.
JAUHIAINEN, T. et al. Lactobacillus helveticus fermented milk reduces arterial stiffness in hypertensive subjects. International Dairy Journal, v.17, n.10, p.1209–1211, 2007.
KORHONEN, H. Milk-derived bioactive peptides: From science to applications. Journal of Functional Foods I, v.1, n.2, p.177-187, 2009.
KORHONEN, H.; PIHLANTO, A. Bioactive peptides: Production and functionality. International Dairy Journal, v.16, n.9, p.945-960, 2006.
LAHOV, E., REGELSON, W. Antibacterial and stimulating casein-derives substances from milk: casecidin, isracidin peptides. Food and Chemical Toxicology, v.34, n.1, p.131-145, 1996.
LIGNITTO, L. at al. Angiotensin-converting enzyme inhibitory activity of water-soluble extracts of Asiago d’allevo cheese. International Dairy Journal, v.20, n.1, p.11-17, 2010.
MCINTOSH, G.H.; LE LEU, R.K. The influence of dietary proteins on colon cancer risk. Nutrition Research, v.21, n.7, p.1053-1066, 2001.
MCINTOSH, G.H. et al. Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats. Journal of Nutrition, v.125, n.4, p.809-816, 1995.
MEISEL, H. Overview on milk protein-derived peptides. International Dairy Journal, v.8, n.5, p. 363-373, 1998.
MEISEL, H.; BOCKELMANN, W. Bioactive peptides encrypted in milk proteins: proteolytic activation and thropho-functional properties. Antonie van Leeuwenhoek, v.76, n.1-4, p.207-215, 1999.
MELO, A. Soro do leite estimula sistema imunológico. Ciência Hoje on-line, 2006. Disponível em: http://cienciahoje.uol.com.br/controlPanel/materia/view/2929. Acesso em: 12 mar. 2013.
NABET, P.; LINDEN, G. Constituants bioactifs in leits nutrition et same. Tec&Doc, p.169-187, 2001.
NAGAOKA, S. et al. Comparative studies on the serum cholesterol lowering action of whey protein and soybean protein in rats. Bioscience, biotechnology, and biochemistry, v.56, n.9, p.1484-1485, 1992.
NEESER, J.R. et al. In vitro modulation of oral bacterial adhesion to saliva-coated hydroxyapatite beads by milk casein derivatives. Oral Microbiology and Immunology, v.4, n.9, p.193-201, 1994.
OLIVEIRA, D.S.; TIMM, C.D. Instabilidade da caseína em leite sem acidez adquirida. Revista Portuguesa de Ciências Veterinárias, v.102, n.1, p.435–451, 2007.
PACHECO, M.T.B. et al. Efeito de um hidrolisado de proteínas de soro de leite e de seus peptídeos na proteção de lesões ulcerativas da mucosa gástricas de ratos. Revista de Nutrição, v.19, n.1, p.47-55, 2006.
PACHECO, M.T.B. et al. Propriedades funcionais de hidrolisados obtidos a partir de concentrados protéicos de soro de leite. Ciência e Tecnologia dos Alimentos, v.25, n.2, p.333-338, 2005.
PAPENBURG, R. Dietary Milk proteins inhibit the evelopment of dimethylhydrazine-induced malignancy. Tumour Biology, v.11, n.3, p.129-136, 1990.
PHELAN, M. et al. Potential bioactive effects of casein hydrolysates on human cultured cells. International Dairy Journal, v.19, n.5, p.279-285, 2009.
PIHLANTO-LEPPÄLA, A.; ROKKA, T.; KORHONEN, H. Angiotensin I converting enzyme inhibitory peptides derived from bovine milk proteins. International Dairy Journal, v.8, n.4, p.325-331, 1998.
PRIPP, A.H. et al. Relantionship between proteolyses and angiotensin-I-converting enzyme inhibition in different cheeses. Food Science and Technology, v.39, n.6, p.677-683, 2006.
ROSANELI, C.F. et al. Efficacy of a Whey Concentrate on the Inhibition of Stomach Ulcerative Lesions Caused by Ethanol
Ingestion. Journal of Medicinal Food, v.5, n.4, p.221-228, 2002.
ROSANELI, C.F. at al. Protective Effect of Bovine Milk Whey Protein Concentrate on the Ulcerative Lesions Caused by Subcutaneous Administration of Indomethacin. Journal of Medicinal Food, v.7, n.3, p.309-314, 2004.
ROUFIK, S.; GAUTHIER, S. F.; TURGEON, S. L. In vitro digestibility of bioactive peptides derived from bovine β-lactoglobulin. International Dairy Journal, v.16, n.4, p.294-302, 2006.
ROY, M.K. et al. Peptides From the N-terminal End of Bovine Lactoferrin Induce Apoptosis in Human Leukemic (HL-60) Cells. Journal of Dairy Science, v.85, n.9, p.2065-2074, 2002.
SAINT-SAUVEUR, D. et al. Immunomodulating properties of a whey protein isolate, its enzymatic digest and peptide fractions. International Dairy Journal, v.18, n.3, p.260- 270, 2008.
SANO, J. et al. Effect of casein hydrolysate, prepared with protease derived from Aspergillus oryzae, on subjects with high-normal blood pressure or mild hypertension. Journal of Medicinal Food, v.8, n.4, p.423-430, 2005.
SCHANBACHER, F.L. et al. Milk-born bioactive peptides. International Dairy Journal, v.8, n.5-6, p.393-403, 1998.
SEPPO, L. et al. A fermented milk high in bioactive peptides has a blood pressure–lowering effect in hypertensive subjects. The American Journal of Clinical Nutrition, v.77, n. 2, p.326-330, 2003.
SGARBIERI, V. C. Propriedades fisiológicas-funcionais das proteínas do soro de leite. Revista de Nutrição, v.17, n.4, p.397-409, 2004.
SHAH, N. P. Effects of milk-derived bioactives: an overview. British Journal of Nutrition, v.84, s.1, S3-S10, 2000.
SHAHIDI, F.; ZHONG, Y. Bioactive peptides. Journal of AOAC International, v.91, n.4, p.914-931, 2008.
SILVA, S.V.; MALCATA, F.X. Caseins as source of bioactive peptides. International Dairy Journal, v.15, n.1, p.1-15, 2005.
STURNER, R.A.; CHANG, K.J. Opioid peptide content in infant formulas. Pediatric Research, v.23, p.4–10, 1988.
TIDONA, F. et al. Bioactive peptides in dairy. Italian Journal of Animal Science, v.8, n.3, p.315-340, 2008.
TORRUCO-UCO, J.G. et al. Péptidos antihipertensivos, uma alternativa de tratamiento de origen natural: uma revisión. Ciencia y Tecnología Alimentaria, v.6, n.2, p.158-168, 2008.
TRIGO, J.M. et al. The endogenous opioid system: a common substrate in drug addiction. Drug and Alcohol Dependence, v.108, n.3, p.183-194, 2010.
WALZEM, R.L. Propriedades benéficas à saúde das proteínas de soro e frações de soro. Produtos e bebidas nutricionais. Texas A & M University, p. 1-8, 1999.
