Ratos Diabéticos-Induzidos Submetidos a Infusão de Momordica Charantia l.
Keywords:Diabetes, GLP-1, Momordica Charantia L.
AbstractObjetivou-se caracterizar alterações clínicas e laboratoriais em ratos com diabetes submetidos à infusão aquosa do pó dos frutos de Momordica charantia L. (MC). Dezesseis ratos foram induzidos ao diabetes por via intraperitoneal de aloxano. O grupo Diabético apresentou uma redução de 2,68% e o Diabético + MC uma redução de 11,79% no peso corporal. O grupo Diabético apresentou um aumento médio de 34,82% e o grupo Diabético + MC um aumento médio de 27,05% na glicemia. A média dos níveis sanguíneos do GLP-1 nos animais do Grupo Diabético + MC foi 32,73% maior quando comparado com o grupo Diabético. Não houve diferença (P>0,05) nos valores da enzima alanina aminotransferase dos grupos Controle e Diabético, quando comparados com os grupos Controle + MC e Diabético + MC respectivamente. Esses resultados revelam que a MC foi capaz de promover um aumento dos níveis do GLP-1, atenuou a elevação glicêmica, reduziu o ganho de peso não alterando a função hepática analisada.
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