Skin secretion of Phyllomedusa camba as a source of molecules against Acinetobacter baumannii
DOI:
https://doi.org/10.5902/2179460X90544Keywords:
Acinetobacter baumannii, Multi-resistant bacteria, Molecular docking, AnuranAbstract
In light of the multi-drug resistance of Acinetobacter baumannii to commercially available antibiotics, the search for new effective molecules against this bacterium is fundamental. In this study, metabolites present in the skin secretion of the anuran Phyllomedusa camba were identified using mass spectrometry. Among the molecules of interest found in the skin secretion of the anuran, 147 were tested in silico via molecular docking against the penicillin-binding protein and the 30S ribosome targets of A. baumannii. The molecular docking results indicated promising molecules against A. baumannii. In vitro assays were conducted to evaluate the antimicrobial activity of the crude skin secretion of P. camba against the standard strain of A. baumannii (ATCC 19606). The results showed antimicrobial activity for the secretion of P. camba, with a minimum inhibitory concentration (MIC) of 50 µg/mL and an IC50 of 28.65 µg/mL. Compared to results found in the literature, the obtained MIC and IC50 values appear promising. Bioprospecting in anurans presents itself as an alternative for the discovery of new drugs against multi-resistant bacteria.
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