Aplicação de nanotubos de carbono na construção de biossensores: revisão

Autores

DOI:

https://doi.org/10.5902/2179460X94734

Palavras-chave:

Nanocompósitos, Nanotecnologia, Sensores

Resumo

Os biossensores são dispositivos capazes de detectar uma variedade de compostos e podem ser usados para medicina, controle de qualidade de alimentos e segurança ambiental. Os nanotubos de carbono (CNT) são materiais que apresentam propriedades promissoras ao atuar como componentes para biossensores, oferecendo desempenho elétrico superior como transistores de efeito em dispositivos químicos e biológicos. Portanto, o objetivo deste trabalho foi elaborar uma revisão bibliográfica sobre o uso de biossensores baseados em CNT para detectar uma variedade de analitos importantes, como biomarcadores tumorais, neurotransmissores, vírus, glicose e peróxido de hidrogênio. Desta forma, foram realizadas buscas nas bases de dados PubMed (US National Library of Medicine), Web of Science e Scopus, com os seguintes descritores: “carbon nanotube”, “composite” e “biosensor”. Os critérios de inclusão foram definidos como artigos originais escritos em língua inglesa e publicados nos últimos 5 anos, totalizando 24 artigos. Os resultados mostraram que os biossensores baseados em CNT têm baixo limite de detecção, alta sensibilidade e reprodutibilidade, enquanto os CNT oferecem controle de adsorção, reatividade, estabilidade térmica, flexibilidade e condutividade eletrônica. Portanto, os biossensores baseados em CNT podem fornecer detecção rápida e altamente sensível para uma ampla gama de aplicações, com algumas vantagens sobre os métodos padrão atuais, como custos mais baixos e maior acessibilidade. No entanto, mesmo com suas importantes capacidades, os biossensores ainda apresentam alguns desafios antes de serem aplicados na vida cotidiana, e os estudos devem focar em aprimorar a funcionalidade desses dispositivos em pH fisiológico e temperatura ambiente e corporal, mantendo sua sensibilidade e estabilidade por períodos mais longos.

Downloads

Não há dados estatísticos.

Biografia do Autor

Éricles Forrati Machado, Universidade Franciscana

Mestrado em Nanociências pela Universidade Franciscana.

Maria Luiza Machado Teixeira, Universidade Franciscana

Mestrado em Nanociências pela Universidade Franciscana.

Bruno Silveira Levy, Universidade Franciscana

Mestrado em Nanociências pela Universidade Franciscana.

William Leonardo da Silva, Universidade Franciscana

Doutorado em Engenharia Química pela Universidade Federal do Rio Grande do Sul.

Júlia Kubaszewski Nunes, Universidade Franciscana

Graduação em Biomedicina pela Universidade Franciscana.

Referências

Abdullah, C. S., Alam, S., Aishwarya, R., Miriyala, S., Bhuiyan, M. A. N., Panchatcharam, M., Pattillo, C. B., Orr, A. W., Sadoshima, J., Hill, J. A., & Bhuiyan, M. S. (2019). Doxorubicin-induced cardiomyopathy associated with inhibition of autophagic degradation process and defects in mitochondrial respiration. Scientific Reports, 9(1). https://doi.org/10.1038/s41598-018-37862-3

Abid, S. A., Muneer, A. A., Al-Kadmy, I. M. S., Sattar, A. A., Beshbishy, A. M., Batiha, G. E. S., & Hetta, H. F. (2021). Biosensors as a future diagnostic approach for COVID-19. Life Sciences, 273, 119117. https://doi.org/10.1016/j.lfs.2021.119117

Alvarez-Paguay, J., Fernández, L., Bolaños-Méndez, D., González, G., & Espinoza-Montero, P. J. (2022). Evaluation of an electrochemical biosensor based on carbon nanotubes, hydroxyapatite and horseradish peroxidase for the detection of hydrogen peroxide. Sensing and Bio-Sensing Research, 37(1), 1–14. https://doi.org/10.1016/j.sbsr.2022.100514

Anshori, I., Rizalputri, L. N., Althof, R. R., Surjadi, S. S., Harimurti, S., Gumilar, G., Yuliarto, B., & Handayani, M. (2021). Functionalized multi-walled carbon nanotube/silver nanoparticle (f-MWCNT/AgNP) nanocomposites as non-enzymatic electrochemical biosensors for dopamine detection. Nanocomposites, 7(1), 97–108. https://doi.org/10.1080/20550324.2021.1948242

Arcus, V. L., van der Kamp, M. W., Pudney, C. R., & Mulholland, A. J. (2020). Enzyme evolution and the temperature dependence of enzyme catalysis. Current Opinion in Structural Biology, 65, 96–101. https://doi.org/10.1016/j.sbi.2020.06.001

Banerjee, S., McCracken, S., Hossain, M. F., & Slaughter, G. (2020). Electrochemical detection of neurotransmitters. Biosensors, 10(8), 101. https://doi.org/10.3390/bios10080101

Britt, K. L., Cuzick, J., & Phillips, K. A. (2020). Key steps for effective breast cancer prevention. Nature Reviews Cancer, 20(8), 417–436. https://doi.org/10.1038/s41568-020-0266-x

Caygill, R. L., Blair, G. E., & Millner, P. A. (2010). A review on viral biosensors to detect human pathogens. Analytica Chimica Acta, 681(1–2), 8–15. https://doi.org/10.1016/j.aca.2010.09.038

Chang, J., Wang, X., Wang, J., Li, H., & Li, F. (2019). Nucleic acid-functionalized metal–organic framework-based homogeneous electrochemical biosensor for simultaneous detection of multiple tumor biomarkers. Analytical Chemistry, 91(5), 3604–3610. https://doi.org/10.1021/acs.analchem.8b05599

Channer, B., Matt, S. M., Nickoloff-Bybel, E. A., Pappa, V., Agarwal, Y., Wickman, J., & Gaskill, P. J. (2022). Dopamine, immunity, and disease. Pharmacological Reviews, 75(1), 62–158. https://doi.org/10.1124/pharmrev.122.000618

Chauhan, N., Balayan, S., & Jain, U. (2020). Sensitive biosensing of neurotransmitter: 2D material wrapped nanotubes and MnO2 composites for the detection of acetylcholine. Synthetic Metals, 263, 116354. https://doi.org/10.1016/j.synthmet.2020.116354

Chen, D., Sun, X., Guo, Y., Qiao, L., & Wang, X. (2014). Acetylcholinesterase biosensor based on multi-walled carbon nanotubes-SnO2-chitosan nanocomposite. Bioprocess and Biosystems Engineering, 38(2), 315–321. https://doi.org/10.1007/s00449-014-1270-x

Choi, J. R. (2020). Development of point-of-care biosensors for COVID-19. Frontiers in Chemistry, 8. https://doi.org/10.3389/fchem.2020.00517

Comba, F. N., Romero, M. R., Garay, F. S., & Baruzzi, A. M. (2018). Mucin and carbon nanotube-based biosensor for detection of glucose in human plasma. Analytical Biochemistry, 550, 34–40. https://doi.org/10.1016/j.ab.2018.04.006

Danne, T., et al. (2017). International consensus on use of continuous glucose monitoring. Diabetes Care, 40(12), 1631–1640. https://doi.org/10.2337/dc17-1600

De Luna, P., Mahshid, S. S., Das, J., Luan, B., Sargent, E. H., Kelley, S. O., & Zhou, R. (2017). High-curvature nanostructuring enhances probe display for biomolecular detection. Nano Letters, 17(2), 1289–1295. https://doi.org/10.1021/acs.nanolett.6b05153

Dong, M., Gao, Z., Zhang, Y., Cai, J., Li, J., Xu, P., Jiang, H., Gu, J., & Wang, J. Wu, J. (2023). Ultrasensitive electrochemical biosensor for detection of circulating tumor cells based on a highly efficient enzymatic cascade reaction. RSC Advances, 13(19), 12966–12972. https://doi.org/10.1039/D3RA01160G

Dong, Q., Ryu, H., & Lei, Y. (2021). Metal oxide based non-enzymatic electrochemical sensors for glucose detection. Electrochimica Acta, 370, 137744. https://doi.org/10.1016/j.electacta.2021.137744

Duffy, M. J. (2020). Biomarkers for prostate cancer: Prostate-specific antigen and beyond. Clinical Chemistry and Laboratory Medicine, 58(3), 326–339. https://doi.org/10.1515/cclm-2019-0693

Farzin, L., Sadjadi, S., Shamsipur, M., & Sheibani, S. (2019). An immunosensing device based on inhibition of mediator's faradaic process for early diagnosis of prostate cancer using bifunctional nanoplatform reinforced by carbon nanotube. Journal of Pharmaceutical and Biomedical Analysis, 172, 259–267. https://doi.org/10.1016/j.jpba.2019.05.008

Fenollar, F., & Mediannikov, O. (2018). Emerging infectious diseases in Africa in the 21st century. New Microbes and New Infections, 26(1), 10–18. https://doi.org/10.1016/j.nmni.2018.09.004

Ferrier, D. C., & Honeychurch, K. C. (2021). Carbon nanotube (CNT)-based biosensors. Biosensors, 11(12), 1–33. https://doi.org/10.3390/bios11120486

Galant, A. L., Kaufman, R. C., & Wilson, J. D. (2015). Glucose: Detection and analysis. Food Chemistry, 188, 149–160. https://doi.org/10.1016/j.foodchem.2015.04.071

Guerrero, L. A., Fernández, L., González, G., Montero-Jiménez, M., Uribe, R., Díaz Barrios, A., & Espinoza-Montero, P. J. (2020). Peroxide electrochemical sensor and biosensor based on nanocomposite of TiO2 nanoparticle/multi-walled carbon nanotube modified glassy carbon electrode. Nanomaterials, 10(1), 64. https://doi.org/10.3390/nano10010064

Harrison, S., Tilling, K., Turner, E. L., Martin, R. M., Lennon, R., Lane, J. A., Donovan, J. L., Hamdy, F. C., Neal, D. E., Bosch, J. & Jones, H. E. (2020). Systematic review and meta-analysis of the associations between body mass index, prostate cancer, advanced prostate cancer, and prostate-specific antigen. Cancer Causes & Control, 31(5), 431–449. https://doi.org/10.1007/s10552-020-01291-3

Hasan, M. R., Ahommed, M. S., Daizy, M., Bacchu, M. S., Ali, M. R., Al-Mamun, M. R., Aly, M. A. S., Khan, M. Z. H., & Hossain, S. I. (2021). Recent development in electrochemical biosensors for cancer biomarkers detection. Biosensors and Bioelectronics: X, 8, 100075. https://doi.org/10.1016/j.biosx.2021.100075

Hossain, M. F., & Slaughter, G. (2020). PtNPs decorated chemically derived graphene and carbon nanotubes for sensitive and selective glucose biosensing. Journal of Electroanalytical Chemistry, 861, 113990. https://doi.org/10.1016/j.jelechem.2020.113990

Huang, X., Xu, S., Zhao, W., Xu, M., Wei, W., Luo, J., Li, X., & Liu, X. (2020). Screen-printed carbon electrodes modified with polymeric nanoparticle-carbon nanotube composites for enzymatic biosensing. ACS Applied Nano Materials, 3(1), 9158–9166. https://doi.org/10.1021/acsanm.0c01800

Hubbell, E., Clarke, C. A., Aravanis, A. M., & Berg, C. D. (2021). Modeled reductions in late-stage cancer with a multi-cancer early detection test. Cancer Epidemiology and Prevention Biomarkers, 30(3), 460–468. https://doi.org/10.1158/1055-9965.EPI-20-1134

Kalinke, C., Crapnell, R. D., Sigley, E., Whittingham, M. J., de Oliveira, P. R., Brazaca, L. C., Janegitz, B. C., Bonacin, J. A. & Banks, C. E. (2023). Recycled additive manufacturing feedstocks with carboxylated multi-walled carbon nanotubes toward the detection of yellow fever virus cDNA. Chemical Engineering Journal, 467, 143513. https://doi.org/10.1016/j.cej.2023.143513

Khristunova, E., Dorozhko, E., Korotkoca, E., Kratochvil, B., Vyskocill, V., & Barek, J. (2020). Label-free electrochemical biosensors for the determination of Flaviviruses: Dengue, Zika, and Japanese encephalitis. Sensors, 20(16), 4600. https://doi.org/10.3390/s20164600

Klein, M. O., Battagello, D. S., Cardoso, A. R., Hauser, D. N., Bittencourt, J. C., & Correa, R. G. (2018). Dopamine: Functions, signaling, and association with neurological diseases. Cellular and Molecular Neurobiology, 39(1), 31–59. https://doi.org/10.1007/s10571-018-0632-3

Li, C., Zhang, H., Wu, P., Gong, Z., Xu, G., & Cai, C. (2020). Determination of hydrogen peroxide released from cancer cells by a Fe-organic framework/horseradish peroxidase-modified electrode. Analytica Chimica Acta, 1135(1), 132–141. https://doi.org/10.1039/c0an00825g

Li, J., Si, Y., Park, Y. E., Choi, J. S., Jung, S. M., Lee, J. E. & Hye, J. L. (2021). A serotonin voltammetric biosensor composed of carbon nanocomposites and DNA aptamer. Mikrochimica Acta, 188(4). https://doi.org/10.1007/s00604-021-04798-x

Ma, J. L., Yin, B. C., Wu, X., & Ye, B. C. (2016). Simple and cost-effective glucose detection based on carbon nanodots supported on silver nanoparticles. Analytical Chemistry, 89(2), 1323–1328. https://doi.org/10.1021/acs.analchem.6b04259

Mahmood, Z., Alrefai, H., Hetta, H. F., Kader, H. A., Munawar, N., Rahman, S. A., Elshaer, S., Batiha, G. E. S., & Muhammad, K. (2020). Investigating virological, immunological, and pathological avenues to identify potential targets for developing COVID-19 treatment and prevention strategies. Vaccines, 8(3), 443. https://doi.org/10.3390/vaccines8030443

Makableh, Y., Athamneh, T., Ajlouni, M., Hijazi, S., & Alnaimi, A. (2023). Enhanced response and selective gold nanoparticles/carbon nanotubes biosensor for the early detection of HER2 biomarker. Sensors and Actuators Reports, 5, 100158. https://doi.org/10.1016/j.snr.2023.100158

Marazziti, D. (2017). Understanding the role of serotonin in psychiatric diseases. F1000Research, 6. https://doi.org/10.12688/f1000research.10094.1

Mobed, A., Hasanzadeh, M., Ahmadalipour, A., & Fakhari, A. (2020). Recent advances in the biosensing of neurotransmitters: Material and method overviews towards the biomedical analysis of psychiatric disorders. Analytical Methods, 12(4), 557–575. https://doi.org/10.1039/C9AY02390A

Moon, J. M., Thapliyal, N., Hussain, K. K., Goyal, R. N., & Shim, Y. B. (2018). Conducting polymer-based electrochemical biosensors for neurotransmitters: A review. Biosensors and Bioelectronics, 102, 540–552. https://doi.org/10.1016/j.bios.2017.11.069

Murphy, M., Theyagarajan, K., Prabusankar, G., Senthilkumar, S., & Thenmozhi, K. (2019). Electrochemical biosensor for the detection of hydrogen peroxide using cytochrome c covalently immobilized on carboxyl functionalized ionic liquid/multiwalled carbon nanotube hybrid. Applied Surface Science, 492, 718–725. https://doi.org/10.1016/j.apsusc.2019.06.283

Nichols, S. P., Koh, A., Storm, W. L., Shin, J. H., & Schoenfisch, M. H. (2013). Biocompatible materials for continuous glucose monitoring devices. Chemical Reviews, 113(4), 2528–2549. https://doi.org/10.1021/cr300387j

Octavia, Y., Tocchetti, C. G., Gabrielson, K. L., Janssens, S., Crijns, H. J., & Moens, A. L. (2012). Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies. Journal of Molecular and Cellular Cardiology, 52(6), 1213–1225. https://doi.org/10.1016/j.yjmcc.2012.03.006

Palomar, Q., Xu, X., Gondran, C., Holzinger, M., Cosnier, S., & Zhang, Z. (2020). Voltammetric sensing of recombinant viral dengue virus 2 NS1 based on Au nanoparticle–decorated multiwalled carbon nanotube composites. Microchimica Acta, 187, 1–10. https://doi.org/10.1007/s00604-020-04339-y

Patel, S. K., Surve, J., Parmar, J., Ahmed, K., Bui, F., M., & Al-Zahrani, F. A. (2023). Recent advances in biosensors for detection of COVID-19 and other viruses. IEEE Reviews in Biomedical Engineering, 16, 22–37. https://doi.org/10.1109/RBME.2022.3212038

Rajeshwari, V., Vedhi, C., & Fernando, J. (2022). Dopamine sensor based on core-shell poly paraphenylene diamine/titanium dioxide/multiwalled carbon nanotube nanocomposite. Materials Today: Proceedings, 68, 287–293. https://doi.org/10.1016/j.matpr.2022.05.179

Rizo, J. (2018). Mechanism of neurotransmitter release coming into focus. Protein Science, 27(8), 1364–1391. https://doi.org/10.1002/pro.3445

Sharifi, J., & Fayazfar, H. (2021). Highly sensitive determination of doxorubicin hydrochloride antitumor agent via a carbon nanotube/gold nanoparticle based nanocomposite biosensor. Bioelectrochemistry, 139, 107741. https://doi.org/10.1016/j.bioelechem.2021.107741

Shu, Y., Lu, Q., Yuan, F., Tao, Q., Jin, D., Yao, H., Xu, Q., & Hu, X. (2020). Stretchable electrochemical biosensing platform based on Ni-MOF composite/Au nanoparticle-coated carbon nanotubes for real-time monitoring of dopamine released from living cells. ACS Applied Materials & Interfaces, 12(44), 49480–49488. https://doi.org/10.1021/acsami.0c16060

Siegel, R. L., Miller, K. D., & Jemal, A. (2019). Cancer statistics, 2019. CA: A Cancer Journal for Clinicians, 69(1), 7–34. https://doi.org/10.3322/caac.21551

Singh, M., Kaur, M., Kukreja, H., Chugh, R., Silakari, O., & Singh, D. (2013). Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection. European Journal of Medicinal Chemistry, 70, 165–188. https://doi.org/10.1016/j.ejmech.2013.09.050

Sriwichai, S., & Phanichphant, S. (2022). Fabrication and characterization of electrospun poly (3-aminobenzylamine)/functionalized multi-walled carbon nanotubes composite film for electrochemical glucose biosensor. Express Polymer Letters, 16(4), 439–450. https://doi.org/10.3144/expresspolymlett.2022.32

Sun, Z., Liu, H., & Wang, X. (2022). Thermal self-regulatory intelligent biosensor based on carbon-nanotubes-decorated phase-change microcapsules for enhancement of glucose detection. Biosensors and Bioelectronics, 195, 113586. https://doi.org/10.1016/j.bios.2021.113586

Thanihaichelvan, M., Surendran, S. N., Kumanan, T., Sustharsini, U., Ravirajan, P., Valluvan, R., & Tharsika, T. (2021). Selective and electronic detection of COVID-19 (Coronavirus) using carbon nanotube field effect transistor-based biosensor: A proof-of-concept study. Materials Today: Proceedings, 49(7), 2546–2549. https://doi.org/10.1016/j.matpr.2021.05.011

World Health Organization. (2023). Weekly epidemiological update on COVID-19. https://www.who.int/publications/m/item/weekly-epidemiological-update-on-covid-19---8-june-2023

Yang, G., Xiao, Z., Tang, C., Deng, Y., Huang, H., & He, Z. (2019). Recent advances in biosensor for detection of lung cancer biomarkers. Biosensors and Bioelectronics, 141, 111416. https://doi.org/10.1016/j.bios.2019.111416

Yao, X., Zhang, Y., Jin, W., Hu, W., & Cui, Y. (2021). Carbon nanotube field-effect transistor-based chemical and biological sensors. Sensors, 21(3), 1–18. https://doi.org/10.3390/s21030995

Zamzami, M. A., Rabbani, G., Ahmad, A., Basalah, A. A., Al-Sabban, W. H., Nate Ahn, S., & Choudhry, H. (2022). Carbon nanotube field-effect transistor (CNT-FET)-based biosensor for rapid detection of SARS-CoV-2 (COVID-19) surface spike protein S1. Bioelectrochemistry, 143, 107982. https://doi.org/10.1016/j.bioelechem.2021.107982

Zou, L., Wang, S., & Qiu, J. (2020). Preparation and properties of a glucose biosensor based on an ionic liquid-functionalized graphene/carbon nanotube composite. New Carbon Materials, 35(1), 12–19. https://doi.org/10.1016/S1872-5805(20)60472-3

Publicado

2026-05-28

Como Citar

Machado, Éricles F., Teixeira, M. L. M., Levy, B. S., Silva, W. L. da, & Nunes, J. K. (2026). Aplicação de nanotubos de carbono na construção de biossensores: revisão. Ciência E Natura, 48, e94734. https://doi.org/10.5902/2179460X94734

Edição

Seção

Química

Artigos mais lidos pelo mesmo(s) autor(es)