Efeito do Ultrassom Terapêutico Sobre a Retenção e Manutenção da Atividade Antioxidante
Keywords:Drug delivery, permeation, ultrasound, biomembrane retention, antioxidant activity.
O objetivo do presente trabalho foi avaliar a retenção do extrato glicólico de A. montana usando biomembranas, além de determinar o efeito do ultrassom terapêutico sobre a capacidade antioxidante deste extrato. Amostras de biomembranas foram tratadas em célula de difusão vertical em presença de hidrogel contendo extrato de A. montana com e sem aplicação de ultrassom (3 MHz, 1 W/cm2). Biomembranas foram submetidas ao ultrassom e analisadas, em termos de retenção de extrato, nos tempos de 4 e 150 min., sendo que a quantidade retida foi de 93.5 and 69.03% , respectivamente, indicando que a aplicação de US terapêutico promove o aumento de permeação de ativos. Ainda, a técnica de voltametria cíclica foi utilizada para avaliar a capacidade antioxidante do extrato de A. montana, sendo utilizados eletrodos impressos de Co-ftalocianina, indicando que após a aplicação de ultrassom terapêutico a capacidade antioxidante dos extratos foi diminuída. Desta forma, a partir do estudo realizado verificou-se que após aplicação do US terapêutico em extratos de A. montana, houve aumento da permeação do composto e diminuição de sua atividade antioxidante.
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