Clinical relevance of therapeutic drug monitoring for amikacin and gentamicin

Autores/as

DOI:

https://doi.org/10.5902/2236583474576

Palabras clave:

Antibiotics, Aminoglycosides, Infection, Adverse effects

Resumen

Aminoglycoside antibiotics (AG) are widely prescribed to treat severe bacterial infections I in neonates, elderly, and critically ill patients. Considering the global increase in antimicrobial resistance, it is necessary to address this problem by optimizing available resources. Therapeutical drug monitoring (TDM) allows dose individualization and assists in preventing under or overdosage-related events. In this sense, the objective of this review was to analyze scientific evidence in the literature about the clinical importance of TDM for AG, access available data about its benefits, cover the main topics and provide an overview of this practice. PubMed and Science Direct databases were searched for: “therapeutic drug monitoring” and “aminoglycosides,” limiting the search to articles published between 2015 and 2022. In total, 26 articles were included in this review. TDM seems to be especially beneficial to elderly, neonates and critically ill patients, and target concentrations and sampling times are already well established, with the most recommended target being Cmax/MIC > 8. However, knowledge and training of the involved staff are essential to implement and interpret the TDM adequately.

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Biografía del autor/a

Nadine Arnold Steffens, Universidad Federal de Santa María

Farmacêutica formada pela Universidade Federal de Santa Maria-RS.Possui mestrado em Ciências Farmacêuticas - Análises Clínicas e Toxicológicas pelo Programa de Pós-Graduação em Ciências Farmacêuticas da mesma instituição, desenvolvendo projeto relacionado ao Monitoramento terapêutico e análises farmacocinéticas de antimicrobianos utilizados em ambiente hospitalar.

Rodrigo Redel Petreceli, Universidad Federal de Santa María

Graduação em Farmácia UFSM, Santa Maria, RS, Brasil. Mestrando em Ciências Farmacêuticas pela UFSM.

Roselaine Lima da Vida, Universidad Federal de Santa María

 Graduação em Farmácia pela Universidade Regional Integrada do Alto Uruguai e das Missões - URI Santiago

Gabrielle Lima Corrêa, Universidad Federal de Santa María

Graduanda em Farmácia pela UFSM, Santa Maria, Estado do Rio Grande do Sul, Brasil.

Estevan Sonego Zimmermann, Universidad de la Florida

Graduação em Farmácia pela UFSM, Santa Maria estado Rio Grande do Sul, País Brasil. Doutorado em Ciências Farmacêuticas UFRGS

Natália Brucker, Universidad Federal de Santa María

Possui graduação em Farmácia pela Universidade Federal de Santa Maria (2008). Doutorado em Ciências Farmacêuticas pela Universidade Federal do Rio Grande do Sul (2013). Participou do Programa de Doutorado Sanduíche no Exterior pelo programa Probral da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) na Universität Hohenhein (Alemanha). Pós-doutorado em Ciências Farmacêuticas na Universidade Federal do Rio Grande do Sul (2014-2015). Atualmente é Professora Adjunta da Universidade Federal de Santa Maria estando vinculada ao Departamento de Fisiologia e Farmacologia. É coordenadora do grupo de pesquisa intitulado "Núcleo de Pesquisa Aplicada em Farmacologia e Toxicologia Clínica". Atua como orientadora do Programa de Pós-Graduação em Farmacologia UFSM na linha de pesquisa toxicologia e nutracêutica e do Programa de Pós-Graduação de Ciências Farmacêuticas UFSM na linha de análises clínicas e toxicológicas.

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Publicado

2023-08-02

Cómo citar

Steffens, N. A., Petreceli, R. R., Vida, R. L. da, Corrêa, G. L., Zimmermann, E. S., & Brucker, N. (2023). Clinical relevance of therapeutic drug monitoring for amikacin and gentamicin. Saúde (Santa Maria), 49(2), e74576. https://doi.org/10.5902/2236583474576

Número

Vol. 49 Núm. 2 (2023): Revista Saúde (Santa Maria) Ano 2023

Sección

Artigos de Revisão

Licencia

Derechos de autor 2023 Nadine Arnold Steffens, Rodrigo Redel Petreceli, Roselaine Lima da Vida, Gabrielle Lima Corrêa , Estevan Sonego Zimmermann, Natalia Brucker

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