Correlation between leukogram and ulcerated periodontal surface area (PISA)
DOI:
https://doi.org/10.5902/2236583470232Keywords:
Inflammation, Periodontal diseases, Leukocyte countAbstract
Objective: The objective of this study was to correlate the impact of the periodontal condition, evaluated through PISA, with the white blood cell count (WBCC). Methods: Full clinical periodontal exam (CPE) and laboratory tests were collected in a representative sample of a rural area in the interior of Rio Grande do Sul. 649 individuals were evaluated (≥18 years) and classified into three groups: Group 1 (n = 522), dentate patients with CPE and WBCC. Group 2 (n = 59), edentulous patients with WBCC. Group 3 (n = 68), patients with only CPE. Correlation between periodontal condition (healthy, mild, moderate and severe periodontitis) and white cell count (total of leukocytes, neutrophils and lymphocytes) was evaluated. PISA was calculated through the clinical insertion level (NIC), probing depth (PS) and bleeding on probing (SS). Results: Group 1 when compared to the others presented higher values for NIC (p <0.05) and lymphocytes (p <0.05). A small correlation between PISA and total WBCC (ρ = 0.13, p <0.05) and PISA and neutrophils (ρ = 0.12; p <0.05) were observed in group 1. Subjects with mild periodontitis presented a large correlation between PISA and total WBCC (ρ = 0.67, p <0.05) and PISA and neutrophils (ρ = 0.72, p <0.05). A small correlation was observed for PISA and total WBCC in healthy subjects (ρ = 0.27, p <0.05), PISA and lymphocytes (ρ = 0.17, p <0.05) in moderate periodontitis and PISA and neutrophils (ρ = 0.15, p <0.05) for severe periodontitis. Final considerations: Although with a small correlation, the inflammatory status associated with periodontal diseases has a systemic repercussion observed on WBCC.
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References
Kassebaum NJ, Smith AGC, Bernabé E, Fleming TD, Reynolds AE, Vos T, Murray CJL, Marcenes W, GBD 2015 Oral Health Collaborators Global, regional, and national prevalence, incidence, and disability- adjusted life years for oral conditions for 195 countries, 1990-2015: a systematic analysis for the global burden of diseases, injuries, amd risk factors. J Dent Res. 2017;96:380–387.
Bascones-Martínez A, Muñoz-Corcuera M, Noronha S, Mota P, Bascones-Ilundain C, Campo-Trapero J. Host defence mechanisms against bacterial aggression in periodontal disease: Basic mechanisms. Med Oral Patol Oral Cir Bucal. 2009;14:680–5.
Li X, Kolltveit KM, Tronstad L, Olsen I. Systemic diseases caused by oral infection. Clin. Microbiol. Rev. 2000; 13: 547-558.
Loos BG, Craandijk J, Hoek FJ, Wertheim-van Dillen PM, der Velden U. Elevation of systemic markers related to cardiovascular diseases in the peripheral blood of periodontitis patients. J Periodontol 2000;71: 1528–1534.
Gaddale R, Mudda J, Karthikeyan I, Desai S, Shinde H, Deshpande P. Changes in cellular and molecular components of peripheral blood in patients with generalized aggressive periodontitis. Journal of Investigative and Clinical Dentistry 2016; 7, 59–64
Anand PS, Sagar DK, Mishra S, Narang S, Kamath KP, Anil S (2016). Total and differential leukocyte counts in the peripheral blood of patients with generalised aggressive periodontitis. Oral Health Prev Dent 2016;14: 443-50
Rastogi P, Singhal R, Sethi A, Agarwal A, Singh VK, Sethi R. Assessment of the effect of periodontal treatment in patients with coronary artery disease: A pilot survey. J Cardiovasc Dis Res 2012;3:124-7.
Mustapha IZ, Debrey S, Oladubu M, Ugarte R. Markers of systemic bacterial exposure in periodontal disease and cardiovascular disease risk: a systematic review and meta-analysis. J Periodontol 2007;78:2289-302.
Pink C, Kocher T, Meisel P, Dorr M, Markus MR, Jablonowski L, et al. Longitudinal effects of systemic inflammation markers on periodontitis. Journal of clinical periodontology. 2015;42(11):988–97.
Negrato CA, Tarzia O, Jovanovic L, Chinellato LE. Periodontal disease and diabetes mellitus. J Appl Oral Sci 2013;21:1–12.
Scannapieco FA, Bush RB, Paju S. Associations between periodontal disease and risk for nosocomial bacterial pneumonia and chronic obstructive pulmonary disease. A systematic review. Ann Periodontol 2003;8: 54–69.
Corbella S, Taschieri S, Fabbro MD, Francetti L, Weinstein R, Ferrazzi E. Adverse pregnancy outcomes and periodontitis: A systematic review and meta-analysis exploring potential association. Quintessence Int 2016;47:193-204.
Kumar BP, Khaitan T, Ramaswamy P, Sreenivasulu P, Uday G, Velugubantla RG. Association of chronic periodontitis with white blood cell and platelet count – A Case Control Study. J Clin Exp Dent. 2014;6(3):214-217.
Nesse W, Abbas F, van der Ploeg I, Spijkervet FK, Dijkstra PU, Vissink A. Periodontal inflamed surface area: quantifying inflammatory burden. J ClinPeriodontol 2008;35:668-73.
MÁRIO, T. G. Aspectos Metodológicos de um Levantamento Epidemiológico Rural e Descrição das Condições Periodontais em Amostra Representativa. Tese (Doutorado em Ciências Odontológicas) Universidade Federal de Santa Maria, Santa Maria, 2017.
WHO. World Health Organization. Diretrizes da OMS para a tiragem de sangue: boas práticas em flebotomia. 2010. p. 125
Eke PI, Page RC, Wei L, Thornton-Evans G, Genco RJ. Update of the case definitions for population-based suveillance of periodontitis. J Periodontol 2012; 83(12): 1449-54.
Brazil. Health's Ministry. SB Brazil Project 2010. Oral health conditions in the Brazilian population. Main results.Brasília-Brazil, 2011.
Park SB, An SY, Han WJ, Park JT. Three-dimensional measurement of periodontal surface area for quantifying inflammatory burden. Periodontal Implant Sciv 2017;47(3):154-164
Phillips AC, Carroll D, Gale CR, Drayson M, Batty GD. Lymphocyte cell counts in middle age are positively associated with subsequent all-cause and cardiovascular mortality. QJM 2011;104: 319–324.
Rana JS, Boekholdt SM, Ridker PM, Jukema JW, Luben R, Bingham SA, et al. Differential leucocyte count and the risk of future coronary artery disease in healthy men and women: the EPIC-Norfolk Prospective Population Study. J Intern Med 2007;262: 678–689.
Shi D, Meng H, Xu L, Zhang L, Chen Z, Feng X, et al. Systemic inflammation markers in patients with aggressive periodontitis: a pilot study. J Periodontol 2008;79: 2340–2346.
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