Possible causes of Burning Mouth Syndrome: a narrative literature review
DOI:
https://doi.org/10.5902/2236583468987Keywords:
Burning mouth, Oral burning, Syndrome causesAbstract
Introduction: Burning Mouth Syndrome is a chronic condition characterized by a burning sensation in the oral mucosa, with an unknown causal factor. The tongue, the anterior region of the palate, and the lips are the most affected sites, and its prevalence is higher among females. Despite a large number of studies, its pathogenesis remains poorly understood, and the discomfort reported by patients can significantly impact their quality of life. Objectives: To present the diagnosis, possible causes, and contributing factors related to Burning Mouth Syndrome. Methods: A search was conducted in the PubMed database in July 2021 using the descriptors “burning mouth” and “syndrome causes.” Results and conclusion: Burning Mouth Syndrome is more prevalent in peri- or postmenopausal women; it is a multifactorial condition, and when associated with the use of medications and physiological xerostomia, it may be a predisposing factor for the burning sensation in the mouth. Its diagnosis is imprecise and is made by excluding other possible causes. When it is associated with a pre-existing medical condition, it is classified as secondary; when the causal factor is idiopathic, it is classified as primary. The symptoms can be alleviated by informing the patient that it is a relatively common and non-serious condition.
Downloads
References
Kamala KA, Sankethguddad S, Sujith SG, Tantradi P. Burning mouth syndrome. Indian J Palliat Care. 2016;22(1):74–9.
Klein B, Thoppay JR, De Rossi SS, Ciarrocca K. Burning Mouth Syndrome. Vol. 38, Dermatologic Clinics. W.B. Saunders; 2020. p. 477–83.
Yoo HS, Jin SH, Lee YJ, Song CM, Ji YB, Tae K. The role of psychological factors in the development of burning mouth syndrome. Int J Oral Maxillofac Surg [Internet]. 2018 Mar;47(3):374–8. Available from: https://linkinghub.elsevier.com/retrieve/pii/S0901502717316363
Chiang CP, Wu YH, Wu YC, Chang JYF, Wang YP, Sun A. Anemia, hematinic deficiencies, hyperhomocysteinemia, and serum gastric parietal cell antibody positivity in 884 patients with burning mouth syndrome. J Formos Med Assoc [Internet]. 2020;119(4):813–20. Available from: https://doi.org/10.1016/j.jfma.2019.10.013
Bonenfant D, Rompré P, Rei N, Jodoin N, Soland V, Rey V, et al. Characterization of Burning Mouth Syndrome in Patients with Parkinson’s Disease. J Oral Facial Pain Headache. 2016;30(4):318–22.
Bender SD. Burning Mouth Syndrome. Vol. 62, Dental Clinics of North America. W.B. Saunders; 2018. p. 585–96.
Beneng K, Renton T. Pain Part 8: Burning mouth syndrome. Dent Update. 2016;43(3):254–6.
Nasri-Heir C, Shigdar D, Alnaas D, Korczeniewska OA, Eliav R, Heir GM. Primary burning mouth syndrome: Literature review and preliminary findings suggesting possible association with pain modulation. Quintessence Int (Berl). 2018;49(1):49–60.
Neville BW, Damm DD, Allen CM, Chi AC. Patologia Oral e Maxilofacial Quarta Edição [Internet]. Elsevier; 2016. Available from: www.mercadolivre.com.br
Moghadam-Kia S, Fazel N. A diagnostic and therapeutic approach to primary burning mouth syndrome. Clin Dermatol [Internet]. 2017;35(5):453–60. Available from: http://dx.doi.org/10.1016/j.clindermatol.2017.06.006
Jääskeläinen SK. Is burning mouth syndrome a neuropathic pain condition? Vol. 159, Pain. NLM (Medline); 2018. p. 610–3.
Sánchez-Herrero A, Vergara-de Caso E, Vera-Álvarez S, Espinosa-Hidalgo I, Silvestre Salvador JF. Burning mouth syndrome triggered by cinnamal present in a denture fixative cream. Contact Dermatitis. 2019;81(2):147–9.
Mukatash-Nimri GE, Al-Nimri MA, Al-Jadeed OG, Al-Zobe ZR, Aburumman KK, Masarwa NA. Patients with burning mouth sensations. A clinical investigation of causative factors in a group of “compete denture wearers” Jordanian population. Saudi Dent J [Internet]. 2017;29(1):24–8. Available from: http://dx.doi.org/10.1016/j.sdentj.2016.10.002
Ritchie A, Kramer JM. Recent Advances in the Etiology and Treatment of Burning Mouth Syndrome. Vol. 97, Journal of Dental Research. SAGE Publications Inc.; 2018. p. 1193–9.
Powell A, Nelson KN, Awosika O, Rengifo-Pardo M, Ehrlich A. Burning Mouth Syndrome and Contact Dermatitis. Dermatitis. 2020;31(4):238–43.
Vellappally. Burning mouth syndrome: A review of etiology, diagnosis, and management. Gen Dent. 2019;67(2):24–9.
Feller L, Fourie J, Bouckaert M, Khammissa RAG, Ballyram R, Lemmer J. Burning Mouth Syndrome: Aetiopathogenesis and Principles of Management. Vol. 2017, Pain Research and Management. Hindawi Limited; 2017.
Campisi G, Giovannelli L, Ammatuna P, Capra G, Colella G, Di Liberto C, et al. Proliferative verrucous vs conventional leukoplakia: No significantly increased risk of HPV infection. Oral Oncol. 2004;40(8):835–40.
Galli F, Lodi G, Sardella A, Vegni E. Role of psychological factors in burning mouth syndrome: A systematic review and meta-analysis. Cephalalgia. 2017;37(3):265–77.
Jong Yeup, Kim YS, Ko I, Kim DK. Association between Burning Mouth Syndrome and the Development of Depression, Anxiety, Dementia, and Parkinson Disease. JAMA Otolaryngol - Head Neck Surg. 2020;146(6):561–9.
Radochová V, Slezák R, Radocha J. Iron Deficiency as Cause of Dysphagia and Burning Mouth (Plummer-Vinson or Kelly-Patterson Syndrome): a Case Report. Acta medica (Hradec Kral [Internet]. 2020;63(3):128–32. Available from: https://dx.doi.org/10.14712/18059694.2020.30
Loňcar-Brzak B, Vidranski V, Andabak-Rogulj A, Vidovíc-Juras D, Todoríc-Laidlaw I, Gabríc D, et al. Salivary hormones and quality of life in female postmenopausal burning mouth patients-A pilot case-control study. Dent J. 2020;8(4):2–8.
Acharya S, Hägglin C, Jontell M, Wenneberg B, Ekström J, Carlén A. Saliva on the oral mucosa and whole saliva in women diagnosed with burning mouth syndrome. Oral Dis. 2018;24(8):1468–76.
Obara T, Naito H, Nojima T, Koga H, Nakao A. Burning Mouth Syndrome Induced by Angiotensin-Converting Enzyme Inhibitors. Cureus. 2020;12(11):12–4.
Aljanobi H, Sabharwal A, Krishnakumar B, Kramer JM. Is it Sjögren’s syndrome or burning mouth syndrome? Distinct pathoses with similar oral symptoms. Oral Surg Oral Med Oral Pathol Oral Radiol [Internet]. 2017;123(4):482–95. Available from: http://dx.doi.org/10.1016/j.oooo.2017.01.005
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Laura Goldschmidt Follmann, Bruna Alessandra Copetti Vasconcellos, Karine Anschau Klagenberg, Gabriele Savariz Zilli, Alexandre Dorneles Pistoia

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
A Declaração de Direito Autoral e os itens a serem observados podem ser visualizados no seguinte link: http://cascavel.ufsm.br/revistas/ojs-2.2.2/index.php/seculoxxi/information/sampleCopyrightWording

