Factors associated with sepsis and conditions that predict death for elderly people with respiratory diseases

Authors

DOI:

https://doi.org/10.5902/2179769285283

Keywords:

Death, Aged, Sepsis, Respiratory Tract Infections, COVID-19

Abstract

Objective: to analyze the factors associated with sepsis, as well as the conditions that predict death in elderly people admitted to Intensive Care Units, with an initial diagnosis of acute respiratory diseases not related to health care. Methodology: mixed cohort epidemiological study, carried out between September 2019 and September 2020. Data were collected from electronic medical charts and associations were checked in bivariate analysis and logistic regression. Results: of the studied 228 elderly people, 125 (54.5%) passed away and 204 (89.5%) had sepsis. Urinary invasive devices (RR=1.754; 95% CI 1.360-2.263), presence of sepsis based on the Sepsis-3 consensus (RR=3.55; 95% CI 1.23-10.27) and Covid-19 (RR=1. 39; 95% CI 1.08-1.78) were predictors for death. Conclusion: the factors associated with sepsis among patients with Covid-19 and other respiratory infections are different. The conditions that predict death for elderly people with acute respiratory infections not related to health care were: sepsis, Covid-19 and urinary invasive device.

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Author Biographies

Taís Ivastcheschen Taques, State University of Ponta Grossa

Enfermeira, Mestre em Ciências da Saúde, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

Ana Claudia Garabeli Cavalli Kluthcovcky, State University of Ponta Grossa

Médica, Doutora, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

Camila Marinelli Martins, State University of Ponta Grossa

Médica veterinária, Doutora, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

Erildo Vicente Muller, State University of Ponta Grossa

Farmacêutico, Doutor, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

Jacy Aurélia Vieira de Sousa, State University of Ponta Grossa

Enfermeira, Doutora, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

Pollyanna Kássia de Oliveira Borges, State University of Ponta Grossa

Cirurgia dentista, Doutora, Universidade Estadual de Ponta Grossa, Ponta Grossa, Paraná, Brasil

References

Lima EJA, Silva JVV, Tenorio CMP, Lima CG, Melo DC, Lima RE , et al. Relação entre doenças crônicas não transmissíveis e o tempo de internação de idosos em unidade de terapia intensiva. Braz J Implantol Health Sci. 2023;5(4):2620-32. doi: 10.36557/2674-8169.2023v5n4p2620-2632 DOI: https://doi.org/10.36557/2674-8169.2023v5n4p2620-2632

Sousa DKC, Timóteo PAD, Teotonio VLA, Bezerra ALD, Suárez LAB, Toledo MA, et al. Caracterização dos idosos internados em unidade de terapia intensiva por doença respiratória aguda. Braz Appl Sci Rev. 2021 Feb 11;5(1):378-90. doi: 10.34115/basrv5n1-025 DOI: https://doi.org/10.34115/basrv5n1-025

Tang JW, Lam TT, Zaraket H, Lipkin WI, Drews SJ, Hatchette TF, et al. Global epidemiology of non-influenza rna respiratory viruses: data gaps and a growing need for surveillance. Lancet Infect Dis. 2017;17(10):e320-6. doi: 10.1016/S1473-3099(17)30238-4 DOI: https://doi.org/10.1016/S1473-3099(17)30238-4

Viana RAPP, Machado FR, Souza J. Sepse, um problema de saúde pública: a atuação e colaboração da enfermagem na rápida identificação e tratamento da doença [Internet]. 2ª ed. São Paulo: Conselho Regional de Enfermagem de São Paulo (COREN-SP); 2016 [acesso em 2023 dez 26]. Disponível em: https://portal.coren-sp.gov.br/sites/default/files/sepse_um_problema_de_saude_publica.pdf

Belo GV, Gaspar GLG, Lima LS. Análise dos aspectos epidemiológicos da sepse e da potencial influência da publicação do consenso Sepsis-3 na sua mortalidade no território brasileiro. Rev Saúde (Vassouras). 2020;11(2):44-8. doi: 10.21727/rs.v11i1.2376 DOI: https://doi.org/10.21727/rs.v11i1.2376

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (sepsis-3). JAMA. 2016;315(8):801-10. doi: 10.1001/jama.2016.0287 DOI: https://doi.org/10.1001/jama.2016.0287

Rudd KE, Johnson SC, Agesa KM, Shackelford KA, Tsoi D, Kievlan DR, et al. Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global burden of disease study. Lancet. 2020;395(10219):200-11. doi: 10.1016/S0140-6736(19)32989-7 DOI: https://doi.org/10.1016/S0140-6736(19)32989-7

Instituto Latino Americano da Sepse. Roteiro de implementação de protocolo assistencial gerenciado de sepse [Internet]. 5ª ed. São Paulo (SP): Instituto Latino Americano da Sepse; 2019 [acesso em 2023 dez 26]. Disponível em: https://ilas.org.br/wp-content/uploads/2022/05/roteiro-de-implementacao-isbn-1.pdf

Lobo SM, Rezende E, Mendes CL, Oliveira MC. Mortalidade por sepse no Brasil em um cenário real: projeto UTIs Brasileiras. Rev Bras Ter Intensiva. 2019;31(1):1-4. doi: 10.5935/0103-507X.20190008 DOI: https://doi.org/10.5935/0103-507X.20190008

Bodilsen J, Nielsen PB, Søgaard M, Dalager-Petersen M, Speiser LOZ, Yndigegn T, et al. Hospital admission and mortality rates for non-covid diseases in denmark during covid-19 pandemic: nationwide population based cohort study. BMJ. 2021;373:n1135. doi: 10.1136/bmj.n1135 DOI: https://doi.org/10.1136/bmj.n1135

Domingo L, Comas M, Jansana A, Louro J, Tizón-Marcos H, Cos ML, et al. Impact of covid-19 on hospital admissions and healthcare quality indicators in non-covid patients: a retrospective study of the first covid-19 year in a university hospital in spain. J Clin Med. 2022;11(7):1752. doi: 10.3390/jcm11071752 DOI: https://doi.org/10.3390/jcm11071752

Oliveira MA, Vellarde GC, Sá RAM. Entendendo a pesquisa clínica III: estudos de coorte. Femina [Internet]. 2015 [acesso em 2023 dez 26];43(3):105-10. Disponível em: http://files.bvs.br/upload/S/0100-7254/2015/v43n3/a5116.pdf

Dietrich C, Cardoso JR, Vargas F, Sanchez EC, Dutra FH, Moreira C, et al. Functional ability in younger and older elderlies after discharge from the intensive care unit: a prospective cohort. Rev Bras Ter Intensiva. 2017;29(3):293-302. doi: 10.5935/0103-507X.20170055 DOI: https://doi.org/10.5935/0103-507X.20170055

Zonta FNS, Velasquez PGA, Velasquez LG, Demetrio LS, Miranda D, Silva MCBD. Epidemiological and clinical characteristics of sepse in a public hospital of Paraná. Rev Epidemiol Controle Infecç. 2018;8(3):224-31. doi: 10.17058/reci.v8i3.11438 DOI: https://doi.org/10.17058/reci.v8i3.11438

Kotfis K, Wittebole X, Jaschinski U, Solé-Violán J, Kashyap R, Leone M, et al. A worldwide perspective of sepsis epidemiology and survival according to age: observational data from the ICON audit. J Crit Care. 2019;51:122-32. doi:10.1016/j.jcrc.2019.02.015 DOI: https://doi.org/10.1016/j.jcrc.2019.02.015

World Health Organization (WHO). Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions [Internet]. Geneva (CH): World Health Organization; 2020 [cited from 2023 Dec 26]. Available from: https://apps.who.int/iris/handle/10665/334216

Salminen A. Activation of immunosuppressive network in the aging proc. Ageing Res Rev. 2020;57:100998. doi:10.1016/j.arr.2019.100998 DOI: https://doi.org/10.1016/j.arr.2019.100998

Møgelmose S, Neels K, Beutels P, Hens N. Exploring the impact of population ageing on the spread of emerging respiratory infections and the associated burden of mortality. BMC Infect Dis. 2023;23(1):767. doi: 10.1186/s12879-023-08657-3 DOI: https://doi.org/10.1186/s12879-023-08657-3

Mossini GG, Silva AI, Costa JR, Marcon SS. Prevalência de mortalidade por pneumonia adquirida na comunidade, na população idosa do Paraná, segundo dados do DATASUS. In: Anais do II Congresso de Saúde Coletiva da UFPR [Internet]; 2020 [acesso em 2023 dez 23]; Curitiba, Brasil. Disponível em: https://eventos.ufpr.br/csc/csc20/paper/view/4195

Sousa AFL, Queiroz AAFLN, Oliveira LB, Moura LKB, Andrade D, Watanabe E, et al. Deaths among the Elderly with ICU Infections. Rev Bras Enferm. 2017;70(4):733-9. doi: 10.1590/0034-7167-2016-0611 DOI: https://doi.org/10.1590/0034-7167-2016-0611

Pires HFM, Pereira FC, Ribeiro MS, Silva JDG. Sepse em unidade de terapia intensiva em um hospital público: estudo da prevalência, critérios diagnósticos, fatores de risco e mortalidade. Braz J Dev. 2020; 6(7):53755-73. doi: 10.34117/bjdv6n7-862 DOI: https://doi.org/10.34117/bjdv6n7-862

Esme M, Topeli A, Yavuz BB, Akova M. Infections in the elderly critically-ill patients. Front Med (Lausanne). 2019;6:118. doi: 10.3389/fmed.2019.00118 DOI: https://doi.org/10.3389/fmed.2019.00118

Usman OA, Usman AA, Ward MA. Comparison of SIRS, qSOFA, and NEWS for the early identification of sepsis in the emergency department. Am J Emerg Med. 2019;37(8):1490-7. doi: 10.1016/j.ajem.2018.10.058 DOI: https://doi.org/10.1016/j.ajem.2018.10.058

Liu D, Wang Q, Zhang H, Cui L, Shen F, Chen Y, et al. Viral sepsis is a complication in patients with novel corona virus disease (covid-19). Med Drug Discov. 2020;8:100057. doi: 10.1016/j.medidd.2020.100057 DOI: https://doi.org/10.1016/j.medidd.2020.100057

Gu X, Zhou F, Wang Y, Fan G, Cao B. Respiratory viral sepsis: epidemiology, pathophysiology, diagnosis and treatment. Eur Respir Ver. 2020;29(157):200038. doi: 10.1183/16000617.0038-2020 DOI: https://doi.org/10.1183/16000617.0038-2020

Lin GL, McGinley JP, Drysdale SB, Pollard AJ. Epidemiology and immune pathogenesis of viral sepsis. Front Immunol. 2018;9:2147. doi: 10.3389/fimmu.2018.02147 DOI: https://doi.org/10.3389/fimmu.2018.02147

Evans L, Rhodes A, Alhazzani W, Antonelli M, Coopersmith CM, French C, et al. Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021. Crit Care Med. 2021;47:1181-247. doi:10.1007/s00134-021-06506-y DOI: https://doi.org/10.1007/s00134-021-06506-y

Gao Q, Hu Y, Dai Z, Xiao F, Wang J, Wu J. The epidemiological characteristics of 2019 novel coronavirus diseases (Covid-19) in Jingmen, Hubei, China. Medicine. 2020;99(23):e20605. doi: 10.1097/MD.0000000000020605 DOI: https://doi.org/10.1097/MD.0000000000020605

Tavares CAM, Avelino-Silva TJ, Benard G, Cardozo FAM, Fernandes JR, Girardi ACC, et al. ACE2 expression and risk factors for COVID-19 severity in patients with advanced age. Arq Bras Cardiol. 2020;115(4):701-7. doi:10.36660/abc.20200487 DOI: https://doi.org/10.36660/abc.20200487

Ramalho Neto JM, Viana RAPP, Franco AS, Prado PR, Gonçalves FAF, Nóbrega MML. Diagnósticos/resultados e intervenções de enfermagem para pacientes graves acometidos por covid-19 e sepse. Texto Contexto Enferm. 2020;29:e20200160. doi: 10.1590/1980-265X-TCE-2020-016 DOI: https://doi.org/10.1590/1980-265x-tce-2020-0160

Published

2023-12-18 — Updated on 2024-01-09

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How to Cite

Taques, T. I., Kluthcovcky, A. C. G. C., Martins, C. M., Muller, E. V., Sousa, J. A. V. de, & Borges, P. K. de O. (2024). Factors associated with sepsis and conditions that predict death for elderly people with respiratory diseases. Revista De Enfermagem Da UFSM, 13, e55. https://doi.org/10.5902/2179769285283 (Original work published December 18, 2023)

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