Evaluation of the antifungal potential of Moringa oleifera against yeasts of the genus Candida - integrative literature review
DOI:
https://doi.org/10.5902/2236583466565Keywords:
Moringa oleifera, Candida, Antifungal Agents, PhytotherapyAbstract
It is estimated that 25% of medicines are derived from medicinal plants. Moringa oleifera is a tree belonging to the Moringaceae family widely used in the treatment of diseases, due to its antibacterial, anti-inflammatory and antioxidant properties, among other qualities. The genus Candida represents the main group of yeasts that cause human infections. The use of available antifungals against candidiasis can lead to the development of resistant strains, thus compromising treatment. The aim of this study was to analyze scientific evidence, through an integrative literature review, about the antifungal potential of Moringa oleifera against yeasts of the genus Candida. A bibliographic survey was carried out in the databases: Scientific Electronic Library Online (SciELO), PubMed and Virtual Health Library (BVS / Bireme), using the following descriptors: “Moringa oleifera”, “Candida”, “antifungics” and “Antifungal agents”, with the original and complete articles published in the last 10 years as an eligibility criterion, without language specification and that responded to the research objective. Of the 67 articles found, nine were selected. All the studies analyzed showed that extracts from different parts of M. oleifera have antifungal activity against Candida spp., As well as against other species of pathogens also tested, in addition to their demonstrated low toxicity. Thus, the antimicrobial activity of M. oleiferais highlighted, which places it as a promising source of products to combat fungal infections.
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Mussi-dias V, Araújo, ACO, Silveira, SF, Rocabado, JMA, Araújo, KL. Fungos endofíticos associados a plantas medicinais. Rev Bras Plantas Med. 2012;14(2):261-266.
Badke MR, Budó MLD, Alvim NAT, Zanetti GD, Heisler EV. Saberes e práticas populares de cuidado em saúde com o uso de plantas medicinais. Texto contexto - enferm. 2012; 21(2)363-370.
Rocha MFG, Aguiar FL, Brilhante RS, Cordeiro RA, Teixeira CE, Castelo-Branco DS, et al. Extratos de Moringa oleifera e Vernonia sp. sobre Candida albicans e Microsporum canis isolados de cães e gatos e análise da toxicidade em Artemia sp. Cienc Rural. 2011;41(10):1807-1812.
Ministério da Saúde (BRASIL). Secretaria de Atenção à Saúde. Departamento de Atenção Básica. Práticas integrativas e complementares: plantas medicinais e fitoterapia na Atenção Básica. Brasília: Ministério da Saúde, 2012. Disponível em: https://bvsms.saude.gov.br/bvs/publicacoes/praticas_integrativas_complementares_plantas_medicinais_cab31.pdf. Acesso em: 9 jan. 2023.
Rosa C, Câmara SG, Béria JU. Representações e intenção de uso da fitoterapia na atenção básica à saúde. Ciênc Saúde Coletiva. 2011;16(1):311-318.
Souza CMP, Brandão DO, Silva MSP, Palmeira AC, Simões MOS, Medeiros ACD. Utilização de plantas medicinais com atividade antimicrobiana por usuários do serviço público de saúde em Campina Grande – Paraíba. Rev Bras Pl Med. 2013;15(2)188-193.
Leone A, Spada A, Battezzati A, Schiraldi A, Aristil J, Bertoli S. Cultivation, genetic, ethnopharmacology, phytochemistry and pharmacology of Moringa oleifera leaves: an overview. Int J Mol Sci. 2015; 16(6):12791-12835.
Das PE, Majdalawieh AF, Abu-Yousef IA, Narasimhan S, Poltronieri P. Use of a hydroalcoholic extract of Moringa oleifera leaves for the green synthesis of bismuth nanoparticles and evaluation of their anti-microbial and antioxidant activities. Materials. 2020;13(4):876.
Ferreira PMP, Farias DF, Oliveira JTA, Carvalho AFU. Moringa oleifera: compostos bioativos e potencial nutricional. Rev Nutr. 2008;21(4):431-437.
Farooq F, Rai M, Tiwari A, Khan AA, Farooq S. Medicinal properties of Moringa oleifera: an overview of promising healer. J Med Plants Res. 2012;6(27):4368-4374.
Barbedo LS, Sgarbi DB. Candidíase. DST - J Bras Doenças Sex Transm. 2010;22(1):22-38.
Vieira AJH, Santos JI. Mecanismos de resistência de Candida albicans aos antifúngicos anfotericina B, fluconazol e caspofungina. RBAC. 2017;49(3):235-239.
Neto JX, Pereira ML, Oliveira JT, Rocha-Bezerra LC, Lopes TD, Costa HP, et al. A chitin-binding protein purified from Moringa oleifera seeds presents anticandidal activity by increasing cell membrane permeability and reactive oxygen species production. Front Microbiol. 20178:980.
Rocha MFG, Alencar LP, Brilhante RSN, Sales JA, Ponte YB, Rodrigues PHA, et al. Moringa oleifera inhibits growth of Candida spp. and Hortaeawerneckii isolated from Macrobrachiumamazonicum prawn farming with a wide margin of safety. Cienc Rural. 2014;44(12): 2197-2203.
Das PE, Abu-Yousef IA, Majdalawieh AF, Narasimhan S, Poltronieri P. Green synthesis of encapsulated copper nanoparticles using a hydroalcoholi cextract of Moringa oleifera leaves and assessment of their antioxidant and antimicrobial activities. Molecules. 2020;25(3):555.
Neto JXS, Costa HPS, Vasconcelos IM, Pereira ML, Oliveira JTA, Lopes TDP, et al. Role of membrane sterol and redox system in the anti-Candida activity reported for Mo-CBP 2, a protein from Moringa oleifera seeds. Int J Bio lMacromol. 2020;143:814824.
Onsare JG, Arora DS. Antibiofilm potential of flavonoids extracted from Moringa oleifera seed coat against Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans. J Appl Microbiol. 2014;118(2):313-325.
Goldenstein HG. Efeito antifúngico de extrato de Psidium guajava sobre Candida albicans por formas vegetativas e biofilme [dissertação]. São José dos Campos: Universidade Estadual Paulista, Instituto de Ciência e Tecnologia, 2018.
Kalaiselvi V, Mathammal R, Vijayakumar S, Vaseeharan B. Microwave assisted green synthesis of Hydroxyapatite nanorods using Moringa oleifera flower extract and its antimicrobial applications. Int J Vet Sci Med. 2018;6(2):286-295.
Anand K, Tiloke C, Phulukdaree A, Ranjan B, Chuturgoon A, Singh S, et al. Biosynthesis of palladium nanoparticles by using Moringa oleifera flower extract and their catalytic and biological propertie. J Photochem Photobiol B. 2016;165:87-95.
Abid M, Chohan S, Mehmood MA, Naz S, Naqvi SA. Antifungal potential of indigenous medicinal plants against Myrothecium leaf spot of bitter gourd (Momordica charantia L.). Braz Arch Biol Technol. 2017;60:e17160395.
Ahmadu T, Ahmad K, Ismail SI, Rashed O, Asib N, Omar D. Antifungal efficacy of Moringaoleifera leaf and seed extracts against Botrytis cinerea causing gray mold disease of tomato (Solanum lycopersicum L.). Braz J Biol. 2020;81(4):1007-1022.
Mosquera WG, Servant LY, Guerra BE. Actividad antimicrobiana de hongos endófitos de las plantas medicinales Mammea americana (Calophyllaceae) e Moringa oleifera (Moringaceae). Biomédica. 2020;40(1):55-71.
Önalan Ş, Çevik M. Investigation of the effects of some phytochemicals on Yersinia ruckeri and antimicrobial resistance. Braz J Biol. 2020;80(4):934-942.
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